Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Wenyan Miao"'
Autor:
Fatemeh Moadab, Sepideh Sohrabi, Xiaoxing Wang, Rayan Najjar, Justina C. Wolters, Hua Jiang, Wenyan Miao, Donna Romero, Dennis M. Zaller, Megan Tran, Alison Bays, Martin S. Taylor, Rosana Kapeller, John LaCava, Tomas Mustelin
Publikováno v:
Mobile DNA, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with an unpredictable course of recurrent exacerbations alternating with more stable disease. SLE is characterized by broad immune activation and autoantibodies ag
Externí odkaz:
https://doaj.org/article/fe6226e258ca424d9883469888357136
Autor:
Jianli Xu, Wenyan Miao, Hailong Yuan, Ying Liu, Gang Chen, Hongbo Wang, Gulibadanmu Aizezi, Jianhua Qu, Xianlin Duan, Ruixue Yang, Maliya Muhashi, Chunxia Han, Linglu Ding, Nadiya Abulaiti, Nannan Pang, Le Zhang, Ming Jiang
Publikováno v:
Transplantation and Cellular Therapy. 29:331.e1-331.e8
Autor:
Silvana Leit, Jeremy R. Greenwood, Sayan Mondal, Samantha Carriero, Markus Dahlgren, Geraldine C. Harriman, Joshua J. Kennedy-Smith, Rosana Kapeller, Jon P. Lawson, Donna L. Romero, Angela V. Toms, Mee Shelley, Ronald T. Wester, William Westlin, Joshua J. McElwee, Wenyan Miao, Scott D. Edmondson, Craig E. Masse
Publikováno v:
Bioorganicmedicinal chemistry letters. 73
TYK2 is a member of the JAK family of kinases and a key mediator of IL-12, IL-23, and type I interferon signaling. These cytokines have been implicated in the pathogenesis of multiple inflammatory and autoimmune diseases such as psoriasis, rheumatoid
Autor:
Raghavendra G. Mirmira, Piero Marchetti, Wenyan Miao, Anne Op De Beeck, Lorella Marselli, Decio L. Eizirik, Craig Masse, Carmella Evans-Molina, Silvana Leit, Angela Castela, Alexandra Coomans de Brachène
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11f6f5b055279c0d9b90e054ff7e4e64
https://doi.org/10.1111/dom.14104/v2/response1
https://doi.org/10.1111/dom.14104/v2/response1
TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis
Autor:
Michael Zeng, Craig Masse, Melissa Lim, Natalia Yeremenko, Wenyan Miao, Dominika Hromadová, Mathias Müller, Robert D. Inman, Birgit Strobl, Zoya Qaiyum, Eric Gracey, William Westlin, Yuchen Yao, Yuriy Baglaenko, Archita Srinath
Publikováno v:
JOURNAL OF CLINICAL INVESTIGATION
Journal of clinical investigation, 130(4), 1863-1878. The American Society for Clinical Investigation
The Journal of Clinical Investigation
Journal of clinical investigation, 130(4), 1863-1878. The American Society for Clinical Investigation
The Journal of Clinical Investigation
Spondyloarthritis (SpA) represents a family of inflammatory diseases of the spine and peripheral joints. Ankylosing spondylitis (AS) is the prototypic form of SpA in which progressive disease can lead to fusion of the spine. Therapeutically, knowledg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadd856399c2267510c3909dfaeec434
https://biblio.ugent.be/publication/8729974
https://biblio.ugent.be/publication/8729974
Autor:
Heather Kelley, Carine Beysen, William F. Westlin, Tess Schmalbach, Kathryn Stiede, Geraldine Harriman, Rosana Kapeller, H. James Harwood, Heather S. Blanchette, Wenyan Miao
Publikováno v:
Hepatology (Baltimore, Md.)
NDI-010976, an allosteric inhibitor of acetyl-CoA carboxylases (ACC) ACC1 and ACC2, reduces hepatic de novo lipogenesis (DNL) and favorably affects steatosis, inflammation, and fibrosis in animal models of fatty liver disease. This study was a random
Autor:
Jennifer R. Brown, Divya Chaudhary, Bethany Tesar, Haesook T. Kim, Stacey M. Fernandes, Reuma Magori-Cohen, Lijian Yu, William F. Westlin, Siddha Kasar, Kevin Hoang, Ma. Reina Improgo, Wenyan Miao, Josephine L. Klitgaard
Publikováno v:
British Journal of Haematology.
The L265P somatic mutation in the Myeloid Differentiation Primary Response 88 (MYD88) gene is a recurrent mutation in chronic lymphocytic leukaemia (CLL). This mutation has functional effects in various haematological malignancies but its role in CLL
Autor:
Lixin Rui, Donna L. Romero, Divya Chaudhary, Shaughnessy Robinson, Louis M. Staudt, Rosana Kapeller, Wenyan Miao, Priscilla N. Kelly, Arthur L. Shaffer, Yibin Yang, William F. Westlin
Publikováno v:
The Journal of Experimental Medicine
Kelly et al. report the development of two highly selective and bioavailable small molecule IRAK4 inhibitors and show for the first time their therapeutic efficacy in autoimmune disorders and in a specific subset of diffuse large B cell lymphomas in
Autor:
Gregory R. Steinberg, Robert A. Foster, Wenyan Miao, Ting Wang, Vanessa P. Houde, Naoto Fujiwara, Hailing Sun, Jeremy R. Greenwood, Jennifer Rocnik, Geraldine Harriman, Danielle K. DePeralta, Theodoros Tsakiridis, Asish K. Saha, Lan Wei, Jamie Bates, Alexander E. Anagnostopoulos, Alice Wang, Henry Liu, Kenneth K. Tanabe, Omeed Moaven, Paola Muti, Yujin Hoshida, Derek J. Erstad, William F. Westlin, Rebecca J. Ford, Ricard Masia, James S. V. Lally, Bryan C. Fuchs, Adrian S. Ray, H. James Harwood, Lindsay A. Broadfield, Sarani Ghoshal, Rosana Kapeller, Vivian Leong, Sathesh Bhat
Publikováno v:
Cell Metabolism
Cell Metabolism, Elsevier, 2019, 29 (1), pp.174-182.e5. ⟨10.1016/j.cmet.2018.08.020⟩
Cell Metabolism, Elsevier, 2019, 29 (1), pp.174-182.e5. ⟨10.1016/j.cmet.2018.08.020⟩
International audience; The incidence of hepatocellular carcinoma (HCC) is rapidly increasing due to the prevalence of obesity and non-alcoholic fatty liver disease, but the molecular triggers that initiate disease development are not fully understoo
Autor:
Jennifer Rocnik, Koshi Akahane, Craig E. Masse, David M. Weinstock, Jeremy R. Greenwood, Takaomi Sanda, Zhaodong Li, Wenyan Miao, Hong L. Tiv, Rosana Kapeller, Evisa Gjini, Julia Etchin, A. Thomas Look, Alla Berezovskaya
Activation of tyrosine kinase 2 (TYK2) contributes to the aberrant survival of T-cell acute lymphoblastic leukaemia (T-ALL) cells. Here we demonstrate the anti-leukaemic activity of a novel TYK2 inhibitor, NDI-031301. NDI-031301 is a potent and selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2108955c41be4e1418f71b5af0cc5661
https://europepmc.org/articles/PMC5384871/
https://europepmc.org/articles/PMC5384871/