Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Wenshe Ray Liu"'
Publikováno v:
ACS Bio & Med Chem Au, Vol 4, Iss 5, Pp 233-241 (2024)
Externí odkaz:
https://doaj.org/article/76e35e8cc24740eaaadac13615bfb0a3
Autor:
Peng-Hsun Chase Chen, Xuejiao Shirley Guo, Hanyuan Eric Zhang, Gopal K. Dubey, Zhi Zachary Geng, Carol A. Fierke, Shiqing Xu, J. Trae Hampton, Wenshe Ray Liu
Publikováno v:
ACS Central Science, Vol 10, Iss 4, Pp 782-792 (2024)
Externí odkaz:
https://doaj.org/article/d71941143edf450a9bfc51584dc72d67
Autor:
Wenyue Cao, Chia-Chuan Dean Cho, Zhi Zachary Geng, Namir Shaabani, Xinyu R. Ma, Erol C. Vatansever, Yugendar R. Alugubelli, Yuying Ma, Sankar P. Chaki, William H. Ellenburg, Kai S. Yang, Yuchen Qiao, Robert Allen, Benjamin W. Neuman, Henry Ji, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
ACS Central Science, Vol 8, Iss 2, Pp 192-204 (2022)
Externí odkaz:
https://doaj.org/article/f8e6bc3a68de4550a1f279b547e4da04
Autor:
Jeffery M. Tharp, J. Trae Hampton, Catrina A. Reed, Andreas Ehnbom, Peng-Hsun Chase Chen, Jared S. Morse, Yadagirri Kurra, Lisa M. Pérez, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Most epigenetic regulator inhibitors target tunnels of active sites, rather than the peptide binding groove, leading to concerns with low selectivity. Here the authors use an amber obligate phage library to rapidly identify isoform-selective inhibito
Externí odkaz:
https://doaj.org/article/b1aac1c05c7c4fed851748bbcd7bc307
Autor:
Shuhua G. Li, Kai S. Yang, Lauren R. Blankenship, Chia-Chuan D. Cho, Shiqing Xu, Hongbin Wang, Wenshe Ray Liu
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The emergence and rapid spread of SARS-CoV-2, the pathogen of COVID-19, have caused a worldwide public health crisis. The SARS-CoV-2 main protease (Mpro) is an essential enzyme for the virus and therefore an appealing target for the development of an
Externí odkaz:
https://doaj.org/article/0f590b767e6d480e9aabae8df5814fed
Publikováno v:
Molecules, Vol 26, Iss 9, p 2619 (2021)
Dehydroalanine exists natively in certain proteins and can also be chemically made from the protein cysteine. As a strong Michael acceptor, dehydroalanine in proteins has been explored to undergo reactions with different thiolate reagents for making
Externí odkaz:
https://doaj.org/article/b69d678259144164b3e6ea0f15cb9e09
Autor:
Kai S. Yang, Lauren R. Blankenship, Syuan-Ting Alex Kuo, Yan J. Sheng, Pingwei Li, Carol A. Fierke, David H. Russell, Xin Yan, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
ACS Chemical Biology. 18:449-455
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a491594b34359dab82f6a38e3cff64b
https://doi.org/10.1021/acschembio.2c00695
https://doi.org/10.1021/acschembio.2c00695
Autor:
Lei Zhang, Greg Martin, Kumaravel Mohankumar, Joshua Trae Hampton, Wenshe Ray Liu, Stephen Safe
Publikováno v:
Molecular Pharmacology. 102:80-91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e28d563466ab97446b660499408c434
https://doi.org/10.1124/molpharm.121.000481
https://doi.org/10.1124/molpharm.121.000481
Autor:
Kaustav Khatua, Yugendar R. Alugubelli, Kai S. Yang, Veerabhadra R. Vulupala, Lauren R. Blankenship, Demonta D. Coleman, Sandeep Atla, Sankar P. Chaki, Zhi Zachary Geng, Xinyu R. Ma, Jing Xiao, Peng-Hsun Chase Chen, Chia-Chuan Dean Cho, Erol C. Vatansever, Yuying Ma, Ge Yu, Benjamin W. Neuman, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
bioRxiv
Main protease (MPro) of SARS-CoV-2, the viral pathogen of COVID-19, is a crucial nonstructural protein that plays a vital role in the replication and pathogenesis of the virus. Its protease function relies on three active site pockets to recognize P1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216a999fb1a67e7463a682d08f991ad5
https://doi.org/10.1101/2023.04.11.536467
https://doi.org/10.1101/2023.04.11.536467
Autor:
Zhi Zachary Geng, Sandeep Atla, Namir Shaabani, Veerabhadra R. Vulupala, Kai S. Yang, Yugendar R. Alugubelli, Kaustav Khatua, Peng-Hsun Chase Chen, Jing Xiao, Lauren R. Blankenship, Xinyu R. Ma, Erol C. Vatansever, Chia-Chuan Cho, Yuying Ma, Robert Allen, Henry Ji, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
bioRxiv
SARS-CoV-2 is the coronavirus pathogen of the currently prevailing COVID-19 pandemic. It relies on its main protease (MPro) for replication and pathogenesis. MProis a demonstrated target for the development of antivirals for SARS-CoV-2. Past studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac78ca035630d56fd9f723ac192834af
https://europepmc.org/articles/PMC9882326/
https://europepmc.org/articles/PMC9882326/