Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Werner Risau"'
Autor:
Werner Risau, Gabor M. Rubanyi
The cardiovascular system is the first functional organ system to develop in the vertebrate embryo. Embryonic growth and differentiation essentially depend on transport of nutrients and waste through the early vasculature, and certain events in morph
Autor:
Axinia Döring, Bénédicte Dehouck, Werner Risau, Britta Engelhardt, Silke Tauber, Urban Deutsch, Thorsten M. Schlaeger
Publikováno v:
Experimental Cell Research. 314:1202-1216
Utilizing both the TET-OFF and TET-ON systems in combination with transcriptional control elements of the Tie-2 gene, we have established a series of transgenic activator and responder mice for TET-regulated endothelial cell-specific transgene expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7dfc5db53a8dc83071bb2147beb2db
https://doi.org/10.1016/j.yexcr.2007.12.026
https://doi.org/10.1016/j.yexcr.2007.12.026
Autor:
Moritz A. Konerding, Michael Walker, Alexander J E Foss, Hannes C.A. Drexler, Werner Risau, Catrin S. Rutland, Muneeb Nasir, Holger Gerhardt, Christopher A. Mitchell, Christine Stewart
Publikováno v:
Angiogenesis. 9:209-224
Formation of a correctly organised vasculature and subsequently embryonic survival is critically dependent on the dosage and site-specific expression of VEGF. Murine VEGF exists in three common isoforms (viz. 120, 164 and 188 amino acids) having diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244e1795d7315e4f49ff1546098be967
https://doi.org/10.1007/s10456-006-9056-7
https://doi.org/10.1007/s10456-006-9056-7
Autor:
Gesa Rascher-Eggstein, Karen Wolburg-Buchholz, Stefan Liebner, Frank Duffner, Ernst-H. Grote, Stefan Hamm, Jörg Kraus, Werner Risau, Britta Engelhardt, Hartwig Wolburg
Publikováno v:
Acta Neuropathologica. 105:586-592
In the central nervous system (CNS) complex endothelial tight junctions (TJs) form a restrictive paracellular diffusion barrier, the blood-brain barrier (BBB). During inflammation, BBB properties are frequently lost, resulting in brain edema. To inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ef24eb79b84e9b269345ea461b3ddc
https://doi.org/10.1007/s00401-003-0688-z
https://doi.org/10.1007/s00401-003-0688-z
Autor:
Georg Breier, Sabine Blum, Ernst Reichmann, Marcel Groot, Janos Peli, Carola Wild, Werner Risau
Publikováno v:
International Journal of Cancer. 97:142-148
The formation of new microvasculature by capillary sprouting, or angiogenesis, is a prerequisite for solid tumor growth. The genetic alterations required to activate the angiogenic program in tumor angiogenesis are still only vaguely known, but domin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3d4cd3f2eca8968e0c2f85709e366a
https://doi.org/10.1002/ijc.1599
https://doi.org/10.1002/ijc.1599
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1518:57-62
Sequencing of rat and human vascular endothelial growth factor (VEGF) cDNA clones has previously identified a 3' untranslated region of approximately 1.9 kb, although the apparent site of polyadenylation differed in the two species, despite a high de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651e4fcf56465ccb0e796e68a6248387
https://doi.org/10.1016/s0167-4781(01)00167-1
https://doi.org/10.1016/s0167-4781(01)00167-1
Publikováno v:
International Journal of Cancer. 91:273-282
Tumor growth is angiogenesis-dependent. Current evidence suggests that vascular endothelial growth factor (VEGF), a major regulator of embryonic and hypoxia-mediated angiogenesis, is necessary for tumor angiogenesis. VEGF is expressed in tumor cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3e739470c459d8dc9e4315e3849938
https://doi.org/10.1002/1097-0215(200002)9999:9999<::aid-ijc1054>3.0.co
https://doi.org/10.1002/1097-0215(200002)9999:9999<::aid-ijc1054>3.0.co
Autor:
Klaus Willecke, Olaf Krüger, Ulrich Pohl, Thorsten M. Schlaeger, C. de Wit, Urban Deutsch, Britta Döring, Dominik Eckardt, Werner Risau, Martin Theis
Publikováno v:
genesis. 29:1-13
The murine gap junction protein connexin43 (Cx43) is expressed in blood vessels, with vastly different contribution by endothelial and smooth muscle cells. We have used the Cre recombinase under control of TIE2 transcriptional elements to inactivate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828b9e19c28267b5f63d07ec188e83c7
https://doi.org/10.1002/1526-968x(200101)29:1<1::aid-gene1000>3.0.co
https://doi.org/10.1002/1526-968x(200101)29:1<1::aid-gene1000>3.0.co
Publikováno v:
Oncogene. 18:5948-5953
During development of the vertebrate vascular system essential signals are transduced via protein-tyrosine phosphorylation. Null-mutations of receptor-tyrosine kinase (RTK) genes expressed in endothelial cells (ECs) display early lethal vascular phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13cc8e523b11f93e30317b89e5b3db2
https://doi.org/10.1038/sj.onc.1202992
https://doi.org/10.1038/sj.onc.1202992