Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Werner Klaffke"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 1619-1636 (2018)
The Mitsunobu reaction basically consists in the conversion of an alcohol into an ester under inversion of configuration, employing a carboxylic acid and a pair of two auxiliary reagents, mostly triphenylphosphine and a dialkyl azodicarboxylate. This
Externí odkaz:
https://doaj.org/article/51622cd2e4cd4f5299bd1295415b6ea1
Autor:
Alexios Koutsoukas, John B. O. Mitchell, Robert C. Glen, Werner Klaffke, Yasaman KalantarMotamedi, Andreas Bender, Robert Lowe, Hamse Y. Mussa
Publikováno v:
Journal of Chemical Information and Modeling. 53:1957-1966
In this study, two probabilistic machine-learning algorithms were compared for in silico target prediction of bioactive molecules, namely the well-established Laplacian-modified Naïve Bayes classifier (NB) and the more recently introduced (to Chemin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44fc7ee1a5371e9bb5fecd0085af47c5
https://doi.org/10.1021/ci300435j
https://doi.org/10.1021/ci300435j
Autor:
Andrew Howlett, Daniel S. Murrell, Leo van Buren, Johannes Kirchmair, Mark J. Williamson, Thomas Hankemeier, Robert C. Glen, Guus Duchateau, Julio E. Peironcely, Werner Klaffke, Samuel E. Adams
Publikováno v:
Journal of Chemical Information and Modeling. 53:354-367
Understanding which physicochemical properties, or property distributions, are favorable for successful design and development of drugs, nutritional supplements, cosmetics, and agrochemicals is of great importance. In this study we have analyzed mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5046e4cb8b1577ec372c3eeae3fd53
https://doi.org/10.1021/ci300487z
https://doi.org/10.1021/ci300487z
Autor:
Alexios Koutsoukas, Robert Lowe, Yasaman KalantarMotamedi, Hamse Y. Mussa, Werner Klaffke, John B. O. Mitchell, Robert C. Glen, Andreas Bender
Publikováno v:
Journal of Chemical Information and Modeling. 54:2180-2182
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2ccc2a83b6ec249ad154a4637e6ea65
https://doi.org/10.1021/ci500255v
https://doi.org/10.1021/ci500255v
Publikováno v:
Journal of Agricultural and Food Chemistry. 58:1327-1332
The use of heme analogues from vegetable origin could provide an alternative iron source of potentially high bioavailability. Sodium iron chlorophyllin is a water-soluble semisynthetic chlorophyll derivative where the magnesium in the porphyrin ring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b4411b7bc34def823decdfa0fb9886
https://doi.org/10.1021/jf903177q
https://doi.org/10.1021/jf903177q
Publikováno v:
Journal of Food Science. 74:H243-H251
Selected di- and tripeptides exhibit angiotensin-I converting enzyme (ACE) inhibitory activity in vitro. However, the efficacy in vivo is most likely limited for most peptides due to low bioavailability. The purpose of this study was to identify desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd45e5bd50522bfbdb9c3596bde7c981
https://doi.org/10.1111/j.1750-3841.2009.01301.x
https://doi.org/10.1111/j.1750-3841.2009.01301.x
Autor:
Guus Duchateau, Werner Klaffke
Publikováno v:
Food Biophysics. 3:207-212
Bioavailability is the fraction of an administered dose that reaches the systemic circulation. Health claims for functional foods can only be made if the ingredient reaches the target site to trigger the physiological action, hence substantiation req
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c197de3719aea96cb0b159cf532feaa
https://doi.org/10.1007/s11483-008-9076-5
https://doi.org/10.1007/s11483-008-9076-5
Publikováno v:
Current Nutrition & Food Science. 4:44-52
Iron deficiency is the most common nutritional disorder in the world. It is estimated that 2 billion people are anaemic. Approximately 50% of infants, school-age children and women of reproductive age suffer from iron deficiency anaemia in some count
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b2328a95d7e8f17c804cbc054f27163
https://doi.org/10.2174/157340108783497436
https://doi.org/10.2174/157340108783497436
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 3:545-556
The abundance of different techniques and protocols available reflects the need for reliable in vitro methods to assess intestinal absorption of potentially bioactive compounds. Physicochemical assays try to pinpoint the molecular properties contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427bf10106767cce228b7f3fbdb9e238
https://doi.org/10.1517/17425255.3.4.545
https://doi.org/10.1517/17425255.3.4.545
Autor:
Werner Klaffke, Andrew Howlett, David Marcus, Robert C. Glen, Guus Duchateau, Lora Mak, Galina Yarova, Andreas Bender
Publikováno v:
Journal of Cheminformatics
Both metabolism and transport are key elements defining the bioavailability and biological activity of molecules, i.e. their adverse and therapeutic effects. Structured and high quality experimental data stored in a suitable container, such as a rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5863e0f83d5444000fc1b2306c8fe7a6
http://europepmc.org/articles/PMC4477067
http://europepmc.org/articles/PMC4477067