Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Autor: Hugh Rosen, Evan T. Powers, Steven J. Brown, Ryan J Paxman, Peter Walter, Lars Plate, John J. Chen, Ciara M Gallagher, Franck Madoux, Wesley Dobbs, Louis Scampavia, Christina B. Cooley, Joseph C. Genereux, Jeffery W. Kelly, R. Luke Wiseman, Timothy P. Spicer, Peter Hodder, Dan Garza

Publikováno v: eLife, Vol 5 (2016)
eLife, vol 5, iss 2016JULY
Plate, L; Cooley, CB; Chen, JJ; Paxman, RJ; Gallagher, CM; Madoux, F; et al.(2016). Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. eLife, 5(2016JULY). doi: 10.7554/eLife.15550. UC Riverside: Retrieved from: http://www.escholarship.org/uc/item/6dt069qj
eLife

Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42133e79e8a3f18ac8f641a246df7f8
https://elifesciences.org/articles/15550

Identifying small molecule regulators of the Proteostasis Network that enhance CFTR protein function

Autor: Dan Garza, William E. Balch, Shilpi Khanna, Matthew Cullen, Kenneth A. Giuliano, Yitan Zhu, Shinichiro Wachi, Peter H. Reinhart, Hui Ge, Jennifer Andersen, Wesley Dobbs, Lawrence Drew, John P. Miller, Bradley D. Tait, Darren M. Hutt

Publikováno v: The FASEB Journal. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bb3b6accb8bd48c513543ef972a5a6f
https://doi.org/10.1096/fasebj.27.1_supplement.lb125