Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Werner Hummel"'
Autor:
Gröger, Daniel Bakonyi, Christine Toelzer, Michael Stricker, Werner Hummel, Karsten Niefind, Harald
Publikováno v:
Catalysts; Volume 10; Issue 11; Pages: 1281
Alcohol dehydrogenases catalyse the conversion of a large variety of ketone substrates to the corresponding chiral products. Due to their high regio- and stereospecificity, they are key components in a wide range of industrial applications. A novel a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::5285e82d46228e0a1d380342b0d71005
Publikováno v:
European Journal of Organic Chemistry. 2017:812-817
A suitable "process window" was identified for the combination of an asymmetric organocatalytic aldol reaction and subsequent biocatalytic reduction in aqueous medium, which thus enabled the enantio- and diastereoselective synthesis of 1,3-diols in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0b41173f80b34139cc345e07efba5f1
https://doi.org/10.1002/ejoc.201600831
https://doi.org/10.1002/ejoc.201600831
Publikováno v:
Green Chemistry. 19:405-410
Whole-cell catalysts overexpressing two enzymes for a double reduction cascade in which aliphatic alpha-branched alpha,beta-unsaturated aldehydes are converted into Guerbet alcohols as a highly demanded class of lubricants were constructed and charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0dc490f0d22ec41283cbe04dbcb6a36
https://doi.org/10.1039/c6gc01668e
https://doi.org/10.1039/c6gc01668e
Autor:
Anna Reimer, Udo Kragl, Werner Hummel, Harald Gröger, Sandy Schmidt, Svenja Staudt, Severin Wedde, Uwe T. Bornscheuer, Diana Höffer
Publikováno v:
Journal of Heterocyclic Chemistry. 54:391-396
For an alternative synthetic approach toward the heterocyclic industrial chemical e-caprolactone, which is based on a biocatalytic oxidation of readily available cyclohexanol with air in aqueous media (using an alcohol dehydrogenase and a Baeyer–Vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b4b81c1a6558e2d7fd03313a639df94
https://doi.org/10.1002/jhet.2595
https://doi.org/10.1002/jhet.2595
Publikováno v:
ChemBioChem. 17:1349-1358
The stereoselective synthesis of chiral 1,3-diols with the aid of biocatalysts is an attractive tool in organic chemistry. Besides the reduction of diketones, an alternative approach consists of the stereoselective reduction of beta-hydroxy ketones (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4666fdeea9b89ae28346fb4f328a03dd
https://doi.org/10.1002/cbic.201600101
https://doi.org/10.1002/cbic.201600101
Publikováno v:
ChemCatChem. 8:895-899
A novel synthetic approach towards Guerbet alcohols, which are important intermediates in the production of plasticizers, lubricants, and surfactants, was developed. In contrast to the harsh reaction conditions of Guerbet alcohols produced today, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09486f02629cf2c277a9f0a67a95301
https://doi.org/10.1002/cctc.201501241
https://doi.org/10.1002/cctc.201501241
Publikováno v:
Organic Process Research & Development. 19:635-638
In this contribution, we report the chemoenzymatic preparation of a key building block for the active pharmaceutical ingredient rosuvastatin, one of the "top 5 blockbuster drugs" with a worldwide market value of 6.25 billion USD in 2012, via a seven-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3811935502eaf19baaf381d46cb66582
https://doi.org/10.1021/acs.oprd.5b00057
https://doi.org/10.1021/acs.oprd.5b00057
Publikováno v:
Advanced Synthesis & Catalysis. 357:1751-1762
Tailor-made strategies for the stereo- and regioselective multi-step enzymatic synthesis of glycoconjugates require well characterized glycosyltransferases and carbohydrate modifying enzymes. We here report on a novel enzyme cascade for the synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c97fabf1fb49c0b4f07e0a9faaf2989
https://doi.org/10.1002/adsc.201500180
https://doi.org/10.1002/adsc.201500180
Publikováno v:
ChemCatChem. 7:1302-1311
In this study an evaluation of the synthetic potential of a broad range of recombinant ene reductases was performed. In detail, a library of 23 ene reductases was used to screen the C=C reduction of 21 activated alkenes from different compound classe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e82e17a5cc1b6be40f9f95c949107d
https://doi.org/10.1002/cctc.201402903
https://doi.org/10.1002/cctc.201402903
Publikováno v:
Angewandte Chemie International Edition. 54:4488-4492
A Wacker oxidation using CuCl/PdCl2 as a catalyst system was successfully combined with an enzymatic ketone reduction to convert styrene enantioselectively into 1-phenylethanol in a one-pot process, although the two reactions conducted in aqueous med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec6ebd30ce8b9586aa03a898b15c0fd
https://doi.org/10.1002/anie.201409590
https://doi.org/10.1002/anie.201409590