Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Werner Dittrich"'
Autor:
Florian Capito, Ting Hin Wong, Christine Faust, Kilian Brand, Werner Dittrich, Mark Sommerfeld, Garima Tiwari, Thomas Langer
Publikováno v:
Engineering in Life Sciences, Vol 24, Iss 9, Pp n/a-n/a (2024)
ABSTRACT While bioactivity and a favorable safety profile for biotherapeutics is of utmost importance, manufacturability is also worth of consideration to ease the manufacturing process. Manufacturability in the scientific literature is mostly relate
Externí odkaz:
https://doaj.org/article/3ab83f18e3f24977baf349050b8be2a9
Publikováno v:
Engineering in Life Sciences, Vol 21, Iss 11, Pp 778-785 (2021)
Abstract The human embryonal kidney 293 cell (HEK‐293) is a widely used expression host for transient gene expression. The genes or plasmids used for the transient transfections are usually propagated and extracted from the gram‐negative bacteriu
Externí odkaz:
https://doaj.org/article/e7d73704dc174b76b633edeb7e530783
Autor:
Norbert Furtmann, Marion Schneider, Nadja Spindler, Bjoern Steinmann, Ziyu Li, Ingo Focken, Joachim Meyer, Dilyana Dimova, Katja Kroll, Wulf Dirk Leuschner, Audrey Debeaumont, Magali Mathieu, Christian Lange, Werner Dittrich, Jochen Kruip, Thorsten Schmidt, Joerg Birkenfeld
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Next-generation multi-specific antibody therapeutics (MSATs) are engineered to combine several functional activities into one molecule to provide higher efficacy compared to conventional, mono-specific antibody therapeutics. However, highly engineere
Externí odkaz:
https://doaj.org/article/98e82558dbcc41848215d30e62e1cd5e
Autor:
Susanne Miehe, Peter Crause, Thorsten Schmidt, Matthias Löhn, Heinz-Werner Kleemann, Thomas Licher, Werner Dittrich, Hartmut Rütten, Carsten Strübing
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35393 (2012)
TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca(2+) signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition h
Externí odkaz:
https://doaj.org/article/a524d3afaf774f058c9b8f1286d01e76
Publikováno v:
Engineering in Life Sciences, Vol 21, Iss 11, Pp 778-785 (2021)
Engineering in Life Sciences
Engineering in Life Sciences
The human embryonal kidney 293 cell (HEK‐293) is a widely used expression host for transient gene expression. The genes or plasmids used for the transient transfections are usually propagated and extracted from the gram‐negative bacterium Escheri
Autor:
Christof Schindler, Christine Faust, Hanno Sjuts, Christian Lange, Jennifer Kühn, Werner Dittrich, Wulf Dirk Leuschner, Werner Schiebler, Joachim Hofmann, Ercole Rao, Thomas Langer
Publikováno v:
Protein Engineering, Design and Selection. 35
The field of therapeutic antibodies and, especially bi- or multispecific antibodies, is growing rapidly. Especially for treating cancers, multispecific antibodies are very promising, as there are multiple pathways involved and multispecific antibodie
Autor:
Audrey Debeaumont, Joachim Meyer, Wulf Dirk Leuschner, Jochen Kruip, Joerg Birkenfeld, Nadja Spindler, Norbert Furtmann, Katja Kroll, Ingo Focken, Bjoern Steinmann, Magali Mathieu, Werner Dittrich, Christian M. Lange, Dilyana Dimova, Ziyu Li, Thorsten Schmidt, M. Schneider
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Next-generation multi-specific antibody therapeutics (MSATs) are engineered to combine several functional activities into one molecule to provide higher efficacy compared to conventional, mono-specific antibody therapeutics. However, highly engineere
Autor:
Oliver Boscheinen, Thomas Langer, Thomas Wendrich, Katja Kroll, Carsten Corvey, Werner Dittrich
Publikováno v:
Preparative Biochemistry & Biotechnology. 47:1008-1015
Glycosylation is one of the most complex post-translational modifications and may have significant influence on the proper function of the corresponding proteins. Bacteria and yeast are, because of easy handling and cost reasons, the most frequently
Autor:
Andrea Brüggemann, Marcel Maier, Werner Dittrich, Johann Gassenhuber, Niels Decher, Klaus Steinmeyer, Andreas E. Busch
Publikováno v:
FEBS Letters. 492:84-89
We report the primary sequence of TASK-4, a novel member of the acid-sensitive subfamily of tandem pore K(+) channels. TASK-4 transcripts are widely expressed in humans, with highest levels in liver, lung, pancreas, placenta, aorta and heart. In Xeno
Autor:
Werner Dittrich, Jan Faix
Publikováno v:
FEBS Letters. 394:251-257
A protein accumulated in the cortical region of Dictyostelium discoideum cells proved to be a homologue of GTPase activating proteins that are responsible for the inactivation of ras in yeast and man. Elimination of this protein, DGAP1, by gene repla