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Akademický článek

Criteria of strong nearest-cross points and strong best approximation pairs

Autor: Wenxi Pan, Jingshi Xu

Publikováno v: Applied General Topology, Vol 7, Iss 1, Pp 41-50 (2006)

The concept of strong nearest-cross point (strong n.c. point) is introduced, which is the generalization of strong uniqueness of best approximation from a single point. The relation connecting to localization is discussed. Some criteria of strong n.c

Externí odkaz: https://doaj.org/article/0f28f23f01384fd8bbf60ece3a382dff

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Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:5303-5307

Complement C1s protease inhibitors have potential utility in the treatment of diseases associated with activation of the classical complement pathway such as humorally mediated graft rejection, ischemia-reperfusion injury (IRI), vascular leak syndrom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44891a19d07c75d5617cf44b0ba3e337
https://doi.org/10.1016/j.bmcl.2012.06.030

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Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:1603-1606

Complement activation has been implicated in disease states such as hereditary angioedema, ischemia-reperfusion injury, acute respiratory distress syndrome, and acute transplant rejection. Even though the complement cascade provides several protein t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06eefcfefc962ecd7776e95a4980fdd8
https://doi.org/10.1016/j.bmcl.2008.01.064

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2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors

Autor: Tianbao Lu, Carl Crysler, Wenxi Pan, Kevin D. Kreutter, Lily Lee, Bruce E. Tomczuk, John C. Spurlino, Mark R. Player

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 17:6266-6269

2-(2-Chloro-6-fluorophenyl)acetamides having 2,2-difluoro-2-aryl/heteroaryl-ethylamine P3 and oxyguanidine P1 substituents are potent thrombin inhibitors ( K i = 0.9–33.9 nM). 2-(5-Chloro-pyridin-2-yl)-2,2-difluoroethylamine was the best P3 substit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e6a9d9e784bd8de207633058465928
https://doi.org/10.1016/j.bmcl.2007.09.013

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Novel potent and selective αvβ3/αvβ5 integrin dual antagonists with reduced binding affinity for human serum albumin

Autor: Juan Jose Marugan, Wenxi Pan, Carl Crysler, Carl L. Manthey, Margery A. Chaikin, Bruce E. Tomczuk, Kristi A. Leonard, Jennifer Lattanze, Pierre Raboisson

Publikováno v: European Journal of Medicinal Chemistry. 41:847-861

The binding of lead compounds and drugs to human serum albumin (HSA) is a ubiquitous problem in drug discovery since it modulates the availability of the leads and drugs to their intended target, which is linked to biological efficacy. In our continu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c22317ecbd6b92e2acbc8f24dc9116e
https://doi.org/10.1016/j.ejmech.2006.03.008

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Criteria of strong nearest-cross points and strong best approximation pairs

Autor: Jingshi Xu, Wenxi Pan

Publikováno v: Applied General Topology, Vol 7, Iss 1, Pp 41-50 (2006)
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
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[EN] The concept of strong nearest-cross point (strong n.c. point) is introduced, which is the generalization of strong uniqueness of best approximation from a single point. The relation connecting to localization is discussed. Some criteria of stron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e05bc477aabd32475236e5de901998d
http://polipapers.upv.es/index.php/AGT/article/view/1931

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A functional radioreceptor assay of alpha-V-beta-3 (αvβ3) inhibitors in plasma: Application as an ex vivo pharmacodynamic model

Autor: Carl L. Manthey, Juan J. Marugan, Beth M. Anaclerio, Zihong Guo, Kristi A. Leonard, Bruce E. Tomczuk, Peter Baciu, Ming Ni, Jeffrey L. Edelman, Margery A. Chaikin, Stephen Eisennagel, Gerald W. De Vries, Christopher J. Molloy, Wenxi Pan

Publikováno v: Journal of Biochemical and Biophysical Methods. 65:107-120

Development of alphavbeta3-integrin inhibitors has been hampered by a lack of pharmacodynamic endpoints to identify doses that inhibit alphavbeta3 in vivo. To address this need, we developed an alphavbeta3 radioreceptor assay (RRA) that could be perf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52b65b36a6a6cb092f8652c538d4505
https://doi.org/10.1016/j.jbbm.2005.10.004

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Platelet Factor 4 Activity against P. falciparum and Its Translation to Nonpeptidic Mimics as Antimalarials

Autor: Michael J. Costanzo, M. Anna Kowalska, Richard W. Scott, William F. DeGrado, Katie B. Freeman, Wenxi Pan, Hyunil Jo, Doron C. Greenbaum, Lawrence W. Bergman, Satish Mishra, Thomas M. Daly, Robert W. Kavash, Swapnil J. Kulkarni, Mortimer Poncz, Melanie G. Millholland, Melissa S. Love, Dewight Williams, Photini Sinnis

Publikováno v: Cell host & microbe, vol 12, iss 6

SummaryPlasmodium falciparum pathogenesis is affected by various cell types in the blood, including platelets, which can kill intraerythrocytic malaria parasites. Platelets could mediate these antimalarial effects through human defense peptides (HDPs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5892882964f189700f075c8e46ccbcd
https://europepmc.org/articles/PMC3638032/

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Synthetic mimics of antimicrobial peptides with immunomodulatory responses

Autor: Wenxi Pan, Furkan Ayaz, Hitesh D. Thaker, Richard W. Scott, Juan Anguita, Abhigyan Som, Dahui Lui, Gregory N. Tew

Publikováno v: Journal of the American Chemical Society. 134(27)

A new series of aryl-based synthetic mimics of antimicrobial peptides (SMAMPs) with antimicrobial activity and selectivity have been developed via systematic tuning of the aromatic groups and charge. The addition of a pendant aromatic group improved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad652d0ae124a164cdbf7d88d689d4f7
https://pubmed.ncbi.nlm.nih.gov/22697149

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