Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Wenxia Yu"'
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
ObjectiveTo comprehensively assess the global burden of syphilis and related risk factors over 1990–2021, forecast future disease trends, and understand the impact of syphilis on global health.MethodsGlobal Burden of Disease Study 2021 (GBD 2021) d
Externí odkaz:
https://doaj.org/article/b68737dfb0d641e585d4f52589fbf0aa
Autor:
Xiaofang Cao, Junfan Guo, Shisheng Huang, Wenxia Yu, Guanglei Li, Lisha An, Xiangyang Li, Wanyu Tao, Qing Liu, Xingxu Huang, Xiaohua Jin, Xu Ma
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 732-742 (2022)
About 47% of pathogenic point mutations could be corrected by ABE-induced A·T-to-G·C conversions. However, the applications of ABEs are still hindered by undesired editing efficiency, limited editing scopes, and off-targeting effects. Here, we deve
Externí odkaz:
https://doaj.org/article/a9cbccc76e424edcbb1a6a5837826a3d
Autor:
Zhean Li, Lingling Luo, Wenxia Yu, Ping Li, Danfeng Ou, Jia Liu, Hanhui Ma, Qinhu Sun, Aibin Liang, Cheng Huang, Tian Chi, Xingxu Huang, Yu Zhang
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-15 (2022)
Abstract Peroxisome proliferator-activated receptor (PPAR)-γ is a key transcription activator controlling adipogenesis and lipid metabolism. PPARγ binds PPAR response elements (PPREs) as the obligate heterodimer with retinoid X receptor (RXR) α, b
Externí odkaz:
https://doaj.org/article/7a310094cc5a4266bbd7aac9a6ab04eb
Autor:
Jianxiang Lin, Xingchen Liu, Zongyang Lu, Shisheng Huang, Susu Wu, Wenxia Yu, Yao Liu, Xiaoguo Zheng, Xingxu Huang, Qiang Sun, Yunbo Qiao, Zhen Liu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 494-501 (2021)
Prime editing enables efficient introduction of targeted transversions, insertions, and deletions in mammalian cells and several organisms. However, genetic disease models with base deletions by prime editing have not yet been reported in mice. Here,
Externí odkaz:
https://doaj.org/article/6660187d2dc3426d8bc611ea355af90e
Autor:
Jianan Li, Jianxiang Lin, Shisheng Huang, Min Li, Wenxia Yu, Yuting Zhao, Junfan Guo, Pumin Zhang, Xingxu Huang, Yunbo Qiao
Publikováno v:
Advanced Science, Vol 9, Iss 30, Pp n/a-n/a (2022)
Abstract Selective inhibition of targeted protein kinases is an effective therapeutic approach for treatment of human malignancies, which interferes phosphorylation of cellular substrates. However, a drug‐imposed selection creates pressures for tum
Externí odkaz:
https://doaj.org/article/3138ac8b45f34d1c87bd25c3ed52f91a
Autor:
Jianan Li, Wenxia Yu, Shisheng Huang, Susu Wu, Liping Li, Jiankui Zhou, Yu Cao, Xingxu Huang, Yunbo Qiao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Base editors can induce transcriptome-wide RNA off-target editing independent of gRNA. Here, the authors engineer ABEmax variants with minimized RNA off-target activities.
Externí odkaz:
https://doaj.org/article/4bd9786b378c4e9cb51a4b505bd69951
Autor:
Wenxia Yu, Jianan Li, Shisheng Huang, Xiangyang Li, Ping Li, Guanglei Li, Aibin Liang, Tian Chi, Xingxu Huang
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-11 (2021)
Abstract Background Site-specific C>T DNA base editing has been achieved by recruiting cytidine deaminases to the target C using catalytically impaired Cas proteins; the target C is typically located within 5-nt editing window specified by the guide
Externí odkaz:
https://doaj.org/article/5e9032093297405fb925915e12395cb0
Autor:
Xiuhai Su, Wenxia Yu, Airu Liu, Congxiang Wang, Xiuzhen Li, Juanjuan Gao, Xiaofei Liu, Wenhui Jiang, Yue Yang, Shuquan Lv
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
San-Huang-Yi-Shen capsule (SHYS) has been used in the treatment of diabetic nephropathy (DN) in clinic. However, the mechanisms of SHYS on DN remain unknown. In this study, we used a high-fat diet (HFD) combined with streptozotocin (STZ) injection to
Externí odkaz:
https://doaj.org/article/30756142961d4a6b8954c6aa579f5b55
Autor:
Xiao Wang, Chengfeng Ding, Wenxia Yu, Ying Wang, Siting He, Bei Yang, Yi-Chun Xiong, Jia Wei, Jifang Li, Jiayi Liang, Zongyang Lu, Wei Zhu, Jing Wu, Zhi Zhou, Xingxu Huang, Zhen Liu, Li Yang, Jia Chen
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: The advent of base editors (BEs) holds great potential for correcting pathogenic-related point mutations to treat relevant diseases. However, Cas9 nickase (nCas9)-derived BEs lead to DNA double-strand breaks, which can trigger unwanted DNA d
Externí odkaz:
https://doaj.org/article/b2929ee16b7d43649d54cf47e28a6ed2
Autor:
Zhen Liu, Zongyang Lu, Guang Yang, Shisheng Huang, Guanglei Li, Songjie Feng, Yajing Liu, Jianan Li, Wenxia Yu, Yu Zhang, Jia Chen, Qiang Sun, Xingxu Huang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
CRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.
Externí odkaz:
https://doaj.org/article/8958562bd535472e9a0b1a20d9353429