Mechanism of selective recognition of Lys48-linked polyubiquitin by macrocyclic peptide inhibitors of proteasomal degradation.

Autor: Lemma B; Center for Biomolecular Structure and Organization, Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA., Zhang D; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA., Vamisetti GB; Schulich Faculty of Chemistry, Technion - Israel Institute of Technology, Haifa, 3200008, Israel., Wentz BG; Center for Biomolecular Structure and Organization, Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA., Suga H; Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, 7-3-1 Hongo, Bunkyo, Tokyo, 113-0033, Japan., Brik A; Schulich Faculty of Chemistry, Technion - Israel Institute of Technology, Haifa, 3200008, Israel. abrik@technion.ac.il., Lubkowski J; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA. jacek.lubkowski2@nih.gov., Fushman D; Center for Biomolecular Structure and Organization, Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA. fushman@umd.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Nov 08; Vol. 14 (1), pp. 7212. Date of Electronic Publication: 2023 Nov 08.