Zobrazeno 1 - 10 of 149 pro vyhledávání: '"Werner K. Lutz"'
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Akademický článek
CYP2C9 genotype vs. metabolic phenotype for individual drug dosing--a correlation analysis using flurbiprofen as probe drug.
Autor: Silvia Vogl, Roman W Lutz, Gilbert Schönfelder, Werner K Lutz
Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0120403 (2015)
Currently, genotyping of patients for polymorphic enzymes responsible for metabolic elimination is considered a possibility to adjust drug dose levels. For a patient to profit from this procedure, the interindividual differences in drug metabolism wi
Externí odkaz: https://doaj.org/article/326b566bca5b48e2a52f66118939dc0e
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5
Covalent binding of styrene to DNA in rat and mouse
Autor: Werner K. Lutz, Sergio Cantoreggi
Covalent binding of [7-3H]styrene (S) to DNA in vivo was measured and evaluated in a quantitative manner in order to investigate whether DNA adduct formation could form a mechanistic basis for tumor induction in a carcinogenicity bioassay. [7-3H]S wa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d46986de397a89047e7459607b2b39b
http://doc.rero.ch/record/302192/files/14-3-355.pdf
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6
Mouse skin papilloma formation by chronic dermal application of 7, 12-dimethylbenz[a] anthracene is not reduced by diet restriction
Autor: Werner K. Lutz, Wolfgang H. Fischer
Diet restriction has repeatedly been shown to reduce the incidence of spontaneous and chemically induced tumors in rodents. However, no conclusive data are available to show whether carcinogenesis by chronic exposure to a genotoxic agent can also be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70216c67e625ce01661252a28a3d8fc4
http://doc.rero.ch/record/298884/files/15-1-129.pdf
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7
Drug interactions with mitotane by induction of CYP3A4 metabolism in the clinical management of adrenocortical carcinoma
Autor: Matthias Kroiss, Werner K. Lutz, Bruno Allolio, Martin Fassnacht, Marcus Quinkler
Publikováno v: Clinical Endocrinology. 75:585-591
Mitotane [1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, (o,p'-DDD)] is the only drug approved for the treatment for adrenocortical carcinoma (ACC) and has also been used for various forms of glucocorticoid excess. Through still largely un
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a04299de273699990d7730b5aa61d962
https://doi.org/10.1111/j.1365-2265.2011.04214.x
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8
The Viracept (nelfinavir)—Ethyl methanesulfonate case☆A threshold risk assessment for human exposure to a genotoxic drug contamination?
Autor: Werner K. Lutz
Publikováno v: Toxicology Letters. 190:239-242
In May 2007, the F. Hoffmann-La Roche Company became aware of a contamination of Viracept (nelfinavir) tablets by the mutagenic DNA-ethylating agent ethyl methanesulfonate (EMS) as a result of a production incident. HIV-patients could have been expos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9c59101ad4509dc4969a9107dbf778
https://doi.org/10.1016/j.toxlet.2009.07.032
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9
Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose–response relationships, exemplified for mutagenicity data
Autor: Roman W. Lutz, Werner K. Lutz
Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 678:118-122
Strongly sublinear dose-response relationships (slope increasing with dose) raise the question about a putative threshold dose below which no biologically relevant effect would be expected. A mathematical threshold with a break in the curve at the th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28a8415f99cd93bf22bd08de2e7d8af
https://doi.org/10.1016/j.mrgentox.2009.05.010
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10
CYP2C9 Genotype vs. Metabolic Phenotype for Individual Drug Dosing—A Correlation Analysis Using Flurbiprofen as Probe Drug
Autor: Roman W. Lutz, Gilbert Schönfelder, Silvia Vogl, Werner K. Lutz
Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 3, p e0120403 (2015)
PLoS ONE, 10 (3)
Currently, genotyping of patients for polymorphic enzymes responsible for metabolic elimination is considered a possibility to adjust drug dose levels. For a patient to profit from this procedure, the interindividual differences in drug metabolism wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73006fd25199e95dd1a38de29c0479f7
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