Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Werner, Rubas"'
Autor:
William L Redmond, Annah S Rolig, Daniel C Rose, Saul Kivimae, Werner Rubas, Grace Helen McGee
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 4 (2022)
Externí odkaz:
https://doaj.org/article/4660056a8ddb4319b639349b8a49a853
Autor:
Peter Kirk, Murali Addepalli, Thomas Chang, Palakshi Obalapur, Peiwen Kuo, Phi Quach, Jonathan Zalevsky, Rhoneil Pena, Saul Kivimae, Werner Rubas, Takahiro Miyazaki, Loui Madakamutil, Mekhala Maiti, Marlene Hennessy, Sara Sheibani, Joanna Wilczek, Janet Cetz, Andrew Moffett, Yinyan Tang, Jicai Huang, Dawei Sheng
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Background NKTR-255 is a novel polyethylene glycol-conjugate of recombinant human interleukin-15 (rhIL-15), which was designed to retain all known receptor binding interactions of the IL-15 molecule. We explored the biologic and pharmacologic differe
Externí odkaz:
https://doaj.org/article/e08faa8782fa46a5a98602da0126f298
Autor:
Neha Dixit, Christie Fanton, John L. Langowski, Yolanda Kirksey, Peter Kirk, Thomas Chang, Janet Cetz, Vidula Dixit, Grace Kim, Peiwen Kuo, Mekhala Maiti, Yinyan Tang, Laurie A. VanderVeen, Ping Zhang, Myong Lee, Jerome Ritz, Yusuke Kamihara, Chunmei Ji, Werner Rubas, Theresa D. Sweeney, Stephen K. Doberstein, Jonathan Zalevsky
Publikováno v:
Journal of Translational Autoimmunity, Vol 4, Iss , Pp 100103- (2021)
Impaired interleukin-2 (IL-2) production and regulatory T-cell dysfunction have been implicated as immunological mechanisms central to the pathogenesis of multiple autoimmune and inflammatory diseases. NKTR-358, a novel regulatory T-cell stimulator,
Externí odkaz:
https://doaj.org/article/63812ff90adf4c7e9449ec1fa8aa92e5
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/b275981c0c2c41e08b799180ddc9f95e
Autor:
Alice Yam, Jeff Hanson, Krishna Bajjuri, Sihong Zhou, Dayson Moreira, Jennifer Smith, Cristina Abrahams, Xiaofan Li, Grace Lee, Stephanie Armstrong, Amandeep Gakhal, Daniel Calarese, Young Park, Miao Wen, Gang Yin, Simon Chivers, Faye Hsieh, Guifen Xu, Werner Rubas, Andreas Maderna, Kristin Bedard, Trevor Hallam
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f00189b277e2d396c7af563054d7632
https://doi.org/10.1136/jitc-2022-sitc2022.1191
https://doi.org/10.1136/jitc-2022-sitc2022.1191
Autor:
Deborah Charych, Samira Khalili, Vidula Dixit, Peter Kirk, Thomas Chang, John Langowski, Werner Rubas, Stephen K Doberstein, Michael Eldon, Ute Hoch, Jonathan Zalevsky
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0179431 (2017)
Cytokines are potent immune modulating agents but are not ideal medicines in their natural form due to their short half-life and pleiotropic systemic effects. NKTR-214 is a clinical-stage biologic that comprises interleukin-2 (IL2) protein bound by m
Externí odkaz:
https://doaj.org/article/1b2e6798a2dc4534affc499f2f703980
Autor:
Annah S, Rolig, Daniel C, Rose, Grace Helen, McGee, Werner, Rubas, Saul, Kivimäe, William L, Redmond
Publikováno v:
Journal for immunotherapy of cancer. 10(4)
Tumor cell death caused by radiation therapy (RT) triggers antitumor immunity in part because dying cells release adjuvant factors that amplify and sustain dendritic cell and T cell responses. We previously demonstrated that bempegaldesleukin (BEMPEG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13e417440116e6ee21c9ad5e07b8e4e9
https://pubmed.ncbi.nlm.nih.gov/35444059
https://pubmed.ncbi.nlm.nih.gov/35444059
Autor:
Jerome Ritz, Peiwen Kuo, Yolanda Kirksey, Vidula Dixit, Yusuke Kamihara, Jonathan Zalevsky, Myong Lee, Yinyan Tang, Theresa D. Sweeney, Stephen Doberstein, Grace Kim, Thomas Chang, Kirk Peter Benedict, Neha Dixit, Laurie VanderVeen, Ping Zhang, Christie Fanton, Mekhala Maiti, John L. Langowski, Werner Rubas, Chunmei Ji, Janet Cetz
Publikováno v:
Journal of Translational Autoimmunity, Vol 4, Iss, Pp 100103-(2021)
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity
Impaired interleukin-2 (IL-2) production and regulatory T-cell dysfunction have been implicated as immunological mechanisms central to the pathogenesis of multiple autoimmune and inflammatory diseases. NKTR-358, a novel regulatory T-cell stimulator,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e4db55294c2e6243a6643779f5c173
http://www.sciencedirect.com/science/article/pii/S258990902100023X
http://www.sciencedirect.com/science/article/pii/S258990902100023X
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Previously, we demonstrated that radiation therapy (RT) combined with Bempegaldesleukin (BEMPEG;NKTR-214), a first-in-class CD122-preferential IL-2 pathway agonist, led to enhanced anti-tumor efficacy through a T cell-dependent mechanism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3365cf971afcb66e834dde992f33cf
https://doi.org/10.1136/jitc-2020-sitc2020.0451
https://doi.org/10.1136/jitc-2020-sitc2020.0451
Autor:
Daniel Rose, Grace Helen McGee, Saul Kivimae, Annah S Rolig, William L. Redmond, Werner Rubas
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A626-A626
BackgroundTumor cell death caused by radiation therapy (RT) can trigger anti-tumor immune responses in part because dying cells release adjuvant factors that amplify and sustain DC and T cell responses. We previously demonstrated that bempegaldesleuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2719e4e702a48dbe1c47c581d018300d
https://doi.org/10.1136/jitc-2021-sitc2021.596
https://doi.org/10.1136/jitc-2021-sitc2021.596