Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Werner Tueckmantel"'
Autor:
Jakub Ptacek, Ivan Snajdr, Jiri Schimer, Zsofia Kutil, Jana Mikesova, Petra Baranova, Barbora Havlinova, Werner Tueckmantel, Pavel Majer, Alan Kozikowski, Cyril Barinka
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4720 (2023)
Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family of enzymes due to its complex domain organization and cytosolic localization. Experimental data point toward the therapeutic use of HDAC6-selective inhibitors (HDAC6is) for use in bo
Externí odkaz:
https://doaj.org/article/bbebe5ebcf174c88906599a07db95e4f
Publikováno v:
ChemMedChem
RAD51 is the central protein in homologous recombination (HR) repair, where it first binds ssDNA and then catalyzes strand invasion via a D-loop intermediate. Additionally, RAD51 plays a role in faithful DNA replication by protecting stalled replicat
Autor:
Sida Shen, Andrew P. Mazar, Werner Tueckmantel, Daniel D. Billadeau, Andrey Ugolkov, Oleksii Dubrovskyi, Alan P. Kozikowski, Jessica Hoffen, Renee A. Schoon, Irina N. Gaisina
Publikováno v:
ChemMedChem. 11:81-92
The histone deacetylases (HDACs) occur in 11 different isoforms, and these enzymes regulate the activity of a large number of proteins involved in cancer initiation and progression. The discovery of isoform-selective HDAC inhibitors (HDACIs) is desir
Autor:
Lucia Motlova, Alan P. Kozikowski, Cyril Bařinka, Werner Tueckmantel, Zora Novakova, Ryo Nakajima
[Image: see text] The design and synthesis of prostate specific membrane antigen (PSMA) ligands derived from 2-aminoadipic acid, a building block that has not previously been used to construct PSMA ligands, are reported. The effects of both the linke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66891e1cf654682fe64d6e22f0e63c20
https://europepmc.org/articles/PMC6231180/
https://europepmc.org/articles/PMC6231180/
Autor:
Anna-Liisa Brownell, Werner Tueckmantel, Aijun Zhu, Meixiang Max Yu, Alan P. Kozikowski, Xukui Wang
Publikováno v:
Nuclear Medicine and Biology. 32:631-640
We have synthesized three different PET ligands to investigate the physiological function of metabotropic glutamate subtype 5 receptors (mGluR5) in vivo: 2-[ 11 C]methyl-6-(2-phenylethynyl)pyridine ([ 11 C]MPEP), 2-(2-(3-[ 11 C]methoxyphenyl)ethynyl)
Publikováno v:
Molecular Cancer Research. 15:PR02-PR02
RAD51 plays a central role in homologous recombination (HR), which maintains genome integrity. RAD51 is commonly overexpressed in cancer cells relative to normal tissue and is considered a therapeutic target in oncology. One potential challenge for t
Autor:
Jarda T. Wroblewski, Sergey Pshenichkin, Alan P. Kozikowski, Shaomeng Wang, Y. Liao, Alexander Surin, C. Thomsen, Werner Tueckmantel
Publikováno v:
ChemInform. 28
Publikováno v:
ChemInform. 29
Autor:
Alan P. Kozikowski, Werner Tueckmantel
Publikováno v:
ChemInform. 30
Autor:
Werner Tueckmantel, Jarda T. Wroblewski, Alan P. Kozikowski, Elena Surina, Gian Luca Araldi, Sergey Pshenichkin
Publikováno v:
ChemInform. 30