Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Werner Rittel"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 37:183-186
CGI 17341 (2-ethyl-5-nitro-2,3-dihydro[2-1b]imidazo-oxazole) is a novel orally active representative of the 5-nitroimidazole series of antimicrobial agents. At concentrations ranging from 0.1 to 0.3 micrograms/ml, CGI 17341 inhibited the drug-suscept
Autor:
T. Shrinivasan, N. Vishvanathan, Dilip R. Ashtekar, Ramnath Iyyer, Werner Rittel, Rabi Costa-Periera
Publikováno v:
Diagnostic Microbiology and Infectious Disease. 14:465-471
DL-S-n-(3-(4-acetyl)-2-oxo-5-oxazolidynyl methyl) acetamide (DuP-721) is an orally active representative of the oxazolidinone series of antimicrobials. At concentrations ranging from 1.5 to 4 micrograms/ml, DuP-721 inhibited equally the strains of My
Publikováno v:
Helvetica Chimica Acta. 63:2358-2363
Cystine peptides are conveniently prepared from S-acetamidomethyl- or S-trityl-protected cysteine derivatives by direct oxidation with iodine. Since the reaction proceeds through the formation of sulfenyl iodides, these highly reactive groups may sub
Autor:
Werner Rittel, Maxine McCALL, Guy Dodson, Hans-Gregor Gattner, U. Glatter, Waleed Danho, Axel Wollmer, Wolfgang Strassburger, Dietrich Brandenburg
Publikováno v:
Hoppe-Seyler´s Zeitschrift für physiologische Chemie. 362:581-592
In 1979 the first abnormal human insulin was discovered. With the minute samples from the patient a Phe leads to Leu replacement could be established in either position B24 or B25. For the unequivocal localization of the substitution both the Leu ana
Publikováno v:
Helvetica Chimica Acta. 60:27-37
Total synthesis of human insulin. IV. Description of the final steps. Recently a preliminary account was given of a new synthetic pathway leading to human insulin. In the present report the last steps of this synthesis – i.e. as from the unsymmetri
Autor:
Werner Rittel, K. Eisler, Bernhard Riniker, Peter Sieber, Hans Rink, Albert Hartmann, Bruno Kamber
Publikováno v:
Helvetica Chimica Acta. 63:899-915
Previously reported studies of the iodine oxidation of S-trityl-cysteine peptides and S-acetamidomethyl-cysteine peptides, leading directly to cystine peptides, have been extended. Detailed investigations have been made of the reactivities of the S-t
Publikováno v:
Hormone and Metabolic Research. 7:511-514
The calcitonin analogues [Val8] -HCT and [Tyr22] -HCT, each with a single modification, and [Val8, Tyr22] -HCT and [Bmp1, Val8] -HCT, with two replaced amino acids were compared with synthetic human calcitonin (HCT) in respect of their hypocalcemic e
Publikováno v:
Helvetica Chimica Acta. 59:2830-2840
Synthesis of human insulin. III. Preparation of the A(14-21) - B(17-30) fragment. In the recently published total synthesis of human insulin [1], one of the three principal intermediates is the protected fragment in which sequence 14-21 of the A chai
Publikováno v:
FEBS Letters. 48:68-71
Autor:
K. Eisler, Werner Rittel, Bernhard Riniker, Bruno Kamber, Peter Sieber, Märki F, M. de Gasparo
Publikováno v:
Bioorganic Chemistry. 8:443-450
Five analogs of human insulin with d -Cys in different positions (A 6 , A 7 , A 11 , A 6+11 , B 7 ) have been synthesized by the fragment condensation approach, combined with selective disulfide formation. All of them have physicochemical properties