C-terminal extensions of Ku70 and Ku80 differentially influence DNA end binding properties

Autor: Inagawa, T., Wennink, T., Lebbink, J.H.G., Keijzers, G., Florea, B.I., Verkaik, N.S., Gent, D.C. van

The Ku70/80 heterodimer binds to DNA ends and attracts other proteins involved in the non-homologous end-joining (NHEJ) pathway of DNA double-strand break repair. We developed a novel assay to measure DNA binding and release kinetics using difference

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______202::2024749ff7e91586d3509fb2f6f0ff1e
https://hdl.handle.net/1887/139160

C-Terminal Extensions of Ku70 and Ku80 Differentially Influence DNA End Binding Properties.

Autor: Inagawa T; Department of Molecular Genetics, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands., Wennink T; Department of Molecular Genetics, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands., Lebbink JHG; Department of Molecular Genetics, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands.; Department of Radiation Oncology, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands., Keijzers G; Department of Molecular Genetics, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands., Florea BI; Department of Molecular Genetics, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands., Verkaik NS; Department of Molecular Genetics, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands., van Gent DC; Department of Molecular Genetics, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2020 Sep 14; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 14.