Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Werner Kiefer"'
Autor:
Lina Irsheid, Thomas Wehler, Christoph Borek, Werner Kiefer, Ruth Brenk, Maria Elena Ortiz-Soto, Jürgen Seibel, Tanja Schirmeister
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216132 (2019)
Golgi α-mannosidase II (GMII) is a glycoside hydrolase playing a crucial role in the N-glycosylation pathway. In various tumour cell lines, the distribution of N-linked sugars on the cell surface is modified and correlates with the progression of tu
Externí odkaz:
https://doaj.org/article/4c10653b62ac42bd84921c63fc111225
Autor:
Fabian Barthels, Melissa Immerheiser, Michael Basic, Nathalie Jung, Jochen Bodem, Andrea Gellert, Christian Kersten, Tanja Schirmeister, Werner Kiefer, Ute A. Hellmich, Stefan Hammerschmidt, Eberhard Hildt, Fabian Elgner, Maike Windbergs, Benedikt Millies, Ulrike Göppel, Franziska von Hammerstein
Publikováno v:
Journal of Medicinal Chemistry. 62:11359-11382
The NS2B/NS3 serine proteases of the Zika and Dengue flaviviruses are attractive targets for the development of antiviral drugs. We report the synthesis and evaluation of a new, proline-based compound class that displays allosteric inhibition of both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff917177811dc90b36f1466e2bf606c
https://doi.org/10.1021/acs.jmedchem.9b01697
https://doi.org/10.1021/acs.jmedchem.9b01697
Autor:
Werner Kiefer, Philipp Fey, Tanja Schirmeister, Jeremy C. Mottram, Roula Chartomatsidou, Christian Kersten
Publikováno v:
European Journal of Medicinal Chemistry. 156:587-597
In the present work a series of aziridine-2,3-dicarboxylate inhibitors of papain-like cysteine proteases was designed, synthesized and tested. The compounds displayed selectivity for the parasitic protozoon Leishmania mexicana cathepsin L-like cystei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eacfb8edca1dfd3d9a82ca842c8321a
https://doi.org/10.1016/j.ejmech.2018.07.012
https://doi.org/10.1016/j.ejmech.2018.07.012
Autor:
Werner Kiefer, Holger Ulbrich, Jan-Peter Kramb, Gerd Dannhardt, Andreas Mattern, Michael Scholz
Publikováno v:
Archiv der Pharmazie. 341:281-287
The aim was to study the COX-1 inhibiting efficacy in context with hydroxyl radical scavenging properties of compounds bearing a carboxylic acid and ester function, respectively. In general, the acids are more potent radical scavengers than the corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9048c201c63ca19b87e272660994bb50
https://doi.org/10.1002/ardp.200700247
https://doi.org/10.1002/ardp.200700247
Autor:
Werner Kiefer, Gerd Dannhardt
Publikováno v:
Pharmazie in unserer Zeit. 36:306-310
Unbestritten ist, dass sich durch den Einsatz von Antiepileptika der 2. Generation die Situation fur Epilepsiepatienten entscheidend verbessert hat. Dennoch bleibt ein Patientenklientel, bei dem keine ausreichende Anfallskontrolle erreicht wird, das
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1674d3986e57fc10bb293a2174b7e9d5
https://doi.org/10.1002/pauz.200600229
https://doi.org/10.1002/pauz.200600229
Autor:
Gerd Dannhardt, Werner Kiefer
Publikováno v:
Pharmazie in unserer Zeit. 36:270-281
Bereits im altesten bekannten Schrifttext der Menschheit, dem Gesetzeskodex von Hammurabi (1728 bis 1686 v. Chr.), wurde die Epilepsie erwahnt. In der Antike als “Heilige Krankheit” charakterisiert ist die Epilepsie die haufigste chronisch neurol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85c5d2b74915b5cc6134a7cd43c492d2
https://doi.org/10.1002/pauz.200600225
https://doi.org/10.1002/pauz.200600225
Autor:
Tanja Schirmeister, Paulo C. Vieira, Liliane Nebo, Hongmei Wu, Werner Kiefer, João B. Fernandes, Lorena R.F. de Sousa, Maria Fátima das Graças Fernandes da Silva
Publikováno v:
Experimental parasitology. 156
Cysteine proteinases (cathepsins) from Leishmania spp. are promising molecular targets against leishmaniasis. Leishmania mexicana cathepsin L is essential in the parasite life cycle and a pivotal in virulence factor in mammals. Natural products that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e967b879bc9b713ddd1ba6278245ef
https://pubmed.ncbi.nlm.nih.gov/26044356
https://pubmed.ncbi.nlm.nih.gov/26044356
Autor:
Gerd Dannhardt, Werner Kiefer
Publikováno v:
Expert Review of Clinical Immunology. 1:431-442
Cyclooxygenase-2 selective inhibitors have long been regarded as potent anti-inflammatory drugs for the treatment of arthritis, osteoarthritis and dysmenorrhea. The reports of cardiovascular risk and the subsequent withdrawal of rofecoxib, and recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae352e6c4fdaad1d1f21dd7b763eb6d
https://doi.org/10.1586/1744666x.1.3.431
https://doi.org/10.1586/1744666x.1.3.431
Autor:
Gerd Dannhardt, Werner Kiefer
Publikováno v:
Current Medicinal Chemistry. 11:3147-3161
The discovery of the two isoenzymes COX-1 and COX-2 and the knowledge of their function, localisation and regulation has initiated the development of COX-2 selective inhibitors (coxibs). Inducible COX-2 at the peripheral site of inflammation has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738a34c7119762f3e3e32c7d2c2fe701
https://doi.org/10.2174/0929867043363668
https://doi.org/10.2174/0929867043363668
Bei der Altlastensanierung liegt einiges im argen, nicht zuletzt die mangelnde Qualität der Planer- und Gutachterleistungen. Da die Honorarordnung für Architekten und Ingenieure (HOAI) den Bereich Altlastensanierung punktuell erfaßt, werden Honora
