The growth hormone–insulin-like growth factor-I axis in the diagnosis and treatment of growth disorders

Autor: Werner F Blum, Abdullah Alherbish, Afaf Alsagheir, Ahmed El Awwa, Walid Kaplan, Ekaterina Koledova, Martin O Savage

Publikováno v: Endocrine Connections, Vol 7, Iss 6, Pp R212-R222 (2018)

The growth hormone (GH)–insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a good knowledge of GH secretion and assessment, understanding and use of measurements of t

Externí odkaz: https://doaj.org/article/76c92ffe12024ec18f7a1c15f179abbe

Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver

Autor: Arne Hinrichs, Barbara Kessler, Mayuko Kurome, Andreas Blutke, Elisabeth Kemter, Maren Bernau, Armin M. Scholz, Birgit Rathkolb, Simone Renner, Sebastian Bultmann, Heinrich Leonhardt, Martin Hrabĕ de Angelis, Hiroshi Nagashima, Andreas Hoeflich, Werner F. Blum, Martin Bidlingmaier, Rüdiger Wanke, Maik Dahlhoff, Eckhard Wolf

Publikováno v: Molecular Metabolism, Vol 11, Iss , Pp 113-128 (2018)

Objective: Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish a large animal model for LS, pigs with GHR knockout (KO) mutations were gene

Externí odkaz: https://doaj.org/article/7c74c35d25ac486abfdbf53fba4fa634

Sex-differences in age-related decline of urinary insulin-like growth factor-binding protein-3 levels in adult bonobos and chimpanzees

Autor: Verena Behringer, Stefan Wudy, Werner F. Blum, Jeroen M. G. Stevens, Thomas Remer, Christophe Boesch, Gottfried Hohmann

Publikováno v: Frontiers in Endocrinology, Vol 7 (2016)

There is increasing interest in the characterization of normative senescence in humans. To assess to what extent aging patterns in humans are unique, comparative data from closely-related species, such as non-human primates, can be very useful. Here

Externí odkaz: https://doaj.org/article/b7a544353e9e41618c6bc0e12bf8c149

Growth, Nutrition and Economy : Proceedings of the 27th Aschauer Soiree, held at Krobielowice, Poland, November 16th 2019

Autor: Andrej Suchomlinov, Sylvia Kirchengast, Raja Chakraborty, Sylwia Bartkowiak, Slawomir Koziel, Robert M. Malina, Lidia Lebedeva, Takashi Satake, Egle Marija Jakimaviciene, Daniel Franken, Christiane Scheffler, Michael Hermanussen, Detlef Groth, Aleksandra Gomula, Jan M. Konarski, James M. Swanson, Ramune Cepuliene, Yehuda Limony, Lidia Martin, Werner F. Blum, Natalia Nowak-Szczepanska, Bárbara Navazo, Vsevolod Konstantinov, Janina Tutkuviene, Anna Apanasewicz, Annang G. Moelyo, James G. Waxmonsky

Publikováno v: Human biology and public health, Potsdam : Potsdam University Library; University Press, 2021, vol. 1, p. 1-13
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

Twenty-three scientists met at Krobielowice, Poland to discuss the role of growth, nutrition and economy on body size. Contrasting prevailing concepts, re-analyses of studies in Indonesian and Guatemalan school children with high prevalence of stunti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2fc4bc70c7cda86aedaf06a2ee5f8d
http://sedici.unlp.edu.ar/handle/10915/143660

Serum IGF1 and linear growth in children with congenital leptin deficiency before and after leptin substitution

Autor: Heike Vollbach, Shlomit Shalitin, Ingrid Körber, Marianna Beghini, Katja Kohlsdorf, Werner F. Blum, Julia von Schnurbein, Belinda Lennerz, Ferruccio Santini, Martin Wabitsch, Christian Denzer, Stephanie Brandt

Publikováno v: International Journal of Obesity (2005)

Background Evidence from in vitro and rodent studies suggests that leptin, a key signal of long-term energy reserves, promotes IGF1 synthesis and linear growth. This effect of leptin has not been fully investigated in humans. The aim of our study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3956f8330824c65d7c393780a70b46f6
http://hdl.handle.net/11568/1115590