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Akademický článek

Alteration of chromosome structure impacts gene expressions implicated in pancreatic ductal adenocarcinoma cells

Autor: Wenrui Han, Detong Shi, Qiu Yang, Xinxin Li, Jian Zhang, Cheng Peng, Fang Yan

Publikováno v: BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with a five-year survival rate of approximately 10%. Genetic mutations are pivotal drivers in PDAC pathogenesis, but recent investigations also revealed the involvemen

Externí odkaz: https://doaj.org/article/927acce8ec20446b995637bd64f2a524

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Akademický článek

Stevioside reduces inflammation in periodontitis by changing the oral bacterial composition and inhibiting P. gingivalis in mice

Autor: Wenrui Han, Yao Jiao, Sicong Mi, Shu Han, Junji Xu, Song Li, Yi Liu, Lijia Guo

Publikováno v: BMC Oral Health, Vol 23, Iss 1, Pp 1-14 (2023)

Abstract Background Excessive sugar intake has become a major challenge in modern societies. Stevioside is a promising non-calorie sweetener with anti-inflammatory effects; however, its effects on the oral environment and periodontitis remain unclear

Externí odkaz: https://doaj.org/article/500be8639a04452cbf4d61dd2139053f

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Akademický článek

Inhibition of CCR2 attenuates neuroinflammation and neuronal apoptosis after subarachnoid hemorrhage through the PI3K/Akt pathway

Autor: Qi Tian, Yujia Guo, Shi Feng, Chengli Liu, Peibang He, Jianfeng Wang, Wenrui Han, Chen Yang, Zhan Zhang, Mingchang Li

Publikováno v: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-16 (2022)

Abstract Background Neuroinflammation and neuronal apoptosis are closely associated with a poor prognosis in patients with subarachnoid hemorrhage (SAH). We investigated the role of C–C motif chemokine receptor 2 (CCR2) in SAH. Methods Pre-processe

Externí odkaz: https://doaj.org/article/7985d42715724329b202fa0cd4b4bc52

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Akademický článek

Efficient Reprogramming of Mouse Embryonic Stem Cells into Trophoblast Stem-like Cells via Lats Kinase Inhibition

Autor: Yake Gao, Wenrui Han, Rui Dong, Shu Wei, Lu Chen, Zhaolei Gu, Yiming Liu, Wei Guo, Fang Yan

Publikováno v: Biology, Vol 13, Iss 2, p 71 (2024)

Mouse zygotes undergo multiple rounds of cell division, resulting in the formation of preimplantation blastocysts comprising three lineages: trophectoderm (TE), epiblast (EPI), and primitive endoderm (PrE). Cell fate determination plays a crucial rol

Externí odkaz: https://doaj.org/article/f917c7d2859c440781e79dd7e0428946

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Akademický článek

A web-based dynamic nomogram for rupture risk of posterior communicating artery aneurysms utilizing clinical, morphological, and hemodynamic characteristics

Autor: Heng Wei, Wenrui Han, Qi Tian, Kun Yao, Peibang He, Jianfeng Wang, Yujia Guo, Qianxue Chen, Mingchang Li

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

BackgroundPredicting rupture risk is important for aneurysm management. This research aimed to develop and validate a nomogram model to forecast the rupture risk of posterior communicating artery (PcomA) aneurysms.MethodsClinical, morphological, and

Externí odkaz: https://doaj.org/article/6abc6ef6ef934553ae4992d1ecf14c6f

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Akademický článek

Different Hemodynamic Characteristics and Resulting in Different Risks of Rupture Between Wide-Neck and Narrow-Neck Aneurysms

Autor: Heng Wei, Qi Tian, Kun Yao, Jianfeng Wang, Peibang He, Yujia Guo, Wenrui Han, Wenhong Gao, Mingchang Li

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

ObjectiveThis study aimed to determine the ruptured rate and hemodynamic difference between wide-neck aneurysms (WNAs) and narrow-neck aneurysms (NNAs), as well as the hemodynamic parameters of risk factors for aneurysm rupture.MethodsA total of 121

Externí odkaz: https://doaj.org/article/ca10153c176745cea6fc1d4e797e67b0

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Akademický článek

Ferroptosis: a potential therapeutic target for stroke.

Autor: Chengli Liu, Guijun Wang, Wenrui Han, Qi Tian, Mingchang Li

Publikováno v: Neural Regeneration Research; May2024, Vol. 19 Issue 5, p988-997, 10p

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