Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Wenshu Zeng"'
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102750- (2023)
Summary: Studying skeletal muscle stem cells (MuSCs) quiescence is challenging as they quickly activate within hours of isolation from muscle. Here, we present a protocol to disassociate and characterize fixed peptides from quiescent MuSCs using trap
Externí odkaz:
https://doaj.org/article/febedd1e3a5d4a85a647591a1a910288
Autor:
Wenqiang Liu, Wenshu Zeng, Xiaohui Kong, Min Htet, Rebecca Yu, Matthew Wheeler, John W. Day, Joseph C. Wu
Publikováno v:
Stem Cell Research, Vol 72, Iss , Pp 103207- (2023)
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder that leads to death in early adulthood. Patients with DMD have null mutations leading to loss of functional dystrophin protein. Here we generated two DMD induced pluripotent stem cel
Externí odkaz:
https://doaj.org/article/aa3f872aa7874a50ba5ab5ab8227e0f0
Autor:
Xiaohui Kong, Nadjet Belbachir, Wenshu Zeng, Christopher D. Yan, Sai Navada, Marco V. Perez, Joseph C. Wu
Publikováno v:
Stem Cell Research, Vol 69, Iss , Pp 103111- (2023)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a congenital arrhythmic syndrome caused by the RYR2 gene encoded ryanodine receptor. Mutations on RYR2 are commonly associated with ventricular tachycardia after adrenergic stimulation,
Externí odkaz:
https://doaj.org/article/103728abecbf43808601502b4e9d7a2f
Autor:
Wenshu Zeng, Xiaohui Kong, Christina Alamana, Yu Liu, Jessica Guzman, Paul D. Pang, John W. Day, Joseph C. Wu
Publikováno v:
Stem Cell Research, Vol 69, Iss , Pp 103095- (2023)
Spinal muscular atrophy (SMA) is a severe neurodegenerative muscular disease caused by the homozygous loss of survival of motor neuron 1 (SMN1) genes. SMA patients exhibit marked skeletal muscle (SKM) loss, eventually leading to death. Here we genera
Externí odkaz:
https://doaj.org/article/3d79c9b2116f4cf6baf9bc56f63248eb
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Skeletal muscle stem cells are actively maintained in quiescence, but can activate quickly upon extrinsic stimulation. Here the authors show that CPEB1 promotes muscle stem cell activation by reprogramming the translational landscape.
Externí odkaz:
https://doaj.org/article/35b0f05cee4a497faebd402acaa23bb2
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104954- (2022)
Summary: Regulation of chromatin accessibility is critical for cell fate decisions. Chromatin structure responds to extrinsic environments rapidly. The traditional adult stem cell isolation approach requires tissue dissociation, which triggers stem c
Externí odkaz:
https://doaj.org/article/f33fd75d1f624c4e8a537454cd07cae5
Autor:
Wenshu, Zeng, Lu, Yue, Kim S W, Lam, Wenxin, Zhang, Wai-Kin, So, Erin H Y, Tse, Tom H, Cheung
Publikováno v:
Nature communications. 13(1)
Skeletal muscle stem cells, also called Satellite Cells (SCs), are actively maintained in quiescence but can activate quickly upon extrinsic stimuli. However, the mechanisms of how quiescent SCs (QSCs) activate swiftly remain elusive. Here, using a w
Publikováno v:
British Journal of Cancer
Background: microRNAs (miRNAs) have regulatory roles in various cellular processes, including apoptosis. Recently, X-linked inhibitor of apoptosis protein (XIAP) has been reported to be dysregulated in epithelial ovarian cancer (EOC). However, the me
Autor:
Wei Chen, Xiaodi Li, Mengdie Zhang, Longshu Zhou, Weiliang Xiong, Yan Huang, Songshan Jiang, Wenshu Zeng
Publikováno v:
Pharmacogenomics. 17:187-197
Aims: XIAP is upregulated in chemoresistant epithelial ovarian cancer (EOC). However, the molecular mechanism of this dysregulation remains unclear. Materials & methods: The regulation of XIAP by miR-509-3p was investigated by luciferase reporter ass