Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Wesley D. Block"'
1
The DNA-Dependent Protein Kinase Catalytic Subunit Is Phosphorylated In Vivo on Threonine 3950, a Highly Conserved Amino Acid in the Protein Kinase Domain
Autor: Pauline Douglas, Ruiqiong Ye, Wesley D. Block, Katheryn Meek, Shikha Gupta, Xiaoping Cui, Yaping Yu, Susan P. Lees-Miller, Qi Ding, Nick Morrice
Publikováno v: Molecular and Cellular Biology. 27:1581-1591
The protein kinase activity of the DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA double-strand breaks (DSBs) via the process of nonhomologous end joining (NHEJ). However, to date, the only target shown to be functionally rel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47f8993c7283b92660929f24b3231e6
https://doi.org/10.1128/mcb.01962-06
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2
Analysis of DNA-Dependent Protein Kinase-Mediated DNA End Joining by Two-Photon Fluorescence Cross-Correlation Spectroscopy
Autor: Wesley D. Block, David T. Cramb, Dennis Merkle, Susan P. Lees-Miller, Yaping Yu
Publikováno v: Biochemistry. 45:4164-4172
Nonhomologous end joining (NHEJ) is the primary mechanism by which mammalian cells repair DNA double-strand breaks (DSBs). Proteins known to play a role in NHEJ include the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the Ku 70/Ku 80 he
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda9db710907dca5d999d2b781c64ab8
https://doi.org/10.1021/bi0524060
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3
Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends
Autor: Qi Ding, Wesley D. Block, Katheryn Meek, Dennis Merkle, Yaping Yu, Susan P. Lees-Miller, Jessica L. Gifford
Publikováno v: Nucleic Acids Research. 32:4351-4357
Non-homologous end joining (NHEJ) is one of the primary pathways for the repair of ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) in mammalian cells. Proteins required for NHEJ include the catalytic subunit of the DNA-dependent prote
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948fe5b7990921f89b71652bf50efbd0
https://doi.org/10.1093/nar/gkh761
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4
Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine
Autor: Susan P. Lees-Miller, Dennis Merkle, Katheryn Meek, Wesley D. Block
Publikováno v: Nucleic Acids Research. 32:1967-1972
Caffeine inhibits cell cycle checkpoints, sensitizes cells to ionizing radiation-induced cell killing and inhibits the protein kinase activity of two cell cycle checkpoint regulators, Ataxia-Telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825414eacc2f0cf5101c5cfd4a2d7ae3
https://doi.org/10.1093/nar/gkh508
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5
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21
Autor: Yaping Yu, Susan P. Lees-Miller, Wesley D. Block
Publikováno v: Nucleic Acids Research. 32:997-1005
Replication protein A (RPA) is a single-stranded DNA (ssDNA) binding protein involved in various processes, including nucleotide excision repair and DNA replication. The 32 kDa subunit of RPA (RPA32) is phosphorylated in response to various DNA-damag
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c281f4020ffc8f7a113bd2dbb50b663b
https://doi.org/10.1093/nar/gkh265
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6
Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine
Autor: Aaron A. Goodarzi, Paul Clarke, Darko Curman, Bruno Cinel, Bin-Bing S. Zhou, David E. Williams, James R. A. Hutchins, Wesley D. Block, Michel Roberge, Raymond J. Andersen, Susan P. Lees-Miller, Natalie T. Rundle
Publikováno v: ResearcherID
Cells can respond to DNA damage by activating checkpoints that delay cell cycle progression and allow time for DNA repair. Chemical inhibitors of the G(2) phase DNA damage checkpoint may be used as tools to understand better how the checkpoint is reg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4fa829094c05550ae58d224bc89838
https://doi.org/10.1074/jbc.m100728200
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7
Purification and Characterization of ATM from Human Placenta
Autor: Pauline Douglas, Ruiqiong Ye, Yoichi Taya, Doug W. Chan, Martin F. Lavin, Wesley D. Block, Marc S. Wold, Jennifer L. Pelley, Aaron A. Goodarzi, Seong-Cheol Son, Kum Kum Khanna, Susan P. Lees-Miller
Publikováno v: Journal of Biological Chemistry. 275:7803-7810
ATM is mutated in the human genetic disorder ataxia telangiectasia, which is characterized by ataxia, immune defects, and cancer predisposition. Cells that lack ATM exhibit delayed up-regulation of p53 in response to ionizing radiation. Serine 15 of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f15a33896791954ecfb089e55998425
https://doi.org/10.1074/jbc.275.11.7803
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10
Sex ratio for medical residencies
Autor: Wesley D. Block
Mark Baerlocher and Allan Detsky report that, between 1995 and 2004, men were more likely than women to be rejected from their top-ranked discipline when applying to Canadian residency programs.[1][1] They suggest that female residency applicants mig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df60ac29da82c6573b65e9b18f78a4cb
https://europepmc.org/articles/PMC1455421/
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