Zobrazeno 1 - 10
of 340
pro vyhledávání: '"Wesley C. Van Voorhis"'
Autor:
Michael K. Fenwick, Phillip G. Pierce, Jan Abendroth, Kayleigh F. Barrett, Lynn K. Barrett, Kalinga Bowatte, Ryan Choi, Ian Chun, Deborah G. Conrady, Justin K. Craig, David M. Dranow, Bradley Hammerson, Tate Higgins, Donald D. Lorimer, Peer Lukat, Stephen J. Mayclin, Stephen Nakazawa Hewitt, Ying Po Peng, Ashwini Shanbhogue, Hayden Smutney, Matthew Z. Z. Stigliano, Logan M. Tillery, Hannah S. Udell, Ellen G. Wallace, Amy E. DeRocher, Isabelle Q. Phan, Bart L. Staker, Sandhya Subramanian, Wesley C. Van Voorhis, Wulf Blankenfeldt, Rolf Müller, Thomas E. Edwards, Peter J. Myler
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Griselimycin, a cyclic depsidecapeptide produced by Streptomyces griseus, is a promising lead inhibitor of the sliding clamp component of bacterial DNA polymerases (β-subunit of Escherichia coli DNA pol III). It was previously shown to inhi
Externí odkaz:
https://doaj.org/article/1a656d43c6764dba945de1b0c7cfbe21
Autor:
Thao T. Truong, Karissa Crawford, Ichih Wang-McGuire, Kendal Jensen, Aisha Mushtaq, Nicole A. P. Lieberman, Frederick S. Buckner, Wesley C. Van Voorhis, Brad T. Cookson, Stephen J. Salipante, Joshua A. Lieberman
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 10 (2024)
ABSTRACT Leishmaniasis is a rare disease in the United States, with an estimated annual incidence of dozens of cases occurring primarily in travelers, migrants, and military personnel. True disease incidence is unknown, since leishmaniasis is not a n
Externí odkaz:
https://doaj.org/article/ea705f21d419493a84fac5e5d369c85f
Autor:
Maria Cristina Ferreira de Sousa, Dennis Imhof, Kai Pascal Alexander Hänggeli, Ryan Choi, Matthew A. Hulverson, Samuel L.M. Arnold, Wesley C. Van Voorhis, Erkang Fan, Sánchez-Sánchez Roberto, Luis M. Ortega-Mora, Andrew Hemphill
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 25, Iss , Pp 100553- (2024)
Toxoplasma gondii and Neospora caninum are major worldwide morbidity-causing pathogens. Bumped kinase inhibitors (BKIs) are a compound class that has been optimized to target the apicomplexan calcium-dependent protein kinase 1 (CDPK1) – and several
Externí odkaz:
https://doaj.org/article/5d45770ad7984b1f80ca4e9a68cdce54
Autor:
Cindy X. Zhang, Thomas M. Conrad, David Hermann, Melita A. Gordon, Eric Houpt, Pui‐Ying Iroh Tam, Khuzwayo C. Jere, Wilfred Nedi, Darwin J. Operario, Jacob Phulusa, Gerald V. Quinnan Jr, Leigh A. Sawyer, Lynn K. Barrett, Herbert Thole, Neema Toto, Wesley C. Van Voorhis, Samuel L. M. Arnold
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 3, Pp 410-423 (2024)
Abstract Oral drug absorption kinetics are usually established in populations with a properly functioning gastrointestinal tract. However, many diseases and therapeutics can alter gastrointestinal physiology and cause diarrhea. The extent of diarrhea
Externí odkaz:
https://doaj.org/article/eb41958c05d84d0fb5af26988b5b95cf
Autor:
Marta Giovanetti, Cynthia Vazquez, Mauricio Lima, Emerson Castro, Analia Rojas, Andrea Gomez de la Fuente, Carolina Aquino, Cesar Cantero, Fatima Fleitas, Juan Torales, Julio Barrios, Maria J. Ortega, Maria L. Gamarra, Shirley Villalba, Tania Alfonzo, Joilson Xavier, Talita Adelino, Hegger Fritsch, Felipe C.M. Iani, Glauco C. Pereira, Carla de Oliveira, Gabriel Schuab, Evandra S. Rodrigues, Simone Kashima, Juliana Leite, Lionel Gresh, Leticia Franco, Houriiyah Tegally, Wesley C. Van Voorhis, Richard Lessels, Ana Maria Bispo de Filippis, Andrea Ojeda, Guillermo Sequera, Romeo Montoya, Edward C. Holmes, Tulio de Oliveira, Jairo M. Rico, José Lourenço, Vagner Fonseca, Luiz C.J. Alcantara
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 9, Pp 1859-1863 (2023)
The spread of Chikungunya virus is a major public health concern in the Americas. There were >120,000 cases and 51 deaths in 2023, of which 46 occurred in Paraguay. Using a suite of genomic, phylodynamic, and epidemiologic techniques, we characterize
Externí odkaz:
https://doaj.org/article/a0c4a9d363694c85a1dd6469d68f9fb0
Autor:
Joilson Xavier, Luiz Carlos Junior Alcantara, Vagner Fonseca, Mauricio Lima, Emerson Castro, Hegger Fritsch, Carla Oliveira, Natalia Guimarães, Talita Adelino, Mariane Evaristo, Evandra S. Rodrigues, Elaine Vieira Santos, Debora de La-Roque, Laise de Moraes, Stephane Tosta, Adelino Neto, Alexander Rosewell, Ana Flavia Mendonça, Anderson Leite, Andreza Vasconcelos, Arabela L. Silva de Mello, Bergson Vasconcelos, Camila A. Montalbano, Camila Zanluca, Carla Freitas, Carlos F. C. de Albuquerque, Claudia Nunes Duarte dos Santos, Cleiton S. Santos, Cliomar Alves dos Santos, Crhistinne C. Maymone Gonçalves, Dalane Teixeira, Daniel F. L. Neto, Diego Cabral, Elaine C. de Oliveira, Ethel L. Noia Maciel, Felicidade Mota Pereira, Felipe Iani, Fernanda P. de Carvalho, Gabriela Andrade, Gabriela Bezerra, Gislene G. de Castro Lichs, Glauco Carvalho Pereira, Haline Barroso, Helena Cristina Ferreira Franz, Hivylla Ferreira, Iago Gomes, Irina N. Riediger, Isabela Rodrigues, Isadora C. de Siqueira, Jacilane Silva, Jairo Mendez Rico, Jaqueline Lima, Jayra Abrantes, Jean Phellipe M. do Nascimento, Judith N. Wasserheit, Julia Pastor, Jurandy J. F. de Magalhães, Kleber Giovanni Luz, Lidio G. Lima Neto, Livia C. V. Frutuoso, Luana Barbosa da Silva, Ludmila Sena, Luis Arthur F. de Sousa, Luiz Augusto Pereira, Luiz Demarchi, Magaly C. B. Câmara, Marcela G. Astete, Maria Almiron, Maricelia Lima, Marina C. S. Umaki Zardin, Mayra M. Presibella, Melissa B. Falcão, Michael Gale, Naishe Freire, Nelson Marques, Noely F. O. de Moura, Pedro E. Almeida Da Silva, Peter Rabinowitz, Rivaldo V. da Cunha, Karen S. Trinta, Rodrigo F. do Carmo Said, Rodrigo Kato, Rodrigo Stabeli, Ronaldo de Jesus, Roselene Hans Santos, Simone Kashima, Svetoslav N. Slavov, Tamires Andrade, Themis Rocha, Thiago Carneiro, Vanessa Nardy, Vinicius da Silva, Walterlene G. Carvalho, Wesley C. Van Voorhis, Wildo N. Araujo, Ana M. B. de Filippis, Marta Giovanetti
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The emergence and reemergence of mosquito-borne diseases in Brazil such as yellow fever, zika, chikungunya, and dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya vir
Externí odkaz:
https://doaj.org/article/fc80f14a3b9f4005a022c95760fd90fe
Publikováno v:
Separations, Vol 11, Iss 7, p 194 (2024)
Fragment-based drug discovery (FBDD) focuses on small compounds, known as fragments, typically with a molecular weight of less than 300 Da. This study highlights the benefits of employing a pure natural product library for FBDD, contrasting with the
Externí odkaz:
https://doaj.org/article/cfdfca4b329547de8140fbd8691fa18b
Autor:
Paul Kelly, William A Petri, Rashidul Haque, Ibrahim A Khalil, Lynn Barrett, Tom Kennedy, Timothy Wells, Christopher D Huston, James Platts-mills, Grace S Yang, Richard Omore, Ian H Gilbert, Sumiti Vinayak, Boris Striepen, Ujjini H Manjunatha, Wesley C Van Voorhis, Samuel L M Arnold, Beatriz Baragana, Frederick S Buckner, Jeremy D Burrows, Maria A Caravedo, Ryan Choi, Robert K M Choy, Eugenio de Hostos, Thierry Diagana, Suzanne Duce, Matthew A Hulverson, Pui-Ying Iroh Tam, Minju Kim, Poonum Korpe, Benoît Laleu, Diana Lalika, Fabrice Laurent, Case W McNamara, Marvin J Meyers, Roberta M O’Connor, Kayode K Ojo, Philipp Olias, Nede Ovbiebo, Mattie C Pawlowic, Gladys Queen, Divya Rao, Kevin Reed, Michael W Riggs, Jennifer L Roxas, Adam Sateriale, Deborah A Schaefer, L David Sibley, Jonathan M Spector, Chris Tonkin, Timilehin E Toye, Saul Tzipori, A Clinton White
Publikováno v:
BMJ Global Health, Vol 8, Iss 8 (2023)
Externí odkaz:
https://doaj.org/article/540e409047fd43baae051b1737c1bbc5
Autor:
Matthew A. Hulverson, Samantha A. Michaels, Jin Woo Lee, Karen L. Wendt, Linh T. Tran, Ryan Choi, Wesley C. Van Voorhis, Robert H. Cichewicz, Kayode K. Ojo
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT There is an unmet need for effective therapies for treating diseases associated with the intestinal parasite Giardia lamblia. In this study, a library of chemically validated purified natural products and fungal extracts was screened for che
Externí odkaz:
https://doaj.org/article/35366aac897e41299edec8dd1d7bd193
Autor:
Amin Addetia, Young-Jun Park, Tyler Starr, Allison J. Greaney, Kaitlin R. Sprouse, John E. Bowen, Sasha W. Tiles, Wesley C. Van Voorhis, Jesse D. Bloom, Davide Corti, Alexandra C. Walls, David Veesler
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112621- (2023)
Summary: Continued evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is eroding antibody responses elicited by prior vaccination and infection. The SARS-CoV-2 receptor-binding domain (RBD) E406W mutation abrogates neutralizati
Externí odkaz:
https://doaj.org/article/958618b6d6dc4a05a3c785030b25accd