Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Wenzhi Tian"'
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Since its initial report in 2015, CD47 has garnered significant attention as an innate immune checkpoint, raising expectations to become the next “PD-1.” The optimistic early stages of clinical development spurred a flurry of licensing deals for
Externí odkaz:
https://doaj.org/article/91533ade9e96474d99be910d47b3e243
Autor:
Song Li, Dianze Chen, Yanan Yang, Huiqin Guo, Dandan Liu, Nana Sun, Xing Bai, Kaili Wang, Tengfei Li, Guanghui Li, Chunmei Yang, Wei Zhang, Li Zhang, Gui Zhao, Liang Peng, Sijin Liu, Xiaoping Tu, Ruliang Zhang, Wenzhi Tian
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundCD38 and CD47 are expressed in many hematologic malignancies, including multiple myeloma (MM), B-cell non-Hodgkin lymphoma (NHL), B-cell acute lymphoblastic leukemia (ALL), and B-cell chronic lymphocytic leukemia (CLL). Here, we evaluated t
Externí odkaz:
https://doaj.org/article/2b6d7593a71944e185704f99173a0bbe
Publikováno v:
Materials Today Bio, Vol 26, Iss , Pp 101043- (2024)
Extensive research has delved into the multifaceted roles of osteoclasts beyond their traditional function in bone resorption in recent years, uncovering their significant influence on bone formation. This shift in understanding has spurred investiga
Externí odkaz:
https://doaj.org/article/acf6ed4d6f074e14a48f5ac8a111f121
Autor:
Song Li, Dianze Chen, Huiqin Guo, Dandan Liu, Chunmei Yang, Ruliang Zhang, Tianxiang Wang, Fan Zhang, Xing Bai, Yanan Yang, Nana Sun, Wei Zhang, Li Zhang, Gui Zhao, Liang Peng, Xiaoping Tu, Wenzhi Tian
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundA significant level of CD70 can be detected in various types of tumor tissues and CD27 is expressed on Treg cells, but CD70 expression is low in normal tissues. The interaction between CD70 and CD27 can stimulate the proliferation and survi
Externí odkaz:
https://doaj.org/article/2a637a2d211c4adcb0135076923d7b75
Autor:
Jifeng Yu, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Wei Zhang, Li Zhang, Gui Zhao, Xiaoping Tu, Liang Peng, Sijin Liu, Xing Bai, Yongping Song, Zhongxing Jiang, Ruliang Zhang, Wenzhi Tian
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-4 (2022)
Abstract A novel recombinant SIRPα-Fc fusion protein, IMM01, was constructed and produced using an in-house developed CHO-K1 cell expression system, and the anti-tumor mechanism of IMM01 targeting the CD47-SIRPα pathway was explored. The phagocytos
Externí odkaz:
https://doaj.org/article/3bac8310afe24019a754309f5e7597e8
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-18 (2021)
Abstract Much progress has been made in targeting CD47 for cancer immunotherapy in solid tumors (ST) and hematological malignancies. We summarized the CD47-related clinical research and analyzed the research trend both in the USA and in China. As of
Externí odkaz:
https://doaj.org/article/880f83cfc5a145cfaa6259099a396210
Autor:
Maohua Li, Rongqing Zhao, Jianxin Chen, Wenzhi Tian, Chenxi Xia, Xudong Liu, Yingzi Li, Song Li, Hunter Sun, Tong Shen, Wenlin Ren, Le Sun
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract FDA-approved anti-PD-L1 antibody drug Atezolizumab is a human IgG1 without glycosylation by an N297A mutation. Aglycosylation of IgG1 has been used to completely remove the unwanted Fc-mediated functions such as antibody-dependent cytotoxici
Externí odkaz:
https://doaj.org/article/dc40c43a4c1549208b032432432a8633
Autor:
Jiayang Liu, Zhefeng Meng, Tongyang Xu, Kudelaidi Kuerban, Songna Wang, Xuyao Zhang, Jiajun Fan, Dianwen Ju, Wenzhi Tian, Xuan Huang, Xiting Huang, Danjie Pan, Huaning Chen, Weili Zhao, Li Ye
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The SIRPαFc fusion protein can block the immunosuppressive CD47-SIRPα signal between macrophages and tumor cells as a decoy receptor and has demonstrated its immunotherapeutic efficacy in various tumors. However, its clinical application was limite
Externí odkaz:
https://doaj.org/article/3aa1b4c5a55f4160afe22c5e1bd086b9
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-10 (2020)
Abstract The intact antibody of human immunoglobulin (IgG) is composed of the fragment for antigen binding (Fab) and the crystallizable fragment (Fc) for binding of Fcγ receptors. Among the four subclasses of human IgG (IgG1, IgG2, IgG3, IgG4), whic
Externí odkaz:
https://doaj.org/article/701307dbf636423199264ff9df38a754
Autor:
Xuyao Zhang, Yichen Wang, Jiajun Fan, Wei Chen, Jingyun Luan, Xiaobin Mei, Shaofei Wang, Yubin Li, Li Ye, Song Li, Wenzhi Tian, Kai Yin, Dianwen Ju
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract Background Inhibitors targeting VEGF and VEGFR are commonly used in the clinic, but only a subset of patients could benefit from these inhibitors and the efficacy was limited by multiple relapse mechanisms. In this work, we aimed to investig
Externí odkaz:
https://doaj.org/article/ce87a851c9474d56ac93ac2110d12aaf