Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Wenling E, Chang"'
Autor:
Henry S Gibbons, Stacey M Broomall, Lauren A McNew, Hajnalka Daligault, Carol Chapman, David Bruce, Mark Karavis, Michael Krepps, Paul A McGregor, Charles Hong, Kyong H Park, Arya Akmal, Andrew Feldman, Jeffrey S Lin, Wenling E Chang, Brandon W Higgs, Plamen Demirev, John Lindquist, Alvin Liem, Ed Fochler, Timothy D Read, Roxanne Tapia, Shannon Johnson, Kimberly A Bishop-Lilly, Chris Detter, Cliff Han, Shanmuga Sozhamannan, C Nicole Rosenzweig, Evan W Skowronski
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17836 (2011)
BackgroundDespite the decades-long use of Bacillus atrophaeus var. globigii (BG) as a simulant for biological warfare (BW) agents, knowledge of its genome composition is limited. Furthermore, the ability to differentiate signatures of deliberate adap
Externí odkaz:
https://doaj.org/article/7456dc990b564d8c95e462b76cd16899
Autor:
Matthew W Peterson, Steven Z Fairchild, Tamara C Otto, Mojdeh Mohtashemi, Douglas M Cerasoli, Wenling E Chang
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20335 (2011)
Human Serum paraoxonase 1 (HuPON1) is an enzyme that has been shown to hydrolyze a variety of chemicals including the nerve agent VX. While wildtype HuPON1 does not exhibit sufficient activity against VX to be used as an in vivo countermeasure, it ha
Externí odkaz:
https://doaj.org/article/1d58d3316629452080c13c1295c48823
Publikováno v:
BMC Bioinformatics
Background Pathogen metadata includes information about where and when a pathogen was collected and the type of environment it came from. Along with genomic nucleotide sequence data, this metadata is growing rapidly and becoming a valuable resource n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4b69c998167ef19865b3f1075b088d
http://europepmc.org/articles/PMC5025631
http://europepmc.org/articles/PMC5025631
Publikováno v:
Biophysical Journal. 100(8):2024-2032
Experimental and epidemiological studies have shown that the nonsteroidal antiinflammatory drug naproxen may be useful in the treatment of Alzheimer's disease. To investigate the interactions of naproxen with Aβ dimers, which are the smallest cytoto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315b3e19ad28f642f7751eeb66fb7bca
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 78:2849-2860
Non-steroidal anti-inflammatory drugs are considered as potential therapeutic agents against Alzheimer’s disease. Using REMD and atomistic implicit solvent model we studied the mechanisms of binding of naproxen and ibuprofen to the Aβ fibril deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfdb12c14b05adceff6b4940d715464c
https://doi.org/10.1002/prot.22804
https://doi.org/10.1002/prot.22804
Autor:
George A. Saviolakis, Jose M. Pizarro, Mustansir Y. Dawood, Mark A. Smith, Lucille A. Lumley, Wenling E. Chang, Jinesh D. Shah, Christopher L. Robison, Nadia Kendall, Brian Mark, James L. Meyerhoff, Arun Alagappan, Mariama J. Bah, Wilma Medina
Publikováno v:
Brain Research. 1025:10-20
Acute social defeat in mice activates the hypothalamic-pituitary-adrenal axis (HPA) and induces long-term behavioral changes, including exaggerated fear responses and inhibition of territorial behavior. Stress-induced hormonal and neurotransmitter re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d021974fcf730f898cbbe61df03c33
https://doi.org/10.1016/j.brainres.2004.06.085
https://doi.org/10.1016/j.brainres.2004.06.085
Autor:
George A. Saviolakis, Jose M. Pizarro, Lucille A. Lumley, Jinesh D. Shah, Eric G. Midboe, Wenling E. Chang, Linnzi K.M. Wright, Arun Alagappan, Christopher L. Robison, James L. Meyerhoff, Mariama J. Bah, Douglas M. Cerasoli
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 126(2)
The highly toxic organophosphorus compound VX [O-ethyl S-[2-(diisopropylamino)ethyl]methylphosphonate] is an irreversible inhibitor of the enzyme acetylcholinesterase (AChE). Prolonged inhibition of AChE increases endogenous levels of acetylcholine a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8416967b23236ecd2e8dfee71f11a4e
https://pubmed.ncbi.nlm.nih.gov/22240983
https://pubmed.ncbi.nlm.nih.gov/22240983
Autor:
Wenling E. Chang, Mojdeh Mohtashemi, Tamara C. Otto, Matthew W. Peterson, Douglas M. Cerasoli, Steven Z. Fairchild
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 5, p e20335 (2011)
PLoS
PLoS ONE, Vol 6, Iss 5, p e20335 (2011)
PLoS
Human Serum paraoxonase 1 (HuPON1) is an enzyme that has been shown to hydrolyze a variety of chemicals including the nerve agent VX. While wildtype HuPON1 does not exhibit sufficient activity against VX to be used as an in vivo countermeasure, it ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037aa750316c543cb8bdecc942328f99
https://pubmed.ncbi.nlm.nih.gov/21655255
https://pubmed.ncbi.nlm.nih.gov/21655255
Publikováno v:
Proteins. 78(13)
Nonsteroidal anti-inflammatory drugs are considered as potential therapeutic agents against Alzheimer's disease. Using replica exchange molecular dynamics and atomistic implicit solvent model, we studied the mechanisms of binding of naproxen and ibup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b4a2b7e479e9cab6ed0b5dcee995e61
https://pubmed.ncbi.nlm.nih.gov/20635343
https://pubmed.ncbi.nlm.nih.gov/20635343
Autor:
Adel Hamza, Wenling E. Chang, Steven Z. Fairchild, Douglas M. Cerasoli, Chang-Guo Zhan, Matthew W. Peterson
Publikováno v:
Journal of molecular modeling. 17(1)
Human serum paraoxonase 1 (HuPON1) is an enzyme that can hydrolyze various chemical warfare nerve agents including VX. A previous study has suggested that increasing HuPON1’s VX hydrolysis activity one to two orders of magnitude would make the enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c829a6cb7325323976fe9e92fa8499ec
https://pubmed.ncbi.nlm.nih.gov/20379755
https://pubmed.ncbi.nlm.nih.gov/20379755