Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Wenwen Lei"'
Autor:
Bo Liu, Honghui Liu, Pu Han, Xiaoyun Wang, Chunmei Wang, Xinxin Yan, Wenwen Lei, Ke Xu, Jianjie Zhou, Jianxun Qi, Ruiwen Fan, Guizhen Wu, Wen-xia Tian, George F. Gao, Qihui Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Almost all the neutralizing antibodies targeting the receptor-binding domain (RBD) of spike (S) protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged or emerging variants, such as
Externí odkaz:
https://doaj.org/article/58723ee042ad435f85dba65f7ee234a2
Publikováno v:
Biosafety and Health, Vol 6, Iss 2, Pp 80-87 (2024)
The emerging viruses within the genus Henipavirus in the family Paramyxoviridae pose a great threat to public biosafety. To develop a quadruple real-time fluorescence-based quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay
Externí odkaz:
https://doaj.org/article/52e69106a75c462989d98bd989865a70
Autor:
Zhou Tong, Jianyu Tong, Wenwen Lei, Yufeng Xie, Yingzi Cui, Guowen Jia, Shihua Li, Zezhong Zhang, Zhimin Cheng, Xiao Xing, Haiyun Ma, Lan Deng, Rong Zhang, Xin Zhao, Kefang Liu, Qihui Wang, Jianxun Qi, Haomin Huang, Rui Song, Zhaoming Su, Guizhen Wu, Jing Lou, George Fu Gao
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114338- (2024)
Summary: The game between therapeutic monoclonal antibodies (mAbs) and continuously emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has favored the virus, as most therapeutic mAbs have been evaded. Addressing this chall
Externí odkaz:
https://doaj.org/article/a73e673f4b47432cb7e3e0b7cbab3ca8
Autor:
Jingyun Yang, Weiqi Hong, Hong Lei, Cai He, Wenwen Lei, Yanan Zhou, Tingmei Zhao, Aqu Alu, Xuelei Ma, Jiong Li, Li Yang, Zhenling Wang, Wei Wang, Guangwen Lu, Guobo Shen, Shuaiyao Lu, Guizhen Wu, Huashan Shi, Xiawei Wei
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract The COVID-19 response strategies in Chinese mainland were recently adjusted due to the reduced pathogenicity and enhanced infectivity of Omicron subvariants. In Chengdu, China, an infection wave was predominantly induced by the BA.5 subvaria
Externí odkaz:
https://doaj.org/article/8aab6045978541f78f42a3cf5965ed05
Autor:
Yulei Li, Peipei Liu, Tianjiao Hao, Sheng Liu, Xi Wang, Yufeng Xie, Ke Xu, Wenwen Lei, Cheng Zhang, Pu Han, Ying Li, Xiyue Jin, Yu Huan, Yafei Lu, Rong Zhang, Xiaoyan Li, Xin Zhao, Kun Xu, Pu Liao, Xuancheng Lu, Yuhai Bi, Hao Song, Guizhen Wu, Baoli Zhu, George F. Gao
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
Highly contagious respiratory illnesses like influenza and COVID-19 pose serious risks to public health. A two-in-one vaccine would be ideal to avoid multiple vaccinations for these diseases. Here, we generated a chimeric receptor binding domain of t
Externí odkaz:
https://doaj.org/article/78b599e9f4e1408ba9f1981250f3f088
Autor:
Yanfang Zhang, Xinrui Kang, Sheng Liu, Pu Han, Wenwen Lei, Ke Xu, Zepeng Xu, Zhengrong Gao, Xuemei Zhou, Yaling An, Yuxuan Han, Kefang Liu, Xin Zhao, Lianpan Dai, Peiyi Wang, Guizhen Wu, Jianxun Qi, Kun Xu, George F Gao
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011659 (2023)
SARS-CoV-2 variants with severe immune evasion are a major challenge for COVID-19 prevention, especially the circulating Omicron XBB/BQ.1.1/BF.7 strains. Thus, the next-generation of broad-spectrum vaccines are urgently needed. Previously, we develop
Externí odkaz:
https://doaj.org/article/dee577a6f1524b6fa72c01b3e0d331b1
Autor:
Ying Lin, Xiaozhou He, Wenwen Lei, Zhiyuan Jia, Jue Liu, Cunrui Huang, Jingkun Jiang, Qihui Wang, Fengqin Li, Wei Ma, Min Liu, George F. Gao, Guizhen Wu, Jun Liu
Publikováno v:
Global Transitions, Vol 5, Iss , Pp 170-181 (2023)
During the COVID-19 pandemic, a series of outbreaks and related investigations have indicated that the virus can be transmitted via cold-chain environment media. The causal relationship between the cold chain and the introduction and spread of viruse
Externí odkaz:
https://doaj.org/article/a39161ee73c848a4874ccb073a3fae73
Autor:
Nawal Al Kaabi, Yun Kai Yang, Yu Liang, Ke Xu, Xue Feng Zhang, Yun Kang, Yu Qin Jin, Jun Wei Hou, Jing Zhang, Tian Yang, Salah Hussein, Mohamed Saif ElDein, Ze Hua Lei, Hao Zhang, Shuai Shao, Zhao Ming Liu, Ning Liu, Xiang Zheng, Ji Guo Su, Sen Sen Yang, Xiangfeng Cong, Yao Tan, Wenwen Lei, Xue Jun Gao, Zhiwei Jiang, Hui Wang, Meng Li, Hanadi Mekki Mekki, Walid Zaher, Sally Mahmoud, Xue Zhang, Chang Qu, Dan Ying Liu, Mengjie Yang, Islam Eltantawy, Peng Xiao, Fu Jie Shen, Jin Juan Wu, Zi Bo Han, Li Fang Du, Fang Tang, Shi Chen, Zhi Jing Ma, Fan Zheng, Ya Nan Hou, Xin Yu Li, Xin Li, Zhao Nian Wang, Jin Liang Yin, Xiao Yan Mao, Jin Zhang, Liang Qu, Yun Tao Zhang, Xiao Ming Yang, Guizhen Wu, Qi Ming Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract An ongoing randomized, double-blind, controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate, named NVSI-06-09, as a booster dose in subjects aged 18 years and older fro
Externí odkaz:
https://doaj.org/article/4d623a0b2acb4327bb2ad5f697eb16f3
Autor:
Nawal Al Kaabi, Yun Kai Yang, Li Fang Du, Ke Xu, Shuai Shao, Yu Liang, Yun Kang, Ji Guo Su, Jing Zhang, Tian Yang, Salah Hussein, Mohamed Saif ElDein, Sen Sen Yang, Wenwen Lei, Xue Jun Gao, Zhiwei Jiang, Xiangfeng Cong, Yao Tan, Hui Wang, Meng Li, Hanadi Mekki Mekki, Walid Zaher, Sally Mahmoud, Xue Zhang, Chang Qu, Dan Ying Liu, Mengjie Yang, Islam Eltantawy, Jun Wei Hou, Ze Hua Lei, Peng Xiao, Zhao Nian Wang, Jin Liang Yin, Xiao Yan Mao, Jin Zhang, Liang Qu, Yun Tao Zhang, Xiao Ming Yang, Guizhen Wu, Qi Ming Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
SARS-CoV-2 variants with immune escape capability highlight the need for the development of cross-neutralising vaccines and regimens. Here, the authors assess the immunogenicity and safety of NVSI-06-08, that integrates antigens from multiple SARS-Co
Externí odkaz:
https://doaj.org/article/f2cc9bdd0cd344e49d5f119c751716d3
Autor:
Nawal Al Kaabi, Yun Kai Yang, Jing Zhang, Ke Xu, Yu Liang, Yun Kang, Ji Guo Su, Tian Yang, Salah Hussein, Mohamed Saif ElDein, Shuai Shao, Sen Sen Yang, Wenwen Lei, Xue Jun Gao, Zhiwei Jiang, Hui Wang, Meng Li, Hanadi Mekki Mekki, Walid Zaher, Sally Mahmoud, Xue Zhang, Chang Qu, Dan Ying Liu, Mengjie Yang, Islam Eltantawy, Peng Xiao, Zhao Nian Wang, Jin Liang Yin, Xiao Yan Mao, Jin Zhang, Ning Liu, Fu Jie Shen, Liang Qu, Yun Tao Zhang, Xiao Ming Yang, Guizhen Wu, Qi Ming Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract The increased coronavirus disease 2019 (COVID-19) breakthrough cases pose the need of booster vaccination. We conducted a randomised, double-blinded, controlled, phase 2 trial to assess the immunogenicity and safety of the heterologous prime
Externí odkaz:
https://doaj.org/article/c1df52b85da34e63b5c7dfaf04c077f6