Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Autor: Lars Plate, Christina B Cooley, John J Chen, Ryan J Paxman, Ciara M Gallagher, Franck Madoux, Joseph C Genereux, Wesley Dobbs, Dan Garza, Timothy P Spicer, Louis Scampavia, Steven J Brown, Hugh Rosen, Evan T Powers, Peter Walter, Peter Hodder, R Luke Wiseman, Jeffery W Kelly

Publikováno v: eLife, Vol 5 (2016)

Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genet

Externí odkaz: https://doaj.org/article/42f2f67790644b3da9a9b3bdc96ee5c4

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Autor: Hugh Rosen, Evan T. Powers, Steven J. Brown, Ryan J Paxman, Peter Walter, Lars Plate, John J. Chen, Ciara M Gallagher, Franck Madoux, Wesley Dobbs, Louis Scampavia, Christina B. Cooley, Joseph C. Genereux, Jeffery W. Kelly, R. Luke Wiseman, Timothy P. Spicer, Peter Hodder, Dan Garza

Publikováno v: eLife, Vol 5 (2016)
eLife, vol 5, iss 2016JULY
Plate, L; Cooley, CB; Chen, JJ; Paxman, RJ; Gallagher, CM; Madoux, F; et al.(2016). Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. eLife, 5(2016JULY). doi: 10.7554/eLife.15550. UC Riverside: Retrieved from: http://www.escholarship.org/uc/item/6dt069qj
eLife

Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42133e79e8a3f18ac8f641a246df7f8
https://elifesciences.org/articles/15550

Identifying small molecule regulators of the Proteostasis Network that enhance CFTR protein function

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Publikováno v: The FASEB Journal. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bb3b6accb8bd48c513543ef972a5a6f
https://doi.org/10.1096/fasebj.27.1_supplement.lb125

FEDERAL REGISTER.

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