Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Wenqin Ying"'
Autor:
Guoling Li, Ming Jin, Zhifang Li, Qingquan Xiao, Jiajia Lin, Dong Yang, Yuanhua Liu, Xing Wang, Long Xie, Wenqin Ying, Haoqiang Wang, Erwei Zuo, Linyu Shi, Ning Wang, Wanjin Chen, Chunlong Xu, Hui Yang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Approximately 10% of monogenic diseases are caused by nonsense point mutations that generate premature termination codons (PTCs), resulting in a truncated protein and nonsense-mediated decay of the mutant mRNAs. Here, we demonstrate a mini-dCas13X–
Externí odkaz:
https://doaj.org/article/c1d13a3e0c5f4ea49953fd17ab93b01c
Autor:
Tanglong Yuan, Nana Yan, Tianyi Fei, Jitan Zheng, Juan Meng, Nana Li, Jing Liu, Haihang Zhang, Long Xie, Wenqin Ying, Di Li, Lei Shi, Yongsen Sun, Yongyao Li, Yixue Li, Yidi Sun, Erwei Zuo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
C->G transversions can be highly desirable editing outcomes. Here the authors optimise CGBEs and provide a deep learning model for predicting editing outcomes based on sequence context.
Externí odkaz:
https://doaj.org/article/84852509bdb0448faac72ae929a50ecc
Autor:
Meiling Zhang, Changyang Zhou, Yu Wei, Chunlong Xu, Hong Pan, Wenqin Ying, Yidi Sun, Yun Sun, Qingquan Xiao, Ning Yao, Wanxia Zhong, Yun Li, Keliang Wu, Gao Yuan, Shoukhrat Mitalipov, Zi-jiang Chen, Hui Yang
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-7 (2019)
Abstract Base editing installs a precise nucleotide change in specific gene loci without causing a double-strand break. Its efficiency in human embryos is generally low, limiting its utility in functional genetic studies. Here, we report that injecti
Externí odkaz:
https://doaj.org/article/b1bfefa0d0c747ad9579025d8f7239ef
Autor:
Erwei Zuo, Xiaona Huo, Xuan Yao, Xinde Hu, Yidi Sun, Jianhang Yin, Bingbing He, Xing Wang, Linyu Shi, Jie Ping, Yu Wei, Wenqin Ying, Wei Wei, Wenjia Liu, Cheng Tang, Yixue Li, Jiazhi Hu, Hui Yang
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-18 (2017)
Abstract Background The CRISPR/Cas9 system has become an efficient gene editing method for generating cells carrying precise gene mutations, including the rearrangement and deletion of chromosomal segments. However, whether an entire chromosome could
Externí odkaz:
https://doaj.org/article/ba642f6707df4d1eba98706420199b3a
Autor:
Guang Yang, Changyang Zhou, Ran Wang, Shisheng Huang, Yu Wei, Xianfa Yang, Yajing Liu, Jianan Li, Zongyang Lu, Wenqin Ying, Xiajun Li, Naihe Jing, Xingxu Huang, Hui Yang, Yunbo Qiao
Publikováno v:
Cell Reports, Vol 26, Iss 2, Pp 302-312.e4 (2019)
Summary: The coactivator-associated arginine methyltransferase CARM1 catalyzes the methylation of histone H3 arginine 17/26 (H3R17/26me) and non-histone proteins at arginine residues to regulate gene transactivation through profiling or Carm1 overexp
Externí odkaz:
https://doaj.org/article/9cf307be5e314d41ba443d6e04adb33c
Autor:
Jia Huang, Bingbing He, Xiali Yang, Xin Long, Yinghui Wei, Yanxia Gao, Yuan Fang, Wenqin Ying, Zikang Wang, Chao Li, Yingsi Zhou, Shuaishuai Li, Linyu Shi, Fan Guo, Haibo Zhou, Hui Yang, Jun Wu
SUMMARYInterspecies organogenesis via blastocyst complementation provides a unique platform to study development in an evolutionarily context and holds potential to overcome world-wide organ shortages1. By using this technique, rat pancreas, thymus,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cad6b4ad4f6db523027ccb421609c81
https://doi.org/10.1101/2023.04.13.536774
https://doi.org/10.1101/2023.04.13.536774
Autor:
Long Xie, Wenqin Ying, Yixue Li, Erwei Zuo, Nana Yan, Di Li, Lei Shi, Nana Li, Tianyi Fei, Jitan Zheng, Yongyao Li, Yongsen Sun, Tanglong Yuan, Haihang Zhang, Yidi Sun, Jing Liu, Juan Meng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Efficient and precise base editors (BEs) for C-to-G transversion are highly desirable. However, the sequence context affecting editing outcome largely remains unclear. Here we report engineered C-to-G BEs of high efficiency and fidelity, with the seq
Autor:
Yu Wei, Changyang Zhou, Wenqin Ying, Haibo Zhou, Yajing Liu, Ruiming Lv, Erwei Zuo, Qimeng Zhao, Yingsi Zhou, Yidi Sun, Hui Yang
Publikováno v:
Protein & Cell
Autor:
Wu Wei, Yixue Li, Liyun Yuan, Lars M. Steinmetz, Tanglong Yuan, Wenqin Ying, Yidi Sun, Hui Yang, Hao Sun, Erwei Zuo
Publikováno v:
Nat Protoc
Genome editing holds great potential for correcting pathogenic mutations. We developed a method called GOTI (genome-wide off-target analysis by two-cell embryo injection) to detect off-target mutations by editing one blastomere of two-cell mouse embr
Autor:
Wu Wei, Erwei Zuo, Rong Zeng, Changyang Zhou, Yixue Li, Jing Liu, Tanglong Yuan, Yidi Sun, Hui Yang, Bingbing He, Wenqin Ying
Publikováno v:
Nature Methods. 17:600-604
Cytosine base editors (CBEs) offer a powerful tool for correcting point mutations, yet their DNA and RNA off-target activities have caused concerns in biomedical applications. We describe screens of 23 rationally engineered CBE variants, which reveal