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pro vyhledávání: '"Wenzhi Gai"'
Autor:
Wenzhi Gai, Sergio Corral, Jonathan S. Rosenblum, Kevin R. Shreder, Douglas K. Ferris, Yongsheng Liu
Publikováno v:
Chemistry & Biology. 12:99-107
SummaryPolo-like kinases (PLKs) play critical roles throughout mitosis. Here, we report that wortmannin, which was previously thought to be a highly selective inhibitor of phosphoinositide (PI) 3-kinases, is a potent inhibitor of mammalian PLK1. Obse