Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Wenping Lyu"'
1
Akademický článek
Structure of G protein-coupled receptor GPR1 bound to full-length chemerin adipokine reveals a chemokine-like reverse binding mode.
Autor: Aijun Liu, Yezhou Liu, Geng Chen, Wenping Lyu, Fang Ye, Junlin Wang, Qiwen Liao, Lizhe Zhu, Yang Du, Richard D Ye
Publikováno v: PLoS Biology, Vol 22, Iss 10, p e3002838 (2024)
Chemerin is an adipokine with chemotactic activity to a subset of leukocytes. Chemerin binds to 3 G protein-coupled receptors, including chemokine-like receptor 1 (CMKLR1), G protein-coupled receptor 1 (GPR1), and C-C chemokine receptor-like 2 (CCRL2
Externí odkaz: https://doaj.org/article/7ff033937a9143a7a23d76e053593b98
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2
Akademický článek
Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns
Autor: Geng Chen, Xiankun Wang, Qiwen Liao, Yunjun Ge, Haizhan Jiao, Qiang Chen, Yezhou Liu, Wenping Lyu, Lizhe Zhu, Gydo C. P. van Zundert, Michael J. Robertson, Georgios Skiniotis, Yang Du, Hongli Hu, Richard D. Ye
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Detection of invading bacteria is key to immunity. Here, the authors report cryo-electron microscopy structures of agonist-bound formyl peptide receptor 1 (FPR1), that reveal structural basis for recognition of bacteria-derived formyl peptides.
Externí odkaz: https://doaj.org/article/213ab71046034930b5702d46eba98f44
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3
Akademický článek
Enhanced-Sampling Simulations for the Estimation of Ligand Binding Kinetics: Current Status and Perspective
Autor: Katya Ahmad, Andrea Rizzi, Riccardo Capelli, Davide Mandelli, Wenping Lyu, Paolo Carloni
Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)
The dissociation rate (koff) associated with ligand unbinding events from proteins is a parameter of fundamental importance in drug design. Here we review recent major advancements in molecular simulation methodologies for the prediction of koff. Nex
Externí odkaz: https://doaj.org/article/14bf3dc338c247c8bf5b4ef51f803dc3
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4
Cryo-EM structure of the human chemerin receptor 1–Gi protein complex bound to the C-terminal nonapeptide of chemerin
Autor: Junlin Wang, Geng Chen, Qiwen Liao, Wenping Lyu, Aijun Liu, Lizhe Zhu, Yang Du, Richard D. Ye
Publikováno v: Proceedings of the National Academy of Sciences. 120
Chemerin is a processed protein that acts on G protein-coupled receptors (GPCRs) for its chemotactic and adipokine activities. The biologically active chemerin (chemerin 21-157) results from proteolytic cleavage of prochemerin and uses its C-terminal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::318d964693ef748a7741d177010498a4
https://doi.org/10.1073/pnas.2214324120
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5
Rational evolution of a recombinant DNA polymerase for efficient incorporation of unnatural nucleotides by dual-site boosting
Autor: Wenping Lyu, Ruyin Cao, Lili Zhai, Qingqing Xie, Zi Wang, Yue Zheng, Wenwei Zhang, Alexander Buell, Xun Xu, Yuliang Dong, Chongjun Xu
Machine learning-based modelling assisting functional-oriented enzyme engineering is normally built on a predefined sequence space. Efficiently defining the determinant amino acid positions upon which the combinatorial mutational library is construct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c42a31f69879d5998e0a060ceab6d6
https://doi.org/10.21203/rs.3.rs-1570035/v1
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7
Effect of in vivo post-translational modifications of the HMGB1 protein upon binding to platinated DNA: a molecular simulation study
Autor: Wenping Lyu, Lv, Fabio, Arnesano, Paolo, Carloni, Giovanni, Natile, Giulia, Rossetti
Publikováno v: Nucleic acids symposium series 46(22), 11687-11697 (2018). doi:10.1093/nar/gky1082
Nucleic Acids Research
Cisplatin is one of the most widely used anticancer drugs. Its efficiency is unfortunately severely hampered by resistance. The High Mobility Group Box (HMGB) proteins may sensitize tumor cells to cisplatin by specifically binding to platinated DNA (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e8dce865071f0c08b348413c0beb6199
https://hdl.handle.net/2128/21826
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9
Akademický článek
Effect of in vivo post-translational modifications of the HMGB1 protein upon binding to platinated DNA: a molecular simulation study.
Autor: Lv WL; Computational Biomedicine, Institute for Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Forschungszentrum Jülich, 52425 Jülich, Germany.; Faculty of Mathematics, Computer Science and Natural Sciences, RWTH-Aachen University, 52056 Aachen, Germany.; Computation-Based Science and Technology Research Center, Cyprus Institute, 2121 Aglantzia, Nicosia, Cyprus., Arnesano F; Department of Chemistry, University of Bari 'A. Moro', via Edoardo Orabona 4, 70125 Bari, Italy., Carloni P; Computational Biomedicine, Institute for Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Forschungszentrum Jülich, 52425 Jülich, Germany., Natile G; Department of Chemistry, University of Bari 'A. Moro', via Edoardo Orabona 4, 70125 Bari, Italy., Rossetti G; Computational Biomedicine, Institute for Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Forschungszentrum Jülich, 52425 Jülich, Germany.; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, 52062 Aachen, Germany.; Jülich Supercomputing Centre (JSC), Forschungszentrum Jülich, 52425 Jülich, Germany.
Publikováno v: Nucleic acids research [Nucleic Acids Res] 2018 Dec 14; Vol. 46 (22), pp. 11687-11697.
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