Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Werner Pachinger"'
Publikováno v:
Organic Process Research & Development. 23:1908-1917
The development of the robust synthesis of 2-methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]-phenyl]propionitrile (dactolisib) on a commercial scale is des...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94502eb1f06a340324824bbfab8df4a1
https://doi.org/10.1021/acs.oprd.9b00221
https://doi.org/10.1021/acs.oprd.9b00221
Publikováno v:
Organic Process Research & Development. 7:436-445
5-[2-Methoxy-5-(4-pyridinyl)phenyl]-2,1,3-benzoxadiazole (PDE472) is a selective inhibitor of the phosphodiesterase PDE4D isoenzyme, which is a recognised drug target for the treatment of asthma. Different synthetic routes to PDE472 were investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5944fbb36273c684c9a8c222a0d62ad0
https://doi.org/10.1021/op025615q
https://doi.org/10.1021/op025615q
Publikováno v:
ChemInform. 21
Trans-cyclization products were selectively formed from C-6-substituted acetoxy-octadienes only via Ni(0) catalysis ( 1 → 2 ) and from C-4-substituted analogs under Pd(0)- and Ni(0) catalysis ( 7 , 8 → 9 ). C-5-Substituted precursors gave mixture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51755e4a15867d6dc8a996d2078bfbd5
https://doi.org/10.1002/chin.199049096
https://doi.org/10.1002/chin.199049096
Publikováno v:
Tetrahedron Letters, Vol. 31, No 9 (1990) pp. 1265-1268
Trans-cyclization products were selectively formed from C-6-substituted acetoxy-octadienes only via Ni(0) catalysis ( 1 → 2 ) and from C-4-substituted analogs under Pd(0)- and Ni(0) catalysis ( 7 , 8 → 9 ). C-5-Substituted precursors gave mixture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cff4d11662aa979e79b5b9e85a1a702
https://archive-ouverte.unige.ch/unige:152795
https://archive-ouverte.unige.ch/unige:152795
Publikováno v:
Helvetica chimica acta, Vol. 69, No 7 (1986) pp. 1542-1545
EtAlCl2-promoted additions of organocopper reagents to camphor-derived, conjugated N-enoyl-sultams gave saturated and olefinic β-silylcarboxyl derivatives with high diastereodifferentiation. Nondestructive removal of the chiral auxiliary followed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9014e85a7b71642aebb5bff60d2dcb
https://doi.org/10.1002/hlca.19860690703
https://doi.org/10.1002/hlca.19860690703
Publikováno v:
Helvetica Chimica Acta, Vol. 72, No 1 (1989) pp. 14-16
Dienyl acetates 2 lacking a geminal disulfone or a malonate group cyclize selectively to (E)-l-methylidene-2-styrylcyclopentanes 4 in the presence of 7 mol-% of [Pd(PPh₃)₄].
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873916fe4e20734c06389d9aa7d4c23a
https://doi.org/10.1002/hlca.19890720103
https://doi.org/10.1002/hlca.19890720103
Publikováno v:
ChemInform. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4636ef6f19319dbc64be5b30c475f710
https://doi.org/10.1002/chin.198708250
https://doi.org/10.1002/chin.198708250