Recent Advances and Trends in the Brain Delivery of Small Molecule Based Cancer Therapies

Autor: Corine C. Visser, Werner Gladdines, Pieter J. Gaillard, Marco de Boer, Jaap Rip, Arie Reijerkerk, Chantal C.M. Appeldoorn

Current treatment of brain cancer is hampered by few effective treatment options and characterized by low survival rates. Some advanced drug delivery systems carrying small molecules are currently being developed and may have a major positive impact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc91be068369c823052f02e70c8d5df8
https://doi.org/10.1016/b978-0-12-416603-5.00019-5

Glutathione PEGylated liposomal methylprednisolone (2B3-201) attenuates CNS inflammation and degeneration in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis

Autor: Caroline Rötger, Arie Reijerkerk, Chantal C.M. Appeldoorn, Werner Gladdines, Pieter J. Gaillard, De-Hyung Lee, Ralf A. Linker

Publikováno v: Journal of neuroimmunology. 274(1-2)

Methylprednisolone (MP) pulses are the mainstay for relapse therapy in multiple sclerosis (MS). To improve the efficacy of treatment and reduce the side effects of MP, a long circulating brain-targeted formulation was developed; glutathione polyethyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec97d393b6f88698bda4396a829ba17
https://pubmed.ncbi.nlm.nih.gov/25037177

Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA(A) receptor in vivo

Autor: Werner Gladdines, Lambertus A. Peletier, S. A. G. Visser, M. Danhof, P H van der Graaf

Publikováno v: The Journal of pharmacology and experimental therapeutics. 303(2)

The objective of the present investigation was to characterize the in vivo EEG effects of (synthetic) neuroactive steroids on the basis of a recently proposed mechanism-based pharmacokinetic/pharmacodynamic (PK/PD) model. After intravenous administra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569083e4106375a764c56eddce524c4b
https://pubmed.ncbi.nlm.nih.gov/12388643

Abstract CT216: Phase I dose escalating study of 2B3-101, glutathione PEGylated liposomal doxorubicin, in patients with solid tumors and brain metastases or recurrent malignant glioma

Autor: Patricia M. M. B. Soetekouw, Sevilay Altintas, Pieter J. Gaillard, Bojana Milojkovic Kerklaan, Philippe Aftimos, Fredrik Lonnqvist, Werner Gladdines, Ahmad Awada, Agnes Jager, Dieta Brandsma, Jan H.M. Schellens, Henk M.W. Verheul

Publikováno v: Cancer Research. 74:CT216-CT216

Without active delivery across the blood-brain barrier (BBB) the efficacy of doxorubicin in brain tumors is limited. 2B3-101, glutathione PEGylated liposomal doxorubicin, has been developed as brain-targeted chemotherapy. In preclinical studies, 2B3-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4dc9c2da8cc658f6a0185a8710bdfd9
https://doi.org/10.1158/1538-7445.am2014-ct216

High-performance liquid chromatography of the neuroactive steroids alphaxalone and pregnanolone in plasma using dansyl hydrazine as fluuorescent label: application to a pharmacokinetic-pharmacodynamic study in rats

Autor: Meindert Danhof, Werner Gladdines, Hubertus Irth, Piet H. van der Graaf, Chantal J.G.M. Smulders, Sandra A.G. Visser

Publikováno v: Journal of Chromatography B, 745(2), 357-363. Elsevier
Visser, S A G, Smulders, C J G M, Gladdines, W W F T, Irth, H, van der Graaf, P H & Danhof, M 2000, ' High-performance liquid chromatography of the neuroactive steroids alphaxalone and pregnanolone in plasma using dansyl hydrazine as fluuorescent label: application to a pharmacokinetic-pharmacodynamic study in rats ', Journal of Chromatography B, vol. 745, no. 2, pp. 357-363 .
Visser, S J, Smulders, C, Gladdines, W W F T, Irth, H, Graaf, PW & Danhof, M 2000, ' High-performance liquid chromatography of the neuroactive steroids alphaxalone and pregnanolone in plasma using dansyl hydrazine as fluorescent label: application to a pharmacokinetic-pharmacodynamic study in rats ', Journal of Chromatography B, vol. 745, no. 2, pp. 357-63 . https://doi.org/10.1016/S0378-4347(00)00296-6
Journal of Chromatography B, 745(2), 357-63. Elsevier

This report describes a rapid and sensitive analytical method for the quantification of the neuroactive steroids alphaxalone and pregnanolone in rat plasma using derivatization with dansyl hydrazine as fluorescent label. The method involves protein p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3971508235d32599b44be62c468329
https://research.vu.nl/en/publications/6f38f482-55ac-4b69-b696-8dc950cec6a1