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pro vyhledávání: '"Wennie Chen"'
Autor:
Kristin M. Zimmerman Savill, Brian B. Lee, Jason Oeh, Jie Lin, Eva Lin, Wei-Jen Chung, Amy Young, Wennie Chen, Monika Miś, Kathryn Mesh, Jeffrey Eastham, Florian Gnad, Zhaoshi Jiang, Eric W. Stawiski, Benjamin Haley, Anneleen Daemen, Xiaojing Wang, Hartmut Koeppen, Zora Modrusan, Scott E. Martin, Deepak Sampath, Kui Lin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
How resistance to different classes of AKT inhibitors can emerge is unclear. Here, the authors show that resistance to allosteric inhibitors is mainly due to mutation of AKT1 while the ATP competitive resistance is driven by activation of PIM kinases
Externí odkaz:
https://doaj.org/article/942eedd4f9f14214ba862fbc21b1991f
