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Akademický článek

Subversion of selective autophagy for the biogenesis of tombusvirus replication organelles inhibits autophagy.

Autor: Yuanrong Kang, Wenwu Lin, Peter D Nagy

Publikováno v: PLoS Pathogens, Vol 20, Iss 3, p e1012085 (2024)

Elaborate viral replication organelles (VROs) are formed to support positive-strand RNA virus replication in infected cells. VRO formation requires subversion of intracellular membranes by viral replication proteins. Here, we showed that the key ATG8

Externí odkaz: https://doaj.org/article/71beb5cbf5314101aa589d5523866ad0

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Akademický článek

A novel viral strategy for host factor recruitment: The co-opted proteasomal Rpn11 protein interaction hub in cooperation with subverted actin filaments are targeted to deliver cytosolic host factors for viral replication.

Autor: Melissa Molho, Wenwu Lin, Peter D Nagy

Publikováno v: PLoS Pathogens, Vol 17, Iss 6, p e1009680 (2021)

Positive-strand (+)RNA viruses take advantage of the host cells by subverting a long list of host protein factors and transport vesicles and cellular organelles to build membranous viral replication organelles (VROs) that support robust RNA replicati

Externí odkaz: https://doaj.org/article/96e0c8a0cfd643a3bced43415ec9bf29

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Akademický článek

Dynamic interplay between the co-opted Fis1 mitochondrial fission protein and membrane contact site proteins in supporting tombusvirus replication.

Autor: Wenwu Lin, Zhike Feng, K Reddisiva Prasanth, Yuyan Liu, Peter D Nagy

Publikováno v: PLoS Pathogens, Vol 17, Iss 3, p e1009423 (2021)

Plus-stranded RNA viruses have limited coding capacity and have to co-opt numerous pro-viral host factors to support their replication. Many of the co-opted host factors support the biogenesis of the viral replication compartments and the formation o

Externí odkaz: https://doaj.org/article/4bd1c0b277a64dc4926a77d0d9f5087d

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Akademický článek

Co-opting the fermentation pathway for tombusvirus replication: Compartmentalization of cellular metabolic pathways for rapid ATP generation.

Autor: Wenwu Lin, Yuyan Liu, Melissa Molho, Shengjie Zhang, Longshen Wang, Lianhui Xie, Peter D Nagy

Publikováno v: PLoS Pathogens, Vol 15, Iss 10, p e1008092 (2019)

The viral replication proteins of plus-stranded RNA viruses orchestrate the biogenesis of the large viral replication compartments, including the numerous viral replicase complexes, which represent the sites of viral RNA replication. The formation an

Externí odkaz: https://doaj.org/article/ab1dea2c43fb419db016a3beb356b014

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Akademický článek

Taking over Cellular Energy-Metabolism for TBSV Replication: The High ATP Requirement of an RNA Virus within the Viral Replication Organelle

Autor: Peter D. Nagy, Wenwu Lin

Publikováno v: Viruses, Vol 12, Iss 1, p 56 (2020)

Recent discoveries on virus-driven hijacking and compartmentalization of the cellular glycolytic and fermentation pathways to support robust virus replication put the spotlight on the energy requirement of viral processes. The active recruitment of g

Externí odkaz: https://doaj.org/article/5560c4de7e224cdca7f40bb4496ec067

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Decreased frequency of a novel T‐lymphocyte subset, CD3 + CD4 − CD7 + CD57 − T cells, in hepatitis B virus‐related end‐stage liver disease might contribute to disease progression

Autor: Xueping Yu, Yijuan Zheng, Dawu Zeng, Yongjun Zhou, Jian Sun, Milong Su, Huatang Zhang, Minhui Zheng, Zhipeng Huang, Wenwu Lin, Richeng Mao, Jiming Zhang, Chunfu Zheng, Zhijun Su

Publikováno v: Journal of Medical Virology. 95

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::208b738860b412ecf65c0eb7f234c83f
https://doi.org/10.1002/jmv.28129

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Key tethering function of Atg11 autophagy scaffold protein in formation of virus-induced membrane contact sites during tombusvirus replication

Autor: Yuanrong Kang, Wenwu Lin, Yuyan Liu, Peter D. Nagy

Publikováno v: Virology. 572

Positive-strand RNA viruses induce the biogenesis of viral replication organelles (VROs), which support viral replication in infected cells. VRO formation requires viral replication proteins, co-opted host factors and intracellular membranes. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e88e04226e7befbe24608f942c4b7cf
https://pubmed.ncbi.nlm.nih.gov/35533414

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Co-opted Cellular Sac1 Lipid Phosphatase and PI(4)P Phosphoinositide Are Key Host Factors during the Biogenesis of the Tombusvirus Replication Compartment

Autor: Jun-ichi Inaba, Nikolay Kovalev, Wenwu Lin, Peter D. Nagy, Kai Xu, Zsuzsanna Sasvari

Publikováno v: J Virol

Positive-strand RNA [(+)RNA] viruses assemble numerous membrane-bound viral replicase complexes (VRCs) with the help of viral replication proteins and co-opted host proteins within large viral replication compartments in the cytosol of infected cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5c1560259305379adde02963c7b9b7
https://doi.org/10.1128/jvi.01979-19

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Targeting of rice grassy stunt virus pc6 protein to plasmodesmata requires the ER-to-Golgi secretory pathway and an actin-myosin VIII motility system

Autor: Liang Yang, Xiaojuan Liu, Zujian Wu, Wenwu Lin, Xuelian Sui

Publikováno v: Archives of Virology. 163:1317-1323

The nonstructural protein pc6 encoded by rice grassy stunt virus (RGSV) plays a significant role in viral cell-to-cell movement, presumably by transport through plasmodesmata (PD). We confirmed the association of pc6 with PD, and also elucidated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeea70df4ad870e8f8028a06a6687634
https://doi.org/10.1007/s00705-018-3726-9

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