Zobrazeno 1 - 10 of 341 pro vyhledávání: '"Werner Hummel"'
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Expanding the Application Range of Microbial Oxidoreductases by an Alcohol Dehydrogenase from Comamonas testosteroni with a Broad Substrate Spectrum and pH Profile
Autor: Gröger, Daniel Bakonyi, Christine Toelzer, Michael Stricker, Werner Hummel, Karsten Niefind, Harald
Publikováno v: Catalysts; Volume 10; Issue 11; Pages: 1281
Alcohol dehydrogenases catalyse the conversion of a large variety of ketone substrates to the corresponding chiral products. Due to their high regio- and stereospecificity, they are key components in a wide range of industrial applications. A novel a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::5285e82d46228e0a1d380342b0d71005
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3
First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols
Autor: Nongnaphat Duangdee, Werner Hummel, Giuseppe Rulli, Harald Gröger, Albrecht Berkessel
Publikováno v: European Journal of Organic Chemistry. 2017:812-817
A suitable "process window" was identified for the combination of an asymmetric organocatalytic aldol reaction and subsequent biocatalytic reduction in aqueous medium, which thus enabled the enantio- and diastereoselective synthesis of 1,3-diols in a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0b41173f80b34139cc345e07efba5f1
https://doi.org/10.1002/ejoc.201600831
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4
Design of recombinant whole-cell catalysts for double reduction of CC and CO bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants
Autor: Harald Gröger, Daniel Bakonyi, Werner Hummel, Marc Biermann
Publikováno v: Green Chemistry. 19:405-410
Whole-cell catalysts overexpressing two enzymes for a double reduction cascade in which aliphatic alpha-branched alpha,beta-unsaturated aldehydes are converted into Guerbet alcohols as a highly demanded class of lubricants were constructed and charac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0dc490f0d22ec41283cbe04dbcb6a36
https://doi.org/10.1039/c6gc01668e
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6
Process Development through Solvent Engineering in the Biocatalytic Synthesis of the Heterocyclic Bulk Chemical ε-Caprolactone
Autor: Anna Reimer, Udo Kragl, Werner Hummel, Harald Gröger, Sandy Schmidt, Svenja Staudt, Severin Wedde, Uwe T. Bornscheuer, Diana Höffer
Publikováno v: Journal of Heterocyclic Chemistry. 54:391-396
For an alternative synthetic approach toward the heterocyclic industrial chemical e-caprolactone, which is based on a biocatalytic oxidation of readily available cyclohexanol with air in aqueous media (using an alcohol dehydrogenase and a Baeyer–Vi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b4b81c1a6558e2d7fd03313a639df94
https://doi.org/10.1002/jhet.2595
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7
Screening, Molecular Cloning, and Biochemical Characterization of an Alcohol Dehydrogenase fromPichia pastorisUseful for the Kinetic Resolution of a Racemic β-Hydroxy-β-trifluoromethyl Ketone
Autor: Werner Hummel, Dalia Bulut, Harald Gröger, Nongnaphat Duangdee, Albrecht Berkessel
Publikováno v: ChemBioChem. 17:1349-1358
The stereoselective synthesis of chiral 1,3-diols with the aid of biocatalysts is an attractive tool in organic chemistry. Besides the reduction of diketones, an alternative approach consists of the stereoselective reduction of beta-hydroxy ketones (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4666fdeea9b89ae28346fb4f328a03dd
https://doi.org/10.1002/cbic.201600101
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8
Integrated Biocatalysis in Multistep Drug Synthesis without Intermediate Isolation: A de Novo Approach toward a Rosuvastatin Key Building Block
Autor: Werner Hummel, Harald Gröger, Burghard König, Richard Metzner, Frank Wetterich
Publikováno v: Organic Process Research & Development. 19:635-638
In this contribution, we report the chemoenzymatic preparation of a key building block for the active pharmaceutical ingredient rosuvastatin, one of the "top 5 blockbuster drugs" with a worldwide market value of 6.25 billion USD in 2012, via a seven-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3811935502eaf19baaf381d46cb66582
https://doi.org/10.1021/acs.oprd.5b00057
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9
Enzyme Module Systems for the Synthesis of Uridine 5′-Diphospho-α-D -glucuronic Acid and Non-Sulfated Human Natural Killer Cell-1 (HNK-1) Epitope
Autor: Leonie Engels, Lothar Elling, Manja Henze, Werner Hummel
Publikováno v: Advanced Synthesis & Catalysis. 357:1751-1762
Tailor-made strategies for the stereo- and regioselective multi-step enzymatic synthesis of glycoconjugates require well characterized glycosyltransferases and carbohydrate modifying enzymes. We here report on a novel enzyme cascade for the synthesis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c97fabf1fb49c0b4f07e0a9faaf2989
https://doi.org/10.1002/adsc.201500180
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10
The Organic-Synthetic Potential of Recombinant Ene Reductases: Substrate-Scope Evaluation and Process Optimization
Autor: Tina Reß, Harald Gröger, Werner Hummel, Hans Iding, Steven P. Hanlon
Publikováno v: ChemCatChem. 7:1302-1311
In this study an evaluation of the synthetic potential of a broad range of recombinant ene reductases was performed. In detail, a library of 23 ene reductases was used to screen the C=C reduction of 21 activated alkenes from different compound classe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e82e17a5cc1b6be40f9f95c949107d
https://doi.org/10.1002/cctc.201402903
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