Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19.

Autor: Khanna K; Cardiovascular Research Institute, University of California, San Francisco, California., Raymond WW; Cardiovascular Research Institute, University of California, San Francisco, California., Jin J; Vitalant Research Institute, San Francisco, California., Charbit AR; Cardiovascular Research Institute, University of California, San Francisco, California., Gitlin I; Cardiovascular Research Institute, University of California, San Francisco, California., Tang M; Division of Pulmonary, Critical Care, Allergy and Sleep and the Department of Medicine, University of California, San Francisco, California., Werts AD; Lovelace Biomedical Research Institute, Albuquerque, New Mexico., Barrett EG; Lovelace Biomedical Research Institute, Albuquerque, New Mexico., Cox JM; Lovelace Biomedical Research Institute, Albuquerque, New Mexico., Birch SM; Lovelace Biomedical Research Institute, Albuquerque, New Mexico., Martinelli R; Vitalant Research Institute, San Francisco, California., Sperber HS; Vitalant Research Institute, San Francisco, California., Franz S; Vitalant Research Institute, San Francisco, California., Duff T; Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Dublin, Ireland., Hoffmann M; Infection Biology Unit, German Primate Center, Göttingen, Germany.; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany., Healy AM; School of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College Dublin, Dublin, Ireland.; Synthesis and Solid State Pharmaceutical Cluster (SSPC), The Science Foundation Ireland Research Centre for Pharmaceuticals, Trinity College Dublin, Dublin, Ireland., Oscarson S; Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Dublin, Ireland., Pöhlmann S; Infection Biology Unit, German Primate Center, Göttingen, Germany.; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany., Pillai SK; Vitalant Research Institute, San Francisco, California.; Department of Laboratory Medicine, University of California, San Francisco, California., Simmons G; Vitalant Research Institute, San Francisco, California.; Department of Laboratory Medicine, University of California, San Francisco, California., Fahy JV; Cardiovascular Research Institute, University of California, San Francisco, California.; Division of Pulmonary, Critical Care, Allergy and Sleep and the Department of Medicine, University of California, San Francisco, California.

Publikováno v: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2022 Sep 01; Vol. 323 (3), pp. L372-L389. Date of Electronic Publication: 2022 Jun 28.

Oral Vaccination Protects Against Severe Acute Respiratory Syndrome Coronavirus 2 in a Syrian Hamster Challenge Model.

Autor: Johnson S; Vaxart, South San Francisco, California, USA., Martinez CI; Vaxart, South San Francisco, California, USA., Tedjakusuma SN; Vaxart, South San Francisco, California, USA., Peinovich N; Vaxart, South San Francisco, California, USA., Dora EG; Vaxart, South San Francisco, California, USA., Birch SM; Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA., Kajon AE; Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA., Werts AD; Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA., Tucker SN; Vaxart, South San Francisco, California, USA.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2022 Jan 05; Vol. 225 (1), pp. 34-41.

The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling.

Autor: Sodhi CP; Division of General Pediatric Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA.; Department of Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA., Wipf P; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA., Yamaguchi Y; Division of General Pediatric Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA.; Department of Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA., Fulton WB; Division of General Pediatric Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA.; Department of Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA., Kovler M; Division of General Pediatric Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA.; Department of Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA., Niño DF; Division of General Pediatric Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA.; Department of Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA., Zhou Q; Division of General Pediatric Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA.; Department of Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA., Banfield E; Division of General Pediatric Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA., Werts AD; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA., Ladd MR; Division of General Pediatric Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA.; Department of Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA., Buck RH; Abbott Nutrition, a Division of Abbott Laboratories, Columbus, OH, USA., Goehring KC; Abbott Nutrition, a Division of Abbott Laboratories, Columbus, OH, USA., Prindle T Jr; Division of General Pediatric Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA.; Department of Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA., Wang S; Division of General Pediatric Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA.; Department of Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA., Jia H; Division of General Pediatric Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA.; Department of Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA., Lu P; Division of General Pediatric Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA.; Department of Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA., Hackam DJ; Division of General Pediatric Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA. dhackam1@jhmi.edu.; Department of Surgery, Johns Hopkins University and Johns Hopkins Children's Center, Baltimore, MD, 21287, USA. dhackam1@jhmi.edu.

Publikováno v: Pediatric research [Pediatr Res] 2021 Jan; Vol. 89 (1), pp. 91-101. Date of Electronic Publication: 2020 Mar 27.

A Novel Role for Necroptosis in the Pathogenesis of Necrotizing Enterocolitis.

Autor: Werts AD; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Fulton WB; Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Ladd MR; Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Saad-Eldin A; Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Chen YX; Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Kovler ML; Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Jia H; Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Banfield EC; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Buck RH; Abbott Nutrition, Columbus, Ohio., Goehring K; Abbott Nutrition, Columbus, Ohio., Prindle T Jr; Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Wang S; Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Zhou Q; Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Lu P; Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Yamaguchi Y; Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Sodhi CP; Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: csodhi@jhmi.edu., Hackam DJ; Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: Dhackam1@jhmi.edu.

Publikováno v: Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2020; Vol. 9 (3), pp. 403-423. Date of Electronic Publication: 2019 Nov 19.

Development of Intestinal Scaffolds that Mimic Native Mammalian Intestinal Tissue.

Autor: Ladd MR; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland., Costello CM; Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York., Gosztyla C; Department of Surgery, Walter Reed National Military Medical Center, Bethesda, Maryland., Werts AD; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland., Johnson B; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland., Fulton WB; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland., Martin LY; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland., Redfield EJ; Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York., Crawford B; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland., Panaparambil R; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland., Sodhi CP; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland., March JC; Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York., Hackam DJ; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.

Publikováno v: Tissue engineering. Part A [Tissue Eng Part A] 2019 Sep; Vol. 25 (17-18), pp. 1225-1241. Date of Electronic Publication: 2019 Sep 03.