Výsledky vyhledávání - "Wesley Dopson"

Human-relevant near-organ neuromodulation of the immune system via the splenic nerve

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Bioelectronic modulation of the autonomic nervous system innervating the spleen represents a new therapeutic avenue. Studies in rodents suffer from the limitation that stimulation parameters and anatomy are not directly applicable to hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92afe3a903ca297969decc28e39991e2
http://europepmc.org/articles/PMC8157920

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Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves

Publikováno v: Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Communications Biology
Communications Biology, 3 (1)

Neuromodulation is a new therapeutic pathway to treat inflammatory conditions by modulating the electrical signalling pattern of the autonomic connections to the spleen. However, targeting this sub-division of the nervous system presents specific cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801db54c1f66fd853795a59ed59f7f60

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Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes

Autor: Sonal Patel, Matteo Donegà, Victor Pikov, Bernardete F. Melo, Bradley J. Holinski, Joana F. Sacramento, Daniel J. Chew, Silvia V. Conde, Jesus Prieto-Lloret, Wesley Dopson, Alison Robinson, Nishan Ramnarain, Maria P. Guarino, Kristoffer Famm

Publikováno v: Diabetologia
Digital.CSIC. Repositorio Institucional del CSIC
instname

[Aims/hypothesis] A new class of treatments termed bioelectronic medicines are now emerging that aim to target individual nerve fibres or specific brain circuits in pathological conditions to repair lost function and reinstate a healthy balance. Caro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df02f8585bc4525c4184b5e740898ef0
https://doi.org/10.1007/s00125-017-4533-7

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Quantitative bioanalysis of paracetamol in rats using volumetric absorptive microsampling (VAMS)

Autor: Wesley Dopson, Simon Parry, Philip Denniff, Neil Spooner

Publikováno v: Journal of pharmaceutical and biomedical analysis. 108

Volumetric absorptive microsampling (VAMS) is a simple intuitive technique for collecting and quantitative analysis of dried blood samples. It enables the collection of an accurate blood volume (approximately 10μL) regardless of blood hematocrit. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb32ce1de721649ad8b19a8e1fe131a7
https://pubmed.ncbi.nlm.nih.gov/25710904

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Investigations into the environmental conditions experienced during ambient sample transport: impact to dried blood spot sample shipments

Autor: Chester L. Bowen, Rakesh Lad, Daniel C. Kemp, Carol R Overvold, Mark Lewis, Wesley Dopson

Publikováno v: Bioanalysis. 3(14)

Background: Prior to bioanalysis, sample transport and storage are critical considerations in any pharmacokinetic or toxicokinetic study design. Care must be taken to ensure the shipment is properly packaged and tracked to make certain it arrives at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b4c34883386f5970567c522fb78cae
https://pubmed.ncbi.nlm.nih.gov/21756095

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Determination of drug concentrations using dried blood spots: investigation of blood sampling and collection techniques in Crl:CD(SD) rats

Autor: Matthew Barfield, Cerys A. Lovatt, Sonya D Gade, Alan H. Stokes, Neil Spooner, Simon Parry, David H. Melich, Wesley Dopson, Tammy A Moose, Carol R Overvold

Publikováno v: Laboratory animals. 45(2)

Dried bloodspot (DBS) technology has been available for many decades but only in the last five years has it been considered for routine bioanalysis of blood samples collected on preclinical and clinical studies as part of a drug development programme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b72aae946e88e2738a354fa51f5b025
https://pubmed.ncbi.nlm.nih.gov/21444352

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