Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Weonjin Yu"'
Autor:
Ann-Na Cho, Yoonhee Jin, Yeonjoo An, Jin Kim, Yi Sun Choi, Jung Seung Lee, Junghoon Kim, Won-Young Choi, Dong-Jun Koo, Weonjin Yu, Gyeong-Eon Chang, Dong-Yoon Kim, Sung-Hyun Jo, Jihun Kim, Sung-Yon Kim, Yun-Gon Kim, Ju Young Kim, Nakwon Choi, Eunji Cheong, Young-Joon Kim, Hyunsoo Shawn Je, Hoon-Chul Kang, Seung-Woo Cho
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular m
Externí odkaz:
https://doaj.org/article/4baaa6ea520348a5bdc13ee2f2a1412c
Autor:
Weonjin Yu, Yi-Chun Yen, Young-Hwan Lee, Shawn Tan, Yixin Xiao, Hidayat Lokman, Audrey Khoo Tze Ting, Hasini Ganegala, Taejoon Kwon, Won-Kyung Ho, H. Shawn Je
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-13 (2019)
Abstract Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed antidepressant drugs in pregnant women. Infants born following prenatal exposure to SSRIs have a higher risk for behavioral abnormalities, however, the underlying mechan
Externí odkaz:
https://doaj.org/article/1e08fa7383584109bbbe2f4acd3ba97d
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-10 (2018)
Abstract Timing and temporal precision of action potential generation are thought to be important for encoding of information in the brain. The ability of single neurons to transform their input into output action potential is primarily determined by
Externí odkaz:
https://doaj.org/article/310b2dccc9384aaab3cc881b66f63fac
Autor:
Kujin Kwon, Hwapyeong Cho, Soyeon Lee, Eun Jeong Cho, Weonjin Yu, Catherine Yen Li Kok, Hyunsoo Shawn Je, Jae‐Ick Kim, Hyung Joon Cho, Taejoon Kwon
Publikováno v:
Aging Cell. 21
Progressive iron accumulation in the substantia nigra in the aged human brain is a major risk factor for Parkinson's disease and other neurodegenerative diseases. Heavy metals, such as iron, produce reactive oxygen species and consequently oxidative
Autor:
Mui Hoon Nai, Hoang-Dai Tran, Huck-Hui Ng, Chwee Teck Lim, Kah-Leong Lim, Haidun Yan, Koji Itahana, Menglan Zhang, Stephanie Wai Lin Lim, Qiang Yuan, Yoko Itahana, Giuseppe D'Agostino, Yong-hui Jiang, Alfred Xuyang Sun, Eng-King Tan, Danlei Wang, Hidayat Lokman, Owen J. L. Rackham, Weonjin Yu, Stuart A. Cook, Grace Lim, Ya Yin Chang, Masahiro Fukuda, Hyunsoo Shawn Je, Jiong Tang
Publikováno v:
Science. 366:1486-1492
Hyperexcitable neurons in brain organoids Individuals with Angelman syndrome experience intellectual disability and seizures throughout their lives. In this condition, ubiquitin-mediated degradation of a key potassium channel is disrupted, allowing f
Autor:
Jung Seung Lee, Yun-Gon Kim, Hoon Chul Kang, Ji Hun Kim, Ann Na Cho, Dong-Jun Koo, Jin Kim, Yi Sun Choi, Ju-Young Kim, Yoonhee Jin, Weonjin Yu, Sung-Hyun Jo, Gyeong-Eon Chang, Nakwon Choi, Won-Young Choi, Sung-Yon Kim, Seung Woo Cho, Dongyoon Kim, Eunji Cheong, Jung-Hoon Kim, Yeonjoo An, Hyunsoo Shawn Je, Young Joon Kim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
Nature Communications
Nature Communications
Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro model to recapitulate human brain development and neurological diseases. However, the current systems for brain organoid culture require further improvement
Autor:
Weonjin Yu1,2 (AUTHOR), Jong-Woo Sohn1,3 (AUTHOR), Jaehan Kwon1,2 (AUTHOR), Suk-Ho Lee1,2 (AUTHOR), Sooyun Kim1,2 (AUTHOR) sooyun.kim@snu.ac.kr, Won-Kyung Ho1,2 (AUTHOR) wonkyung@snu.ac.kr
Publikováno v:
Molecular Brain. 11/9/2018, Vol. 11 Issue 1, p1-10. 10p. 5 Graphs.
Autor:
Hidayat Lokman, Huck-Hui Ng, Audrey Tze Ting Khoo, Wei-Yi Ong, Junghyun Jo, Grace Lim, Hoang Dai Tran, Seung-Jae Lee, Weonjin Yu, Lin Yang, Lai Ping Yaw, Ya Yin Chang, Jessica Jiaxin Xie, Kah-Leong Lim, Bin Xiao, Eng-King Tan, Tzuen Yih Saw, Byung Chul Jung, Alfred Xuyang Sun, Hyunsoo Shawn Je
Publikováno v:
Annals of neurology. 90(3)
Objective: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parki
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-10 (2018)
Timing and temporal precision of action potential generation are thought to be important for encoding of information in the brain. The ability of single neurons to transform their input into output action potential is primarily determined by intrinsi
Publikováno v:
The Journal of Physiology. 596:4141-4156
Key points High-frequency stimulation (HFS) of the Schaffer collateral pathway activates metabotropic glutamate receptor 5 (mGluR5) signalling in the proximal apical dendrites of CA1 pyramidal neurons. The synaptic activation of mGluR5-mediated calci