Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Wenlang Liu"'
Autor:
Jiandong Yuan, Wenlang Liu, Xiaohui Jiang, Yangqing Huang, Leilei Zong, Haifeng Ding, Xinyi Shen, Yujia Sun, Xiangyang Feng, Xionghao Li, Yunsong Song, Jianing Gu, Yuhuai Wang, Hao Liu, Zheng Zheng
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The dual activation of glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) has emerged as a promising therapeutic strategy for managing type 2 diabetes and obesity. Tirzepatide, a dual a
Externí odkaz:
https://doaj.org/article/3475865ee217480093abf23428858a6b
Publikováno v:
Journal of Chemical Information and Modeling. 62:3651-3663
Protein kinases intrinsically translate their conformations between active and inactive states, which is key to their enzymatic activities. The conformational flipping of the three-residue conservative motif, Asp-Phe-Gly (DFG), is crucial for many ki
Publikováno v:
Journal of chemical information and modeling. 62(22)
Fast and accurate biomolecular free energy estimation has been a significant interest for decades, and with recent advances in computer hardware, interest in new method development in this field has even grown. Thorough configurational state sampling
The rapid spread of the COVID-19 outbreak is now a global threat with over a million diagnosed cases and more than 70 thousand deaths. Specific treatments and effective drugs regarding such disease are in urgent need. To contribute to the drug discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d09a45731f6defaef7b48c95aa2b970
https://doi.org/10.26434/chemrxiv.12090426.v1
https://doi.org/10.26434/chemrxiv.12090426.v1