Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Wesam Bassiouni"'
Autor:
Pavel Zhabyeyev, Brent McLean, Wesam Bassiouni, Robert Valencia, Manish Paul, Ahmed M. Darwesh, John M. Seubert, Saugata Hazra, Gavin Y. Oudit
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 12 (2023)
Background Identifying new therapeutic targets for preventing the myocardial ischemia–reperfusion injury would have profound implications in cardiovascular medicine. Myocardial ischemia–reperfusion injury remains a major clinical burden in patien
Externí odkaz:
https://doaj.org/article/ed1d9a0d30f24e35aea95c55043ad235
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 111, Iss , Pp 1458-1466 (2019)
Introduction: Prostaglandins (PGs) play an important role in corpus cavernosum relaxation, as evidenced by alprostadil being used as a drug for erectile dysfunction. Reports about the effect of cyclooxygenase (COX) inhibitors on erectile function are
Externí odkaz:
https://doaj.org/article/bca7452a5115458398b5881b9d17ab78
Autor:
Ahmed M. Darwesh, Wesam Bassiouni, Adeniyi Michael Adebesin, Abdul Sattar Mohammad, John R. Falck, John M. Seubert
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5261 (2020)
While survival rates have markedly improved following cardiac ischemia-reperfusion (IR) injury, the resulting heart damage remains an important issue. Preserving mitochondrial quality and limiting NLRP3 inflammasome activation is an approach to limit
Externí odkaz:
https://doaj.org/article/68560ac239494f96a949d71b25dc1cdc
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:46-47
Publikováno v:
Expert opinion on drug metabolismtoxicology. 18(7-8)
Cytochrome P450s (CYPs) are a superfamily of monooxygenases with diverse biological roles. CYP2J2 is an isozyme highly expressed in the heart where it metabolizes endogenous substrates such as N-3/N-6 polyunsaturated fatty acids (PUFA) to produce lip
Publikováno v:
The FASEB Journal. 36
Publikováno v:
The FEBS Journal. 288:7162-7182
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that were first discovered as proteases, which target and cleave extracellular proteins. During the past 20 years, however, intracellular roles of MMPs were uncovered and research on
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:132
Publikováno v:
Canadian journal of physiology and pharmacology. 100(2)
Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein which mediates staurosporine (STS) – induced cell death. AIF cleavage and translocation to the cytosol is thought to be calpain-1-dependent as calpain inhibitors reduce AIF proteolysis
Publikováno v:
Pharmacological Reports
Pharmacological Reports, Inst. of Pharmacology, Polish Acad. of Sciences, 2019, 71, pp.659-668. ⟨10.1016/j.pharep.2019.03.004⟩
Pharmacological Reports, Inst. of Pharmacology, Polish Acad. of Sciences, 2019, 71, pp.659-668. ⟨10.1016/j.pharep.2019.03.004⟩
Sildenafil (PDE5-inhibitor) and alprostadil (PGE1) are used in combination clinically for the management of some cases of erectile dysfunction. Despite the roles of prostaglandins (PG) and nitric oxide (NO) pathways in contractility of bladder smooth