Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Wenying Piao"'
Autor:
Tomoko Nishina, Junna Numata, Kazutaka Nishina, Kie Yoshida-Tanaka, Keiko Nitta, Wenying Piao, Rintaro Iwata, Shingo Ito, Hiroya Kuwahara, Takeshi Wada, Hidehiro Mizusawa, Takanori Yokota
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
We developed an efficient system for delivering short interfering RNA (siRNA) to the liver by using α-tocopherol conjugation. The α-tocopherol–conjugated siRNA was effective and safe for RNA interference–mediated gene silencing in vivo. In cont
Externí odkaz:
https://doaj.org/article/720afe85465748c58e97aac4309e7d69
Autor:
Huijia Guo, Kazutaka Nishina, Rintaro Iwata Hara, Wenying Piao, Takanori Yokota, Kie Yoshida-Tanaka, Taiki Kunieda, Satoshi Obika, Takeshi Wada, Kotaro Yoshioka, Haruka Miyata, Tetsuya Nagata, Yumiko Sujino, Hiroya Kuwahara, Yutaro Asami
Publikováno v:
Nucleic Acids Research
AntimiR is an antisense oligonucleotide that has been developed to silence microRNA (miRNA) for the treatment of intractable diseases. Enhancement of its in vivo efficacy and improvement of its toxicity are highly desirable but remain challenging. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63779beb3b177aacfba47d66ad0c9d62
http://europepmc.org/articles/PMC6698647
http://europepmc.org/articles/PMC6698647
Autor:
Pek-Lan Khong, Lin Jia, Anne Wing Mui Lee, Lydia W.T. Cheung, Vivian Wai Yan Lui, Zhichao Xue, Kwok Wai Lo, Victor Ho Fan Lee, Hui Yuan, Xin Li, Sai Wah Tsao, Chanping You, Wenying Piao, Chi Man Tsang, Yongshu Li
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Recent genomic analyses revealed that druggable molecule targets were only detectable in approximately 6% of patients with nasopharyngeal carcinoma (NPC). However, a dependency on dysregulated CDK4/6–cyclinD1 pathway signaling is an esse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b83cd74b3a164556fb21c217d93ac21
https://doi.org/10.21203/rs.3.rs-36929/v2
https://doi.org/10.21203/rs.3.rs-36929/v2
Autor:
Jessie Sze Wing Tse, Wenying Piao, Sharon Suet Man Chan, Yuchen Liu, Alexandria Lau, Vivian Wai Yan Lui, Hui Li, Chin Wang Lau, Hoi Lam Ngan, Jason Y. K. Chan, Yu-xiong Su, Andrew Yuon Fong, Peony Hiu Yan Poon, Kwok Wai Lo, Jennifer R. Grandis, Chun Kit Yeung, Gordon B. Mills, Sze Man Chan
Publikováno v:
Life science alliance, vol 3, iss 6
Life Science Alliance
Life Science Alliance
MAPK mutations favor HNSCC survival, revealing the broad clinical utility of MAPK pathway mutations in prognosis and potentially in precision immunotherapy.
MAPK pathway mutations affect one-fifth of head and neck squamous cell carcinoma (HNSCC)
MAPK pathway mutations affect one-fifth of head and neck squamous cell carcinoma (HNSCC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87751b7eea02b245459c14acc200e62f
https://escholarship.org/uc/item/0gd0s96r
https://escholarship.org/uc/item/0gd0s96r
Autor:
Zhichao Xue, Lui, Vivian Wai Yan, Yongshu Li, Jia, Lin, Chanping You, Li, Xin, Wenying Piao, Yuan, Hui, Pek Lan Khong, Kwok Wai Lo, Cheung, Lydia Wai Ting, Lee, Victor Ho Fan, Lee, Anne Wing Mui, Tsao, Sai Wah, Tsang, Chi Man
Additional file 1: Figure S1. IC50 values of palbociclib in different cancers as adapted from the Genomics of Drug Sensitivity in Cancer database [31] A. A mean Day-3 palbociclib IC50 of 35.7 μM was calculated from 770 cell lines corresponding to 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be39da75c2323912f64fbd9a86d938f
Autor:
Hiroya Kuwahara, Kazutaka Nishina, Takanori Yokota, Kotaro Yoshioka, Yutaro Asami, Tetsuya Nagata, Wenying Piao, Su Su Lei Mon, Kie Yoshida-Tanaka, Chunyan Jia, Taiki Kunieda
Publikováno v:
FEBS lettersReferences. 594(9)
Gapmer-type antisense oligonucleotides have not yet been approved for the treatment of central nervous system diseases, whereas steric-blocking-type antisense oligonucleotides have been well-developed for clinical use. We here characterize a new type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb9fed214524eac0309e9f7f8f3b8ac
https://pubmed.ncbi.nlm.nih.gov/31990989
https://pubmed.ncbi.nlm.nih.gov/31990989
Autor:
Hui Li, Chun Kit Yeung, Chin Wang Lau, Jason Y. K. Chan, Eileen Wong, Vivian Wai Yan Lui, Yuchen Liu, Hoi-Lam Ngan, Wenying Piao, Yu-xiong Su, Kwok Wai Lo, Peony Hiu Yan Poon
Publikováno v:
npj Genomic Medicine, Vol 5, Iss 1, Pp 1-5 (2020)
NPJ Genomic Medicine
NPJ Genomic Medicine
Head and neck squamous cell carcinoma (HNSCC) lacks predictive biomarkers for drug responses. By targeted sequencing, we identified two MAPK1 mutations in recurrent HNSCC, MAPK1p.D321N, and p.R135K. We previously reported an exceptional erlotinib res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b812af224dfdb3a99a36ff331bc9f9
https://pubmed.ncbi.nlm.nih.gov/32351709
https://pubmed.ncbi.nlm.nih.gov/32351709
Autor:
Jason Yik Kuen Chan, Hui Li, Kwok Wai Lo, Chun Kit Yeung, Chin Wang Lau, Peony Hiu Yan Poon, Yuchen Liu, Vivian Wai Yan Lui, Yu-xiong Su, Hoi Lam Ngan, Wenying Piao, Eileen Wong
Publikováno v:
Cancer Research. 80:1792-1792
The annual incidence of head and neck squamous cell carcinoma (HNSCC) is ~0.88 million worldwide (IARC, WHO 2018). Despite great success of precision medicine in major cancers such as lung cancer and breast cancers, there are limited precision therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b1170bd4edd75b279d850530f183ae5
https://doi.org/10.1158/1538-7445.am2020-1792
https://doi.org/10.1158/1538-7445.am2020-1792
Autor:
Wenying Piao, Takanori Yokota, Kazuki Sato, Sakie Hirochi, Takeshi Wada, Kazutaka Nishina, Futoshi Nakayama, Rintaro Iwata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:815-819
RNA interference (RNAi) is a promising tool to regulate gene expression by external double stranded RNAs (dsRNAs) such as siRNAs. As an efficient method to deliver siRNAs to liver cells, we propose a novel strategy using vitamin E (VE)-conjugated neo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac23921d105c48984353e70856bf7b1
https://doi.org/10.1016/j.bmcl.2014.12.079
https://doi.org/10.1016/j.bmcl.2014.12.079
Autor:
Laura Ren Huey Ip, Wenying Piao, Zoey Wing Yee Liu, Vivian Wai Yan Lui, Alan K. S. Chiang, Pui Chi Tsui, Yin-Fai Lee
Publikováno v:
Future oncology (London, England). 13(15)
Currently, out of the 82 US FDA-approved targeted therapies for adult cancer treatments, only three are approved for use in children irrespective of their genomic status. Apart from leukemia, only a handful of genomic-based trials involving children
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d6463e19f5da9b3558397cdefb776c
https://pubmed.ncbi.nlm.nih.gov/28589766
https://pubmed.ncbi.nlm.nih.gov/28589766