Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Wesam S. Qayed"'
1
Akademický článek
Anti-Allergic and Anti-Inflammatory Effects of Lidocaine-Derived Organic Compounds in a House Dust Mite-Induced Allergic Rhinitis Mouse Model
Autor: Seung-Heon Shin, Mi-Kyung Ye, Mi-Hyun Chae, Sang-Yen Geum, Ahmed S. Aboraia, Abu-Baker M. Abdel-Aal, Wesam S. Qayed, Hend A. A. Abd El-wahab, Ola F. Abou-Ghadir, Tarek Aboul-Fadl
Publikováno v: Biomedicines, Vol 12, Iss 9, p 1965 (2024)
Allergic rhinitis (AR) is a common chronic disease that significantly impacts the quality of life. Lidocaine is known to have anti-inflammatory and immunomodulatory effects. This study evaluated the effect of lidocaine analogs in a Dermatophagoides p
Externí odkaz: https://doaj.org/article/319cde51cccb4f95a3fc635dada48287
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2
Akademický článek
Effects of Lidocaine-Derived Organic Compounds on Eosinophil Activation and Survival
Autor: Seung-Heon Shin, Mi-Kyung Ye, Mi-Hyun Chae, Sang-Yen Geum, Ahmed S. Aboraia, Abu-Baker M. Abdel-Aal, Wesam S. Qayed, Hend A. A. Abd El-wahab, Ola F. Abou-Ghadir, Tarek Aboul-Fadl
Publikováno v: Molecules, Vol 28, Iss 15, p 5696 (2023)
Lidocaine, a local anesthetic, is known to possess anti-inflammatory properties. However, its clinical use is limited by inconveniences, such as its local synesthetic effects. This study evaluated lidocaine analogs designed and synthesized to overcom
Externí odkaz: https://doaj.org/article/9d319026c3ce4b48a6abe5567c0493ce
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3
Akademický článek
In Silico Study towards Repositioning of FDA-Approved Drug Candidates for Anticoronaviral Therapy: Molecular Docking, Molecular Dynamics and Binding Free Energy Calculations
Autor: Wesam S. Qayed, Rafaela S. Ferreira, José Rogério A. Silva
Publikováno v: Molecules, Vol 27, Iss 18, p 5988 (2022)
The SARS-CoV-2 targets were evaluated for a set of FDA-approved drugs using a combination of drug repositioning and rigorous computational modeling methodologies such as molecular docking and molecular dynamics (MD) simulations followed by binding fr
Externí odkaz: https://doaj.org/article/86cba2efb441442292fcee96ed20b2b0
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5
Synthesis, biological evaluation, and molecular modeling studies of acetophenones‐tethered 1,2,4‐triazoles and their oximes as epidermal growth factor receptor inhibitors
Autor: Hamdy M. Abdel-Rahman, Wesam S. Qayed, Hend A. A. Abd El-wahab, Ahmed Ali
Publikováno v: Chemical Biology & Drug Design. 100:981-993
A series of 5-(4-pyridyl)-1,2,4-triazoles hybrids with acetophenones and their oxime derivatives was rationally designed and synthesized as epidermal growth factor receptor (EGFR) kinase inhibitors. Initially, drug Likeness and pharmacokinetics prope
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e888087c6d2077d032e0a446d38bb6
https://doi.org/10.1111/cbdd.13982
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6
Computational Analysis of SAM Analogs as Methyltransferase Inhibitors of nsp16/nsp10 Complex from SARS-CoV-2
Autor: Alessandra M. Balieiro, Eduarda L. S. Anunciação, Clauber H. S. Costa, Wesam S. Qayed, José Rogério A. Silva
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 13972
Methyltransferases (MTases) enzymes, responsible for RNA capping into severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are emerging important targets for the design of new anti-SARS-CoV-2 agents. Here, analogs of S-adenosylmethionine (SA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6635e4364b47527de9c17d7265481d36
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8
Ionic liquid of ketoprofen-piperine modulates the pharmaceutical and therapeutic characters of ketoprofen
Autor: Sara A. Hassan, Sheryhan F. Gad, Hajjaj H.M. Abdu-Allah, Wesam S. Qayed, Sara A. AbouElmagd, Elsayed A. Ibrahim
Publikováno v: International journal of pharmaceutics. 620
Efficiency of drug delivery is product of drug properties and formulation design. Modulating drug's unfavorable properties such as poor solubility or permeation is the first step towards optimum delivery. By combining a drug with a selected bulky cou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f2d0e7beb67504ce30c129f0a6ee18
https://pubmed.ncbi.nlm.nih.gov/35405279
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9
Phytochemical investigation, molecular docking studies and DFT calculations on the antidiabetic and cytotoxic activities of Gmelina philippensis CHAM
Autor: Hanaa M. Sayed, Amany S. Ahmed, Iman SA. Khallaf, Wesam S. Qayed, Anber F. Mohammed, Hanan S.M. Farghaly, Ayman Asem
Publikováno v: Journal of Ethnopharmacology. 303:115938
Gmelina philippensis CHAM is an ornamental plant that is distributed in South Asia and warm regions of the Mediterranean area. The plant is traditionally applied in folk medicine for the treatment of diabetes.To evaluate the cytotoxic and the antidia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a58b19eabee0b75e16729d47daef45
https://doi.org/10.1016/j.jep.2022.115938
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10
Novel Azine Linked Hybrids of 2-Indolinone and Thiazolodinone Scaffolds as CDK2 Inhibitors with Potential Anticancer Activity: In Silico Design, Synthesis, Biological, Molecular Dynamics and Binding Free Energy Studies
Autor: Wesam S, Qayed, Mostafa A, Hassan, Wael M, El-Sayed, José, Rogério A Silva, Tarek, Aboul-Fadl
Publikováno v: Bioorganic Chemistry. 126:105884
Molecular hybrid of 2-indolinone-thiazolidinone is a well known scaffold for variable biological activities including anticancer activity. Accordingly, in the current work aided with structure-based molecular modeling studies, a library of novel twen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80557b159e2a250513ece5387185371f
https://doi.org/10.1016/j.bioorg.2022.105884
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