Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Werner Löwe"'
Autor:
Werner Löwe, Anja Lüth
Publikováno v:
Journal of Heterocyclic Chemistry. 45:703-708
The epidermal growth factor (EGF) family of membrane receptors has been identified as a key element in the complex signaling network that is utilized by various classes of cell-surface receptors. A new synthetic pathway of 4-(indol-3-yl)quinazolines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42b18d9978e302a70f37f51923f3f09c
https://doi.org/10.1002/jhet.5570450311
https://doi.org/10.1002/jhet.5570450311
Autor:
Werner Reutter, Frédéric Cantagrel, Michael Mickeleit, Stephan Laabs, Burkhard Kleuser, Werner Löwe, Annette Fischer, Martin Zimmermann-Kordmann, Dieter Dr. Müller, Kerstin Danker
Publikováno v:
ChemBioChem. 7:441-449
The search for specific anticancer drugs that do not interfere with DNA synthesis or influence the cytoskeleton has led to the development of modified phospholipids with antiproliferative properties. These compounds cause remodeling of the structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf99f0a05a2c873a255c51999fdef38
https://doi.org/10.1002/cbic.200500336
https://doi.org/10.1002/cbic.200500336
Publikováno v:
Journal of Heterocyclic Chemistry. 38:365-370
Under basic conditions 2,6-bis(bromomethyl)-4-pyrone 8 reacts with tetraethylene glycol to yield the unexpected macrocycle 9, which is related to the antibiotic Kjellmanianone 10. We propose that this ring transformation proceeds via the cyclopropyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c234b9e3e8c50e79be5c45767c89365
https://doi.org/10.1002/jhet.5570380208
https://doi.org/10.1002/jhet.5570380208
Autor:
Werner Löwe, Thomas Braden
Publikováno v:
Archiv der Pharmazie. 324:949-951
Die bisher unbekannten 1,3,2-Benzodioxathiine 5, 6 werden aus den Enaminonen 1, 2 durch Reaktion mit Chlorsulfonsaure oder Oleum erhalten. Die Verbindungen 5, 6 lassen sich in die Oxime 7, 8, in die Oximester 11, 12, in die 2,4-Dinitrophenylhydrazone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bc7a65187fdf4e5677c015631723aa4
https://doi.org/10.1002/ardp.2503241202
https://doi.org/10.1002/ardp.2503241202
Autor:
Norbert Matzanke, Holger Stark, Sylvie Perachon, Pierre Sokoloff, Werner Löwe, Jean-Charles Schwartz
Publikováno v:
European Journal of Medicinal Chemistry. 34:791-798
With a straightforward seven-step synthesis, racemic perhydro[1,4]benzoxazin-6-on was synthesized in overall good yields via regioselective epoxid ring-opening to the corresponding β-aminoalcohol. The oxazine derivative was the key intermediate for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6970d756b912aaf4b926b4e6f65b6e29
https://doi.org/10.1016/s0223-5234(99)00213-5
https://doi.org/10.1016/s0223-5234(99)00213-5
Publikováno v:
Journal of Heterocyclic Chemistry. 34:1173-1178
We report here the syntheses and characterization of new crown-type compounds 8 and 9 incorporated with one and two 4-pyrone units. The reaction of compound 3 with 1,5-bis(2-hydroxyphenoxy)-3-oxapentane or catechol gave the desired molecules 8 and 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70cb451b15d941ac0d5fd7f4dfca003f
https://doi.org/10.1002/jhet.5570340413
https://doi.org/10.1002/jhet.5570340413
Autor:
Norbert Matzanke, Werner Löwe
Publikováno v:
Journal of Heterocyclic Chemistry. 33:763-766
We examined the scope of the previously reported one-pot synthesis [1] of chromone-3-sulfonylureas. Different anilines and heterocyclic amines were thereby reacted with chlorosulfonyl isocyanate-derived chlorosulfonylureas. These were treated with di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::863393f9abf62986d0761e3b47fe0b16
https://doi.org/10.1002/jhet.5570330340
https://doi.org/10.1002/jhet.5570330340
Autor:
Werner Löwe, Norbert Matzanke
Publikováno v:
Journal of Heterocyclic Chemistry. 33:943-948
The synthesis of new flavone-3-sulfonylurea derivatives is hereby described. The influence of a phenyl group in the 2-position and an acetate group in the 8-position at the chromone nucleus on the activity was studied. Only weak cytostatic activity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01e99687ab46d3ac1fcd1266d18cfee1
https://doi.org/10.1002/jhet.5570330364
https://doi.org/10.1002/jhet.5570330364
Publikováno v:
Journal of Heterocyclic Chemistry. 32:249-254
The new, fluorinated benzoxathiinopyrazole 4 and the hitherto unknown fluorinated benzoxathiinodihydropyridine 5 can be produced by reacting the title compound 1 with cyanoacetic hydrazide (3) in the presence of sodium acetate. The structures of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94f0a9a7053c554a387c48dfa1b4651b
https://doi.org/10.1002/jhet.5570320142
https://doi.org/10.1002/jhet.5570320142
Autor:
Werner Löwe, Annette Kietzmann
Publikováno v:
Archiv der Pharmazie. 328:11-15
Ausgehend vom tosylierten Enaminon 5 lassen sich mit Essigsaure, Sulfurylchlorid und Thionylchlorid die neuen Chinolon-Derivate 3, 8, 9 und 10 herstellen. Das schwefelverbruckte Bischinolon 8 gibt bei der Alkylierung die N-Alkylprodukte 11 und 12. Di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c306320cc607f9f78059f39016b8dcb
https://doi.org/10.1002/ardp.19953280104
https://doi.org/10.1002/ardp.19953280104