Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Wes Sanders"'
Autor:
Laura I. Levi, Emily A. Madden, Jeremy Boussier, Diana Erazo, Wes Sanders, Thomas Vallet, Veronika Bernhauerova, Nathaniel J. Moorman, Mark T. Heise, Marco Vignuzzi
Publikováno v:
Microorganisms, Vol 12, Iss 9, p 1794 (2024)
Chikungunya virus (CHIKV) is a mosquito-borne RNA virus that poses an emerging threat to humans. In a manner similar to other RNA viruses, CHIKV encodes an error-prone RNA polymerase which, in addition to producing full-length genomes, gives rise to
Externí odkaz:
https://doaj.org/article/00b34d58734a413eb02922eff3e1bfa2
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Human cytomegalovirus (HCMV) requires the robust expression of two immediate early proteins, IE1 and IE2, immediately upon infection to suppress the antiviral response and promote viral gene expression. While transcriptional control of IE1 a
Externí odkaz:
https://doaj.org/article/ccc81b91099b47a2a54e9e2ae7a19fed
Autor:
Stephanie E. Ander, Kathryn S. Carpentier, Wes Sanders, Cormac J. Lucas, Austin J. Jolly, Cydney N. Johnson, David W. Hawman, Mark T. Heise, Nathaniel J. Moorman, Thomas E. Morrison
Publikováno v:
Viruses, Vol 16, Iss 6, p 861 (2024)
We previously reported that deletion of a 44-nucleotide element in the 3′ untranslated region (UTR) of the Chikungunya virus (CHIKV) genome enhances the virulence of CHIKV infection in mice. Here, we find that while this 44-nucleotide deletion enha
Externí odkaz:
https://doaj.org/article/de9d1c236b594b4e9eb72f3e4301308c
Autor:
Jennifer Diaz, John Sears, Che-Kang Chang, Jane Burdick, Isabella Law, Wes Sanders, Colton Linnertz, Paul Sylvester, Nathaniel Moorman, Martin T. Ferris, Mark T. Heise
Publikováno v:
Viruses, Vol 16, Iss 4, p 636 (2024)
RNA viruses quickly evolve subtle genotypic changes that can have major impacts on viral fitness and host range, with potential consequences for human health. It is therefore important to understand the evolutionary fitness of novel viral variants re
Externí odkaz:
https://doaj.org/article/afcc2e359b2944a89cbb7635dfd9a8a0
Autor:
Ethan J. Fritch, Wes Sanders, Amy C. Sims, Laura E. Herring, Natalie K. Barker, Athena A. Schepmoes, Karl K. Weitz, Jordan R. Texier, Dirk P. Dittmer, Lee M. Graves, Richard D. Smith, Katrina M. Waters, Nathaniel J. Moorman, Ralph S. Baric, Rachel L. Graham
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106780- (2023)
Summary: Among all RNA viruses, coronavirus RNA transcription is the most complex and involves a process termed “discontinuous transcription” that results in the production of a set of 3′-nested, co-terminal genomic and subgenomic RNAs during i
Externí odkaz:
https://doaj.org/article/2bc0d11dd93b4dea94883e22e03d5645
Autor:
Jennifer E. Jones, Kristin M. Long, Alan C. Whitmore, Wes Sanders, Lance R. Thurlow, Julia A. Brown, Clayton R. Morrison, Heather Vincent, Kayla M. Peck, Christian Browning, Nathaniel Moorman, Jean K. Lim, Mark T. Heise
Publikováno v:
mBio, Vol 8, Iss 6 (2017)
ABSTRACT Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade. These include a recent outbreak in the Caribbean islands
Externí odkaz:
https://doaj.org/article/8f27fe69f5174573bc32b852d1bbb70e
Autor:
Nathaniel J. Moorman, Nikhil Madadi, Daniel N. Streblow, Nicole N. Haese, Robert Bostwick, Mark T. Heise, Wes Sanders, Theresa H Nguyen, Corinne E. Augelli-Szafran, Nichole A Towers, Omar Moukha-Chafiq, Victor R. DeFilippis, Joseph A. Maddry, Sixue Zhang, Ashish K. Pathak, Mark J. Suto, Subramaniam Ananthan, Sharon Taft-Benz, Lynn Rasmussen, Shuklendu D Karyakarte, Michael Denton, Nicholas A May, Kevin J Rodzinak, Aaron D Streblow, Thomas E. Morrison
Publikováno v:
Antimicrob Agents Chemother
Venezuelan equine encephalitis virus (VEEV) is a reemerging alphavirus that can cause encephalitis resulting in severe human morbidity and mortality. Using a high-throughput cell-based screen, we identified a quinolinone compound that protected again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19d1e226b321e833dfc136126ea7547
https://pubmed.ncbi.nlm.nih.gov/34152810
https://pubmed.ncbi.nlm.nih.gov/34152810
Publikováno v:
Journal of Virology
RNA sequencing (RNA-seq) is an important tool for studying RNA transcripts, particularly during active viral infection. We made use of RNA-seq to study human herpesvirus 6B (HHV-6B) infection.
The “omics” revolution of recent years has simpl
The “omics” revolution of recent years has simpl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bb79ced7c0055a52507c2054f551ec
https://pubmed.ncbi.nlm.nih.gov/33627386
https://pubmed.ncbi.nlm.nih.gov/33627386
Autor:
Heather A. Vincent, Kristin M. Long, Mark T. Heise, Clayton R. Morrison, Wes Sanders, Sanjay Sarkar, Marta C Cruz Cisneros, Kenneth S. Plante, Emily A Madden, Grace Reynolds, Nathanial J Moorman, Sharon Taft-Benz, Ashlyn Morgan White, Katrina M. Kutchko, Alain Laederach
Publikováno v:
J Virol
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus associated with debilitating arthralgia in humans. RNA secondary structure in the viral genome plays an important role in the lifecycle of alphaviruses; however, the specific role of RNA struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8e09937ddfe7d7bbcbe162d460cccd
https://europepmc.org/articles/PMC7925192/
https://europepmc.org/articles/PMC7925192/
Autor:
Heather A. Vincent, Emily A Madden, Mark T. Heise, Nathaniel J. Moorman, Rachel L. Graham, Ethan J. Fritch, Ralph S. Baric, Wes Sanders
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Coronaviruses, including SARS-CoV-2 the etiological agent of COVID-19 disease, have caused multiple epidemic and pandemic outbreaks in the past 20 years1–3. With no vaccines, and only recently developed antiviral therapeutics, we are ill equipped t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4c3d19810d5fb15a04b7f5d2090731
http://europepmc.org/articles/PMC7310623
http://europepmc.org/articles/PMC7310623