Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Werner Mewes"'
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007613 (2020)
There is an increasing need to use genome and transcriptome sequencing to genetically diagnose patients suffering from suspected monogenic rare diseases. The proper detection of compound heterozygous variant combinations as disease-causing candidates
Externí odkaz:
https://doaj.org/article/e07d9376c1494f1bbb913a615ee66c6d
Autor:
Angela Adler, Pia Kirchmeier, Julian Reinhard, Barbara Brauner, Irmtraud Dunger, Gisela Fobo, Goar Frishman, Corinna Montrone, H.-Werner Mewes, Matthias Arnold, Andreas Ruepp
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 13, Iss 1, Pp 1-8 (2018)
Abstract Background Thoroughly annotated data resources are a key requirement in phenotype dependent analysis and diagnosis of diseases in the area of precision medicine. Recent work has shown that curation and systematic annotation of human phenome
Externí odkaz:
https://doaj.org/article/b8e4382893a74c09b45949f5d840b90a
Autor:
Rouzanna Istvánffy, Baiba Vilne, Christina Schreck, Franziska Ruf, Charlotta Pagel, Sandra Grziwok, Lynette Henkel, Olivia Prazeres da Costa, Johannes Berndt, Volker Stümpflen, Katharina S. Götze, Matthias Schiemann, Christian Peschel, Hans-Werner Mewes, Robert A.J. Oostendorp
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 702-715 (2015)
Hematopoietic stem cells (HSCs) are preserved in co-cultures with UG26-1B6 stromal cells or their conditioned medium. We performed a genome-wide study of gene expression changes of UG26-1B6 stromal cells in contact with Lineage− SCA-1+ KIT+ (LSK) c
Externí odkaz:
https://doaj.org/article/ac1089625849491da128937c05b4267c
Autor:
Wolfgang Schweiger, Jean-Claude Pasquet, Thomas Nussbaumer, Maria Paula Kovalsky Paris, Gerlinde Wiesenberger, Catherine Macadré, Christian Ametz, Franz Berthiller, Marc Lemmens, Patrick Saindrenan, Hans-Werner Mewes, Klaus F. X. Mayer, Marie Dufresne, Gerhard Adam
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 26, Iss 7, Pp 781-792 (2013)
Plant small-molecule UDP-glycosyltransferases (UGT) glycosylate a vast number of endogenous substances but also act in detoxification of metabolites produced by plant-pathogenic microorganisms. The ability to inactivate the Fusarium graminearum mycot
Externí odkaz:
https://doaj.org/article/a8d5d864c7864790becd974e9fb2cdcc
Autor:
Hans‐Werner Mewes
Publikováno v:
Yeast. 36:161-165
From 1989 to 1997, the yeast genome was sequenced by a worldwide international consortium initiated and conducted by André Goffeau (1935-2018). The article describes the pioneering collaboration of yeast scientists from a bioinformatics perspective.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde31df865b28095f02d74bbcaec70f7
https://doi.org/10.1002/yea.3378
https://doi.org/10.1002/yea.3378
Autor:
Christian M K Sieber, Wanseon Lee, Philip Wong, Martin Münsterkötter, Hans-Werner Mewes, Clemens Schmeitzl, Elisabeth Varga, Franz Berthiller, Gerhard Adam, Ulrich Güldener
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110311 (2014)
Fungal secondary metabolite biosynthesis genes are of major interest due to the pharmacological properties of their products (like mycotoxins and antibiotics). The genome of the plant pathogenic fungus Fusarium graminearum codes for a large number of
Externí odkaz:
https://doaj.org/article/503f626aa50e4cceb585784bd445d0d0
Autor:
Jan Krauß, Michael Breitenbach, Michael Wießner, Jan Schernthaner, Hannelore Breitenbach-Koller, Christian Manuel Kitzler, Thomas Karl, Friedrich Lottspeich, H Hintner, Jörg von Hagen, Petr Rathner, Werner Mewes, Norbert Müller, Johann W. Bauer, Adriana Rathner, Andreas Friedrich
Publikováno v:
Skin pharmacology and physiology. 34(4)
Introduction: Epidermolysis bullosa (EB) describes a family of rare genetic blistering skin disorders. Various subtypes are clinically and genetically heterogeneous, and a lethal postpartum form of EB is the generalized severe junctional EB (gs-JEB).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d61ffc733c9ace9c3d35c641da7149
https://pubmed.ncbi.nlm.nih.gov/33823521
https://pubmed.ncbi.nlm.nih.gov/33823521
Autor:
Clemens Schmeitzl, Elisabeth Varga, Benedikt Warth, Karl G. Kugler, Alexandra Malachová, Herbert Michlmayr, Gerlinde Wiesenberger, Klaus F. X. Mayer, Hans-Werner Mewes, Rudolf Krska, Rainer Schuhmacher, Franz Berthiller, Gerhard Adam
Publikováno v:
Toxins, Vol 8, Iss 1, p 6 (2015)
Increasing frequencies of 3-acetyl-deoxynivalenol (3-ADON)-producing strains of Fusarium graminearum (3-ADON chemotype) have been reported in North America and Asia. 3-ADON is nearly nontoxic at the level of the ribosomal target and has to be deacety
Externí odkaz:
https://doaj.org/article/3f30044d17cf4c4bb26d89e5dbe51768
Autor:
Barbara Brauner, Irmtraud Dunger, Julian Reinhard, Matthias Arnold, Andreas Ruepp, Goar Frishman, Corinna Montrone, H. Werner Mewes, Angela Adler, Pia Kirchmeier, Gisela Fobo
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 13, Iss 1, Pp 1-8 (2018)
Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases
Thoroughly annotated data resources are a key requirement in phenotype dependent analysis and diagnosis of diseases in the area of precision medicine. Recent work has shown that curation and systematic annotation of human phenome data can significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fccd4d983af757b447cb078679c6326
http://link.springer.com/article/10.1186/s13023-018-0765-y
http://link.springer.com/article/10.1186/s13023-018-0765-y
Autor:
Karsten Suhre, Christa Meisinger, Angela Döring, Elisabeth Altmaier, Petra Belcredi, Christian Gieger, David Chang, Michael V Milburn, Walter E Gall, Klaus M Weinberger, Hans-Werner Mewes, Martin Hrabé de Angelis, H-Erich Wichmann, Florian Kronenberg, Jerzy Adamski, Thomas Illig
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13953 (2010)
BACKGROUND: Metabolomics is the rapidly evolving field of the comprehensive measurement of ideally all endogenous metabolites in a biological fluid. However, no single analytic technique covers the entire spectrum of the human metabolome. Here we pre
Externí odkaz:
https://doaj.org/article/bcb5d252a31940179a90efd756bcbc38