Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Wenqun Zhong"'
Autor:
Zebin Xiao, Leslie Todd, Li Huang, Estela Noguera-Ortega, Zhen Lu, Lili Huang, Meghan Kopp, Yue Li, Nimisha Pattada, Wenqun Zhong, Wei Guo, John Scholler, Maria Liousia, Charles-Antoine Assenmacher, Carl H. June, Steven M. Albelda, Ellen Puré
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract The desmoplastic stroma in solid tumors presents a formidable challenge to immunotherapies that rely on endogenous or adoptively transferred T cells, however, the mechanisms are poorly understood. To define mechanisms involved, here we treat
Externí odkaz:
https://doaj.org/article/8293ae22274440439fe76629503609b5
Autor:
Kamila Butowska, Xuexiang Han, Ningqiang Gong, Rakan El-Mayta, Rebecca M. Haley, Lulu Xue, Wenqun Zhong, Wei Guo, Karin Wang, Michael J. Mitchell
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 4, Pp 1429-1437 (2023)
Evasion of apoptosis is a hallmark of cancer, attributed in part to overexpression of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2). In a variety of cancer types, including lymphoma, Bcl-2 is overexpressed. Therapeutic targeting of Bcl-2 has d
Externí odkaz:
https://doaj.org/article/ed334e7eb9604a24bf63a6a47cd80494
Autor:
Wei Zhang, Jiegang Yang, Beike Wang, Youtao Lu, Jingbo Yang, Wenqun Zhong, Ziyan Yu, Zhiyuan Qin, Bolin Xiao, Kuiming Wang, Yi Y. Ma, Ravi Amaravadi, Meenhard Herlyn, Junhyong Kim, Xiaowei Xu, Wei Guo
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113352- (2023)
Summary: By sorting receptor tyrosine kinases into endolysosomes, the endosomal sorting complexes required for transport (ESCRTs) are thought to attenuate oncogenic signaling in tumor cells. Paradoxically, ESCRT members are upregulated in tumors. Her
Externí odkaz:
https://doaj.org/article/9ebb2925074d4fe69ec30225145dad72
Autor:
Hezhe Lu, Shujing Liu, Gao Zhang, Lawrence N. Kwong, Yueyao Zhu, John P. Miller, Yi Hu, Wenqun Zhong, Jingwen Zeng, Lawrence Wu, Clemens Krepler, Katrin Sproesser, Min Xiao, Wei Xu, Giorgos C. Karakousis, Lynn M. Schuchter, Jeffery Field, Paul J. Zhang, Meenhard Herlyn, Xiaowei Xu, Wei Guo
Publikováno v:
Cell Reports, Vol 15, Iss 9, Pp 2012-2024 (2016)
Melanoma patients with oncogenic BRAFV600E mutation have poor prognoses. While the role of BRAFV600E in tumorigenesis is well established, its involvement in metastasis that is clinically observed in melanoma patients remains a topic of debate. Here,
Externí odkaz:
https://doaj.org/article/65e3fc8a2453422bbc3fd05a88539a7b
Autor:
Tianshuang Zhu, Rong Wang, Hao Jiang, Alex Shi, Maosheng Chai, Congfa Huang, Shaodong Yang, Wenqun Zhong, Yu Cai
Publikováno v:
The American Journal of Pathology. 193:286-295
Local aggressive growth of odontogenic keratocysts (OKCs) can cause serious bone destruction, even resulting in pathologic fractures of the mandible. With the aim to explore the mechanism of osteoclastogenesis in OKCs, the role of programmed cell dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a03f3b1e742307e93251f33b75eeff6
https://doi.org/10.1016/j.ajpath.2022.11.009
https://doi.org/10.1016/j.ajpath.2022.11.009
Autor:
Wenqun Zhong, Zebin Xiao, Zhiyuan Qin, Jingbo Yang, Yi Wen, Ziyan Yu, Yumei Li, Neil C. Sheppard, Serge Y. Fuchs, Xiaowei Xu, Meenhard Herlyn, Carl H. June, Ellen Pure, Wei Guo
Publikováno v:
Cancer Research.
Chimeric antigen receptor (CAR) T cell therapy has shown remarkable success in the treatment of hematologic malignancies. Unfortunately, it has limited efficacy against solid tumors, even when the targeted antigens are well expressed. A better unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfd0464e043d9fcda8ea7d3c4278a899
https://doi.org/10.1158/0008-5472.can-22-2220
https://doi.org/10.1158/0008-5472.can-22-2220
Autor:
Xuecong Li, Hao Jiang, Maosheng Chai, Tianshuang Zhu, Jingjing Liu, Congfa Huang, Shaodong Yang, Dongsheng Mou, Xiaoshun Zhou, Wenqun Zhong, Yu Cai
Lymphatic malformations(LMs) are a kind of developmental disease most occurring in the head and neck with different symptoms. Clinical experiences showed that the lesion will grow rapidly after infection. Previous studies have shown that inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41986a88ef0fc0cb8b7a99a5e7840efd
https://doi.org/10.21203/rs.3.rs-2714773/v1
https://doi.org/10.21203/rs.3.rs-2714773/v1
Autor:
Liang Wang, Wei Chen, Hongyun Li, Chaohui Xiong, Feng Sun, Xiaoqing Liu, Yuru Hu, Wenxu Wang, Wenqun Zhong, Zheng Liu
Publikováno v:
Analytical Chemistry. 94:4570-4575
Mechanical forces have profound effects on the morphology and migration of cells in a two-dimensional environment. However, cells in vivo mostly migrate in three-dimensional space while physically constrained, and the mechanism by which cellular dyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facbc4f019f6d595f6d2f5b1a225aa61
https://doi.org/10.1021/acs.analchem.1c04962
https://doi.org/10.1021/acs.analchem.1c04962
Autor:
Wenqun Zhong, Wei Guo
Publikováno v:
Blood Cancer Discov
Small extracellular vesicle (sEV, or exosome) communication among cells in the tumor microenvironment has been modeled mainly in cell culture, whereas their relevance in cancer pathogenesis and progression in vivo is less characterized. Here we inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107ffca9015180dc45fe459f4f580c2b
https://europepmc.org/articles/PMC9816814/
https://europepmc.org/articles/PMC9816814/
Publikováno v:
The American Journal of Pathology. 191:857-871
To investigate the role of glycolysis and the M2 isoform of pyruvate kinase (PKM2) in odontogenic keratocysts (OKCs), the glycolytic flux of primary odontogenic keratocyst fibroblasts (OKC-Fs) and normal oral mucosa fibroblasts (OM-Fs) was determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3bcf96f4991ee7fbe00043a30a1f6a8
https://doi.org/10.1016/j.ajpath.2021.02.010
https://doi.org/10.1016/j.ajpath.2021.02.010