Safety, tolerability, pharmacokinetics and pharmacokinetic-pharmacodynamic modelling of the novel H 4 receptor inhibitor SENS-111 using a modified caloric test in healthy subjects

Autor: Venail, Frederic, Attali, Pierre, Wersinger, Eric, Gomeni, Roberto, Poli, Sonia, Schmerber, Sébastien

Publikováno v: British Journal of Clinical Pharmacology
British Journal of Clinical Pharmacology, Wiley, 2018, 84 (12), pp.2836-2848. ⟨10.1111/bcp.13744⟩

International audience; AIM:A Phase 1 study was performed to evaluate safety, pharmacokinetics (PK) and pharmacodynamics (PD) of the selective histamine H4 receptor antagonist SENS-111, an oral small molecule.METHODS:One hundred healthy subjects were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bdd591c90f681d1262acebbfdc315a17
https://hal.umontpellier.fr/hal-02315424

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Effect of the novel histamine H4 receptor antagonist SENS-111 on spontaneous nystagmus in a rat model of acute unilateral vestibular loss.

Autor: Petremann, Mathieu, Gueguen, Cindy, Delgado Betancourt, Viviana, Wersinger, Eric, Dyhrfjeld‐Johnsen, Jonas, Dyhrfjeld-Johnsen, Jonas

Publikováno v: British Journal of Pharmacology; Feb2020, Vol. 177 Issue 3, p623-633, 11p, 1 Diagram, 3 Graphs

Safety, tolerability, pharmacokinetics and pharmacokinetic‐pharmacodynamic modelling of the novel H4 receptor inhibitor SENS‐111 using a modified caloric test in healthy subjects.

Autor: Venail, Frédéric, Attali, Pierre, Wersinger, Eric, Gomeni, Roberto, Poli, Sonia, Schmerber, Sebastien

Publikováno v: British Journal of Clinical Pharmacology; Dec2018, Vol. 84 Issue 12, p2836-2848, 13p, 5 Charts, 3 Graphs

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