Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Weon Sup Lee"'
Autor:
Eunhyeong Lee, Eun-Ah Lee, Eunji Kong, Haemin Chon, Melissa Llaiqui-Condori, Cheon Ho Park, Beom Yong Park, Nu Ri Kang, Jin-San Yoo, Hyun-Soo Lee, Hyung-Seok Kim, Sung-Hong Park, Seung-Won Choi, Dietmar Vestweber, Jeong Ho Lee, Pilhan Kim, Weon Sup Lee, Injune Kim
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 2, Pp 470-484 (2023)
Brain tumours: antibody blocks blood vessel abnormality An antibody targeting key signalling pathways could prevent brain tumor vessels from being abnormal, thereby improving drug delivery into tumor tissues. Glioblastoma multiforme is considered one
Externí odkaz:
https://doaj.org/article/7679f0e3c99440579fb6c60a6fb0e645
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e78115950aed997ce869a1acd1104c45
https://doi.org/10.1136/jitc-2022-sitc2022.0751
https://doi.org/10.1136/jitc-2022-sitc2022.0751
Agonistic Tie2 antibody suppresses normal-to-tumor vascular transition in glioblastoma invading zone
Autor:
Injune Kim, Eunhyeong Lee, Eun-Ah Lee, Eunji Kong, Haemin Chon, Cheon Ho Park, Beom Yong Park, Nuri Kang, Jin-San Yoo, Hyun-Soo Lee, Hyung Seok Kim, Sung-Hong Park, seung won choi, Dietmar Vestweber, Jeong Ho Lee, Pilhan Kim, Weon Sup Lee
Tumor progression is intimately associated with the vasculature, as tumor proliferation induces angiogenesis and tumor cells metastasize to distant organs via blood vessels. However, whether tumor invasion is associated with blood vessels remains unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15f4356dccf49f0bafe38244a8087ed7
https://doi.org/10.21203/rs.3.rs-1903833/v1
https://doi.org/10.21203/rs.3.rs-1903833/v1
Autor:
Kate Wilkinson, Sally Jackson, Nicola Jones, Weon Sup Lee, Jin-San Yoo, Eugene Moylan, Tamiem Adam, Jeannette Devoto, Seon Young Lee, Silvie Radmil, Aflah Roohullah, Arlene Chan
Publikováno v:
Cancer Research. 81:PS10-18
Background: Metastatic TNBC (mTNBC) has a poor prognosis. Preclinical data suggests benefit for combination therapy of immune checkpoint inhibitor and anti-angiogenesis. Olinvacimab (O) is a fully humanised monoclonal antibody (MAB) which binds to Va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abd2397a2dc320bac37b1fdb450070f1
https://doi.org/10.1158/1538-7445.sabcs20-ps10-18
https://doi.org/10.1158/1538-7445.sabcs20-ps10-18
Autor:
Adithya Balasubramanian, George Iatropoulos, Samantha Bowyer, Hui Kong Gan, Anne P Long, Michael Bynevelt, Graeme Jackson, Seon Young Lee, Weon Sup Lee, Jinsan Yoo, Anna Nowak, Lawrence Cher
Introduction The VEGF pathway remains an important target in GBM given its vascularity and autocrine VEGF signalling. Olinvacimab is a fully humanised VEGFR2 monoclonal antibody that binds and inhibits the receptor. This report assesses the safety, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::172ce5fb1cba640a00545a825f6dc014
https://doi.org/10.21203/rs.3.rs-1668912/v1
https://doi.org/10.21203/rs.3.rs-1668912/v1
Autor:
Jin-San Yoo, Kyoung-Seok Ryu, Jong Geun Jeong, Soyoung Cha, Joonhyeok Choi, Joon-Hwa Lee, Jihong Kim, Ju Ryoung Nam, Hak-Nam Kim, Weon Sup Lee
Publikováno v:
Journal of Biomolecular NMR. 74:311-319
Monoclonal antibody (mAb) drugs are clinically important for the treatment of various diseases. TTAC-0001 is under development as a new anti-cancer antibody drug targeting VEGFR-2. As the less severe toxicity of TTAC-0001 compared to Bevacizumab, lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdecc841f3662e88072a9bcada5976c2
https://doi.org/10.1007/s10858-020-00313-1
https://doi.org/10.1007/s10858-020-00313-1
Publikováno v:
Cancer Research. 82:5557-5557
Purpose: We investigated the pharmacology of PMC-309 in ex vivo or in vivo characterization for the development of the preclinical study. Experimental procedures: Target selectivity: it was measured by SPR assay. Human VISTA expressing CHO k1 cells o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0ab35555593f858207063dfac21947b
https://doi.org/10.1158/1538-7445.am2022-5557
https://doi.org/10.1158/1538-7445.am2022-5557
Publikováno v:
Cancer Research. 82:5970-5970
Purpose: The delivery of drugs and immune cells into the tumor microenvironment is limited due to abnormal tumor vessel which is characterized as low oxygen concentration, low perfusion rate and leakage. It leads to diminish the efficacy radiation th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a848a6b75c5910212007a1d78c0eccf5
https://doi.org/10.1158/1538-7445.am2022-5970
https://doi.org/10.1158/1538-7445.am2022-5970
Autor:
Anne Poh Long, Anna K. Nowak, Samantha Bowyer, Weon Sup Lee, Lawrence Cher, Hui K Gan, Seon Young Lee, Michael Bynevelt, Jin-San Yoo, Graeme Jackson, George Iatropoulos
Publikováno v:
Neuro Oncol
The VEGF pathway remains an important target in GBM given its vascularity and autocrine VEGF signalling. Olinvacimab (TTAC-0001) is a fully humanised VEGFR2 Mab that binds and inhibits the receptor. This report assesses the safety, dosing schedules a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eac6579e97bf59e7121684c70dd0a86
https://europepmc.org/articles/PMC7650443/
https://europepmc.org/articles/PMC7650443/
Autor:
Sun Hyung Ha, Beom Yong Park, Jin-San Yoo, Nu Ri Kang, Hyun Sun Park, Jin Yong An, Cheon Ho Park, Byun Sang Soon, Hye Rim Han, Eun-Ah Lee, Weon Sup Lee
Publikováno v:
Cancer Research. 81:1626-1626
TME (tumor microenvironment) consists of blood & lymphatic vessels, stromal cells, and immune cells such as lymphocytes, macrophages, and antigen-presenting cells (APC). Cellular interactions among various immune cell types within TME regulate tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85a5abfae981c275f2577c27b713b8a5
https://doi.org/10.1158/1538-7445.am2021-1626
https://doi.org/10.1158/1538-7445.am2021-1626