Zobrazeno 1 - 10
of 461
pro vyhledávání: '"Wermeling P"'
Autor:
Majid Pahlevan Kakhki, Antonino Giordano, Chiara Starvaggi Cucuzza, Tejaswi Venkata S. Badam, Samudyata Samudyata, Marianne Victoria Lemée, Pernilla Stridh, Asimenia Gkogka, Klementy Shchetynsky, Adil Harroud, Alexandra Gyllenberg, Yun Liu, Sanjaykumar Boddul, Tojo James, Melissa Sorosina, Massimo Filippi, Federica Esposito, Fredrik Wermeling, Mika Gustafsson, Patrizia Casaccia, Jan Hillert, Tomas Olsson, Ingrid Kockum, Carl M. Sellgren, Christelle Golzio, Lara Kular, Maja Jagodic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Multiple Sclerosis (MS) is a heterogeneous inflammatory and neurodegenerative disease with an unpredictable course towards progressive disability. Treating progressive MS is challenging due to limited insights into the underlying mechanisms.
Externí odkaz:
https://doaj.org/article/335891136a424c99812fda12c3ca1d91
Autor:
Ahlem Zaghmi, Erdem Aybay, Long Jiang, Mingmei Shang, Julia Steinmetz‐Späh, Fredrik Wermeling, Per Kogner, Marina Korotkova, Päivi Östling, Per‐Johan Jakobsson, Brinton Seashore‐Ludlow, Karin Larsson
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 317-335 (2024)
High‐throughput drug screening enables the discovery of new anticancer drugs. Although monolayer cell cultures are commonly used for screening, their limited complexity and translational efficiency require alternative models. Three‐dimensional ce
Externí odkaz:
https://doaj.org/article/4a29d39e06f844be8b5afb223e6cda70
Autor:
Katrine Ingelshed, Marit M. Melssen, Pavitra Kannan, Arun Chandramohan, Anthony W. Partridge, Long Jiang, Fredrik Wermeling, David P. Lane, Marika Nestor, Diana Spiegelberg
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109862- (2024)
Summary: Immunotherapy has revolutionized cancer treatment but its efficacy depends on a robust immune response in the tumor. Silencing of the tumor suppressor p53 is common in tumors and can affect the recruitment and activation of different immune
Externí odkaz:
https://doaj.org/article/a6f5c387d3ed4365a35bb503c9592eba
Autor:
Farinotti, Alex Bersellini, Wigerblad, Gustaf, Nascimento, Diana, Bas, Duygu B, Urbina, Carlos Morado, Nandakumar, Kutty Selva, Sandor, Katalin, Xu, Bingze, Abdelmoaty, Sally, Hunt, Matthew A, Möller, Kristina Ängeby, Baharpoor, Azar, Sinclair, Jon, Jardemark, Kent, Lanner, Johanna T, Khmaladze, Ia, Borm, Lars E., Zhang, Lu, Wermeling, Fredrik, Cragg, Mark S, Lengqvist, Johan, Chabot-Doré, Anne-Julie, Diatchenko, Luda, Belfer, Inna, Collin, Mattias, Kultima, Kim, Heyman, Birgitta, Jimenez-Andrade, Juan M., Codeluppi, Simone, Holmdahl, Rikard, Svensson, Camilla I
Publikováno v:
Journal of Experimental Medicine Aug 2019, 216 (8) 1904-1924
Rheumatoid arthritis-associated joint pain is frequently observed independent of disease activity, suggesting unidentified pain mechanisms. We demonstrate that antibodies binding to cartilage, specific for collagen type II (CII) or cartilage oligomer
Externí odkaz:
http://arxiv.org/abs/1908.05298
Autor:
Ada Lerma Clavero, Paula Lafqvist Boqvist, Katrine Ingelshed, Cecilia Bosdotter, Saikiran Sedimbi, Long Jiang, Fredrik Wermeling, Borivoj Vojtesek, David P. Lane, Pavitra Kannan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Activation of p53 by small molecule MDM2 inhibitors can induce cell cycle arrest or death in p53 wildtype cancer cells. However, cancer cells exposed to hypoxia can develop resistance to other small molecules, such as chemotherapies, that ac
Externí odkaz:
https://doaj.org/article/d3a15f50009a4aceacfbb783e8945359
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Ravi K. Sharma, Sanjay V. Boddul, Niyaz Yoosuf, Sara Turcinov, Anatoly Dubnovitsky, Genadiy Kozhukh, Fredrik Wermeling, William W. Kwok, Lars Klareskog, Vivianne Malmström
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract We aimed to search for common features in the autoreactive T cell receptor (TCR) repertoire in patients with rheumatoid arthritis (RA), focusing on the newly identified candidate antigen citrullinated Tenascin C (cit-TNC). Mononuclear cells
Externí odkaz:
https://doaj.org/article/14d145fadcf44f8dbefb370495f5fe23
Autor:
Julia Steinmetz-Späh, Jianyang Liu, Rajkumar Singh, Maria Ekoff, Sanjaykumar Boddul, Xiao Tang, Filip Bergqvist, Helena Idborg, Pascal Heitel, Elin Rönnberg, Daniel Merk, Fredrik Wermeling, Jesper Z. Haeggström, Gunnar Nilsson, Dieter Steinhilber, Karin Larsson, Marina Korotkova, Per-Johan Jakobsson
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 12, Pp 100310- (2022)
Inhibition of microsomal prostaglandin E synthase-1 (mPGES-1) results in decreased production of proinflammatory PGE2 and can lead to shunting of PGH2 into the prostaglandin D2 (PGD2)/15-deoxy-Δ12,14-prostaglandin J2 (15dPGJ2) pathway. 15dPGJ2 forms
Externí odkaz:
https://doaj.org/article/21de76dd4fea476cb4a8cc5faaeadde7