Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Wenxuan Zhen"'
Autor:
Yangzhuoqun Wan, Shuangshuang Guo, Wenxuan Zhen, Lizhen Xu, Xiaoying Chen, Fangyue Liu, Yi Shen, Shuangshuang Liu, Lidan Hu, Xinyan Wang, Fengcan Ye, Qinrui Wang, Han Wen, Fan Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The ClC-3 chloride/proton exchanger is both physiologically and pathologically critical, as it is potentiated by ATP to detect metabolic energy level and point mutations in ClC-3 lead to severe neurodegenerative diseases in human. However, w
Externí odkaz:
https://doaj.org/article/54c45cb442f54cd89937965b7a2e918a
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/f93e68f5717649319e3edee197a3198b
Autor:
Xiafei Yu, Yuan Xie, Xiaokang Zhang, Cheng Ma, Likun Liu, Wenxuan Zhen, Lingyi Xu, Jianmin Zhang, Yan Liang, Lixia Zhao, Xiuxia Gao, Peilin Yu, Jianhong Luo, Lin-Hua Jiang, Yan Nie, Fan Yang, Jiangtao Guo, Wei Yang
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110025- (2021)
Summary: Transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable cation channel, is gated by intracellular adenosine diphosphate ribose (ADPR), Ca2+, warm temperature, and oxidative stress. It is critically involved in physiological and p
Externí odkaz:
https://doaj.org/article/033b93d8d1d24aa1ad3a824d21df3eb9
Autor:
Nannan Su, Wenxuan Zhen, Heng Zhang, Lingyi Xu, Yitian Jin, Xiaoying Chen, Cheng Zhao, Qinrui Wang, Xinyan Wang, Shaowei Li, Han Wen, Wei Yang, Jiangtao Guo, Fan Yang
Publikováno v:
Nature Chemical Biology. 19:72-80
The transient receptor potential vanilloid 2 (TRPV2) ion channel is a polymodal receptor widely involved in many physiological and pathological processes. Despite many TRPV2 modulators being identified, whether and how TRPV2 is regulated by endogenou
Autor:
Wenxuan Zhen, Fan Yang, Jie-Bo Lin, Shan-He Yu, Xiao-Jian Sun, Yi-Fan Wang, Dan Wang, Chih-Hung Hsu, Yu-Han Wu, Yi Zhou, Peng-Fei Xu, Yi Wang, Li-Ping Shu, Ying Huang, Tao Cheng, Yi Chen
Publikováno v:
Theranostics
Rationale: Tanshinone, a type of diterpenes derived from salvia miltiorrhiza, is a particularly promising herbal medicine compound for the treatment of cancers including acute myeloid leukemia (AML). However, the therapeutic function and the underlyi
Autor:
Lizhen Xu, Xiao Liang, Wenxuan Zhen, Zhangzhi Xue, Fangfei Zhang, Xiao Yi, Xiaoying Chen, Lidan Hu, Bei Li, Bing Zhang, Yuhang Wang, Zhenfeng Deng, Wei Yang, Han Wen, Tiannan Guo, Yi Zhu, Fan Yang
SUMMARYDetecting temperature is crucial for the survival of living organisms. Though the thermo transient receptor potential (thermoTRP) channels, such as TRPV1 or TRPM8, have been identified as prototypic heat or cold sensors, respectively, how they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35a8e98a600ccd1a749fd7dd6ef7e9c2
https://doi.org/10.1101/2022.05.23.493163
https://doi.org/10.1101/2022.05.23.493163
Autor:
Jiawu Yan, Zhongyuan Wang, Guojian Bao, Cailin Xue, Wenxuan Zheng, Rao Fu, Minglu Zhang, Jialu Ding, Fei Yang, Beicheng Sun
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Background Observational studies have reported that gut microbiota composition is associated with metabolic syndrome. However, the causal effect of gut microbiota on metabolic syndrome has yet to be confirmed. Methods We performed a bidirect
Externí odkaz:
https://doaj.org/article/8b130f4414d74181bcf6a3cbacafab92
Autor:
Hao Li, Xiufen Zhang, Xiaowen Wang, Qilin Wu, Wenxuan Zheng, Chuang Liu, Shi Wei, Xin Zuo, Wenquan Xiao, Hui Ye, Wence Wang, Lin Yang, Yongwen Zhu
Publikováno v:
Poultry Science, Vol 103, Iss 9, Pp 103929- (2024)
ABSTRACT: This study aimed to investigate the developmental change of body growth and gene expression related to fatty acid uptake and oxidation in the yolk sac membrane (YSM) and jejunum during embryogenesis in Muscovy ducks. The weights of embryos
Externí odkaz:
https://doaj.org/article/650e1d6624fb4c63929ff9e6b8c67dba
Autor:
Wei Yang, Yan Nie, Wenxuan Zhen, Lingyi Xu, Lin-Hua Jiang, Yuan Xie, Yan Liang, Likun Liu, Cheng Ma, Peilin Yu, Lixia Zhao, Xiuxia Gao, Xiaokang Zhang, Jiangtao Guo, Jianhong Luo, Jianmin Zhang, Xiafei Yu, Fan Yang
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110025-(2021)
Summary: Transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable cation channel, is gated by intracellular adenosine diphosphate ribose (ADPR), Ca2+, warm temperature, and oxidative stress. It is critically involved in physiological and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708baa4ea1ebf9c1b5571d067552e541
https://eprints.whiterose.ac.uk/181142/1/1-s2.0-S2211124721015072-main.pdf
https://eprints.whiterose.ac.uk/181142/1/1-s2.0-S2211124721015072-main.pdf
Autor:
Mobai, Li, Dehang, Yang, Huige, Yan, Zhibin, Tang, Danlu, Jiang, Jian, Zhang, Zhexu, Chi, Wanyun, Nie, Wenxuan, Zhen, Weiwei, Yu, Sheng, Chen, Zhen, Wang, Qianzhou, Yu, Xue, Zhang, Fan, Yang, Shunwu, Fan, Xianfeng, Lin, Di, Wang
Publikováno v:
Developmental Cell. 57:2365-2380.e8
Gasdermin D (GSDMD)-mediated pyroptosis induces immunogenic cell death and promotes inflammation. However, the functions of GSDMD in tissue homeostasis remain unclear. Here, we identify a physiological function of GSDMD in osteoclasts via a non-lytic