Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Wenshe R. Liu"'
Autor:
Brianna J. Klein, Jordan T. Feigerle, Jibo Zhang, Christopher C. Ebmeier, Lixin Fan, Rohit K. Singh, Wesley W. Wang, Lauren R. Schmitt, Thomas Lee, Kirk C. Hansen, Wenshe R. Liu, Yun-Xing Wang, Brian D. Strahl, P. Anthony Weil, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Here the authors report that the Taf2 and Taf14 subunits of the yeast TFIID complex interact and mediate binding to chromatin. Binding of Taf2 to Taf14 promotes a conformational rearrangement in Taf14, resulting in a release of the linker region for
Externí odkaz:
https://doaj.org/article/effb294868064bf0976b394ca5ad6eec
Autor:
Brianna J. Klein, Suk Min Jang, Catherine Lachance, Wenyi Mi, Jie Lyu, Shun Sakuraba, Krzysztof Krajewski, Wesley W. Wang, Simone Sidoli, Jiuyang Liu, Yi Zhang, Xiaolu Wang, Becka M. Warfield, Andrew J. Kueh, Anne K. Voss, Tim Thomas, Benjamin A. Garcia, Wenshe R. Liu, Brian D. Strahl, Hidetoshi Kono, Wei Li, Xiaobing Shi, Jacques Côté, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Acetylation of histone H3K23 has emerged as an essential posttranslational modification, yet this epigenetic mark remains poorly understood. Here, the authors identify the native MORF complex as a histone H3K23-specific acetyltransferase and show tha
Externí odkaz:
https://doaj.org/article/78758c527c604e018605e9ed73ff1cd5
Autor:
Yang Wang, Huan Xie, Yugendar R. Alugubelli, Yuying Ma, Shiqing Xu, Jing Ma, Wenshe R. Liu, Dong Liang
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 676 (2022)
MPI8, a peptidyl aldehyde, is a potent antiviral agent against coronavirus. Due to unique tri-peptide bonds and the formyl functional group, the bioassay of MPI8 in plasma was challenged by a strong interference from water MPI8. Using QTOF LC-MS/MS,
Externí odkaz:
https://doaj.org/article/9cafdd3cf5144515b12e0359ebad12f7
Autor:
Brianna J. Klein, Kendra R. Vann, Forest H. Andrews, Wesley W. Wang, Jibo Zhang, Yi Zhang, Anastasia A. Beloglazkina, Wenyi Mi, Yuanyuan Li, Haitao Li, Xiaobing Shi, Andrei G. Kutateladze, Brian D. Strahl, Wenshe R. Liu, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
YEATS domains are histone acylation readers that recognize crotonyllysine and acetyllysine. Here the authors provide structural insights into how YEATS domains recognize acetyllysines and further show that the human AF9 YEATS domain also binds DNA.
Externí odkaz:
https://doaj.org/article/0a782d5b6bf841aea5a1f2ccefd9b04c
Autor:
Carol F Fierke, Marcetta Y. Darensbourg, Hanyuan Zhang, Christopher R DeLaney, Nattamai Bhuvanesh, Wenshe R Liu, Isaiah Salas, Yan Sheng, Erol Vantansever, D Chase Pectol
Publikováno v:
Dalton Transactions. 50:12226-12233
Numerous organic molecules are known to inhibit the main protease of SARS-CoV-2, (SC2Mpro), a key component in viral replication of the 2019 novel coronavirus. We explore the hypothesis that zinc ions, long used as a medicinal supplement and known to
Autor:
Baoyu Zhao, Tao Jing, A. Phillip West, Pengbiao Xu, Omkar Shinde, Pingwei Li, Chesley Marie Rowlett, Wenshe R. Liu, Yuanjiu Lei
Publikováno v:
Nature
Nucleic acids derived from pathogens induce potent innate immune responses1–6. Cyclic GMP–AMP synthase (cGAS) is a double-stranded DNA sensor that catalyses the synthesis of the cyclic dinucleotide cyclic GMP–AMP, which mediates the induction o
Autor:
Ge Yu, Wesley W. Wang, Kaci C. Kratch, Yuchen Qiao, Shiqing Xu, Jared S. Morse, Sunshine Z. Leeuwon, Xiaoyan Aria Wang, Wenshe R. Liu
Publikováno v:
J Am Chem Soc
Proteins with a functionalized C-terminus such as a C-terminal thioester are key to the synthesis of larger proteins via expressed protein ligation. They are usually made by recombinant fusion to intein. Although powerful, the intein fusion approach
Publikováno v:
ChemBioChem
ChemRxiv
Chembiochem
ChemRxiv
Chembiochem
With the current trajectory of the 2019‐nCoV outbreak unknown, public health and medicinal measures will both be needed to contain spreading of the virus and to optimize patient outcomes. Although little is known about the virus, an examination of
Autor:
Tim Thomas, Hidetoshi Kono, Becka M. Warfield, Jacques Côté, Catherine Lachance, Wei Li, Tatiana G. Kutateladze, Yi Zhang, Brianna J. Klein, Brian D. Strahl, Xiaolu Wang, Wesley W. Wang, Wenshe R. Liu, Wenyi Mi, Benjamin A. Garcia, Andrew J. Kueh, Shun Sakuraba, Jie Lyu, Suk Min Jang, Anne K. Voss, Xiaobing Shi, Simone Sidoli, Jiuyang Liu, Krzysztof Krajewski
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Acetylation of histone H3K23 has emerged as an essential posttranslational modification associated with cancer and learning and memory impairment, yet our understanding of this epigenetic mark remains insufficient. Here, we identify the native MORF c
Autor:
J. Trae Hampton, Duen Shian Wang, Jin Liu, Wenshe R. Liu, Sukant K. Das, Jeffery M. Tharp, Xiaoshan Shayna Wang, Catrina A. Reed, Peng Hsun Chase Chen, Yang Shen, Hamed S. Hayatshahi
Publikováno v:
Angew Chem Int Ed Engl
Superior to linear peptides in biological activities, cyclic peptides are considered to have great potentials used as therapeutic agents. In order to identify cyclic peptide ligands for therapeutic targets, selection from phage-displayed peptide libr