Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Werner Hummel"'
Autor:
Gröger, Daniel Bakonyi, Christine Toelzer, Michael Stricker, Werner Hummel, Karsten Niefind, Harald
Publikováno v:
Catalysts; Volume 10; Issue 11; Pages: 1281
Alcohol dehydrogenases catalyse the conversion of a large variety of ketone substrates to the corresponding chiral products. Due to their high regio- and stereospecificity, they are key components in a wide range of industrial applications. A novel a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::5285e82d46228e0a1d380342b0d71005
Publikováno v:
European Journal of Organic Chemistry. 2017:812-817
A suitable "process window" was identified for the combination of an asymmetric organocatalytic aldol reaction and subsequent biocatalytic reduction in aqueous medium, which thus enabled the enantio- and diastereoselective synthesis of 1,3-diols in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0b41173f80b34139cc345e07efba5f1
https://doi.org/10.1002/ejoc.201600831
https://doi.org/10.1002/ejoc.201600831
Publikováno v:
Green Chemistry. 19:405-410
Whole-cell catalysts overexpressing two enzymes for a double reduction cascade in which aliphatic alpha-branched alpha,beta-unsaturated aldehydes are converted into Guerbet alcohols as a highly demanded class of lubricants were constructed and charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0dc490f0d22ec41283cbe04dbcb6a36
https://doi.org/10.1039/c6gc01668e
https://doi.org/10.1039/c6gc01668e
Autor:
Anna Reimer, Udo Kragl, Werner Hummel, Harald Gröger, Sandy Schmidt, Svenja Staudt, Severin Wedde, Uwe T. Bornscheuer, Diana Höffer
Publikováno v:
Journal of Heterocyclic Chemistry. 54:391-396
For an alternative synthetic approach toward the heterocyclic industrial chemical e-caprolactone, which is based on a biocatalytic oxidation of readily available cyclohexanol with air in aqueous media (using an alcohol dehydrogenase and a Baeyer–Vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b4b81c1a6558e2d7fd03313a639df94
https://doi.org/10.1002/jhet.2595
https://doi.org/10.1002/jhet.2595
Publikováno v:
ChemBioChem. 17:1349-1358
The stereoselective synthesis of chiral 1,3-diols with the aid of biocatalysts is an attractive tool in organic chemistry. Besides the reduction of diketones, an alternative approach consists of the stereoselective reduction of beta-hydroxy ketones (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4666fdeea9b89ae28346fb4f328a03dd
https://doi.org/10.1002/cbic.201600101
https://doi.org/10.1002/cbic.201600101
Publikováno v:
Organic Process Research & Development. 19:635-638
In this contribution, we report the chemoenzymatic preparation of a key building block for the active pharmaceutical ingredient rosuvastatin, one of the "top 5 blockbuster drugs" with a worldwide market value of 6.25 billion USD in 2012, via a seven-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3811935502eaf19baaf381d46cb66582
https://doi.org/10.1021/acs.oprd.5b00057
https://doi.org/10.1021/acs.oprd.5b00057
Publikováno v:
Advanced Synthesis & Catalysis. 357:1751-1762
Tailor-made strategies for the stereo- and regioselective multi-step enzymatic synthesis of glycoconjugates require well characterized glycosyltransferases and carbohydrate modifying enzymes. We here report on a novel enzyme cascade for the synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c97fabf1fb49c0b4f07e0a9faaf2989
https://doi.org/10.1002/adsc.201500180
https://doi.org/10.1002/adsc.201500180
Publikováno v:
ChemCatChem. 7:1302-1311
In this study an evaluation of the synthetic potential of a broad range of recombinant ene reductases was performed. In detail, a library of 23 ene reductases was used to screen the C=C reduction of 21 activated alkenes from different compound classe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e82e17a5cc1b6be40f9f95c949107d
https://doi.org/10.1002/cctc.201402903
https://doi.org/10.1002/cctc.201402903
Publikováno v:
Angewandte Chemie International Edition. 54:4488-4492
A Wacker oxidation using CuCl/PdCl2 as a catalyst system was successfully combined with an enzymatic ketone reduction to convert styrene enantioselectively into 1-phenylethanol in a one-pot process, although the two reactions conducted in aqueous med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec6ebd30ce8b9586aa03a898b15c0fd
https://doi.org/10.1002/anie.201409590
https://doi.org/10.1002/anie.201409590
Publikováno v:
Angewandte Chemie. 127:4570-4574
Eine Wacker-Oxidation unter Verwendung von CuCl/PdCl2 als Katalysatorsystem wurde erfolgreich mit einer enzymatischen Ketonreduktion zur enantioselektiven Umwandlung von Styrol in 1-Phenylethanol in einem Eintopf-Verfahren kombiniert, obwohl beide im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2190147a454d105b4a7449cf96bb1073
https://doi.org/10.1002/ange.201409590
https://doi.org/10.1002/ange.201409590